Research Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis Stella Talic, Shivangi Shah, Holly Wild, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-068302 (Published 18 November 2021)Cite this as: BMJ 2021;375:e068302 Abstract Objective To review the evidence on the effectiveness of public health...

Top Stories from #ISICEM21 #ISICEM21: Advances in Resistant Gram-Negative Pneumonia In an interesting discussion at the 40th ISICEM International Symposium on Intensive Care & Emergency Medicine,  Richard Wunderink, Professor of Medicine, Pulmonary and Critical Care Division of Northwestern University’s Feinberg School of Medicine and Medical Director, Medical ICU, Northwestern Memorial Hospital, Chicago, discussed rising levels of multi-drug resistance...

ARTICLES|ONLINE FIRST Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published: November 17, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)01825-0 Summary Background Aspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate the efficacy and safety of aspirin in patients admitted ...

Original Investigation November 2, 2021 Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial Julia A. Bielicki, Wolfgang Stöhr, Sam Barratt, et al JAMA. 2021;326(17):1713-1724. doi:10.1001/jama.2021.17843 Abstract Importance  The optimal dose and duration of oral amoxicillin for children with community-acquired pn...

Research Letter November 1, 2021 Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection Diana Zhong, Shaoming Xiao, Amanda K. Debes, et al JAMA. Published online November 1, 2021. doi:10.1001/jama.2021.19996 Waning serum antibodies against SARS-CoV-2 have raised questions about long-term immunity. Lower antibody levels to SARS-CoV-2 spike protein are associated with breakthroug...

Original Investigation October 11, 2021 Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial Jean M. Connors, Maria M. Brooks, Frank C. Sciurba, et al JAMA. 2021;326(17):1703-1712. doi:10.1001/jama.2021.17272 Abstract Importance  Acutely ill inpatients with COVID-19 typically receive antithrombotic therapy, although the risks and benefits of th...

Resuscitative Transesophageal Echocardiography Programme in the ED: 5 Tips for Success Over the past few years, inspired by landmark publications,1,2,3 demonstrating the feasibility, safety and clinical value of transesophageal echocardiography (TEE) performed by emergency physicians (EPs), a number of U.S. hospitals have established TEE programmes based in their emergency departments (EDs). In 2017, the American College of Emergency Physicians (ACEP) published th...

ORIGINAL ARTICLE Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab Anil Gupta, Yaneicy Gonzalez-Rojas, Erick Juarez, et al N Engl J Med October 27, 2021DOI: 10.1056/NEJMoa2107934 Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) disproportionately results in hospitalization or death in older patients and those with underlying conditions. Sotrovimab is a pan-sarbecovirus monoclonal antibody that was designed to preve...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Vasopressor Management in Septic Shock: General Overview and Personalised Approaches This article summarises the proceedings of an ESICM webinar in which two experts discuss vasopressor therapy and its fundamental role in the treatment of septic shock-induced hypotension. They provide an overview of severe septic shock, the benefits of second-line vasopressors and their use in COVID-19 patients....

Original Investigation October 11, 2021 Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial Jean M. Connors, Maria M. Brooks, Frank C. Sciurba, et al JAMA. Published online October 11, 2021. doi:10.1001/jama.2021.17272 Abstract Importance  Acutely ill inpatients with COVID-19 typically receive antithromb...