Research Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study Ariel Israel, Eugene Merzon, Alejandro A Schäffer, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067873 (Published 25 November 2021)Cite this as: BMJ 2021;375:e067873 Abstract Objectives To determine whether time elapsed since the second injection of the Pfizer-BioNTech BNT162b2 mRNA vaccine was significantly associated with the risk of...

Research Christmas 2021: Time Warp Ghost in the machine or monkey with a typewriter—generating titles for Christmas research articles in The BMJ using artificial intelligence: observational study Robin Marlow, Dora Wood BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067732 (Published 15 December 2021)Cite this as: BMJ 2021;375:e067732 Abstract Objective To determine whether artificial intelligence (AI) can generate plausible and eng...

Research Christmas 2021: Get Lucky Giving science the finger—is the second-to-fourth digit ratio (2D:4D) a biomarker of good luck? A cross sectional study James M Smoliga, Lucas K Fogaca, Jessica S Siplon, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067849 (Published 15 December 2021)Cite this as: BMJ 2021;375:e067849 Abstract Objectives To explore whether random chance, weak research methodology, or inappropriate reporting can lead ...

Research Christmas 2021: Trading Places Bah humbug! Association between sending Christmas cards to trial participants and trial retention: randomised study within a trial conducted simultaneously across eight host trials Elizabeth Coleman, Catherine Arundel, Laura Clark, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067742 (Published 14 December 2021)Cite this as: BMJ 2021;375:e067742 Abstract Objectives To determine the effectiveness ...

Original | Open Access | Published: 23 November 2021 Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial G. Bellingan, F. Jacono, J. Bannard-Smith, et al Intensive Care Med Abstract Purpose Bone marrow-derived, allogeneic, multipotent adult progenitor cells demonstrated safety and efficacy in preclinical models of acute re...

ORIGINAL ARTICLE Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults Mark D. Neuman, Rui Feng, Jeffrey L. Carson, et al N Engl J Med 2021; 385:2025-2035DOI: 10.1056/NEJMoa2113514 Abstract BACKGROUND The effects of spinal anesthesia as compared with general anesthesia on the ability to walk in older adults undergoing surgery for hip fracture have not been well studied. METHODS We conducted a pragmatic, randomized superiority tria...

ORIGINAL ARTICLE Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab Anil Gupta, Yaneicy Gonzalez-Rojas, Erick Juarez, et al N Engl J Med 2021; 385:1941-1950DOI: 10.1056/NEJMoa2107934 Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) disproportionately results in hospitalization or death in older patients and those with underlying conditions. Sotrovimab is a pan-sarbecovirus monoclonal antibody that was designed to prevent...

Research Sex differences in mortality among binational cohort of people with chronic kidney disease: population based data linkage study Nicole L De La Mata, Brenda Rosales, Grace MacLeod, et al BMJ 2021; 375 doi: https://doi.org/10.1136/BMJ-2021-068247 (Published 16 November 2021)Cite this as: BMJ 2021;375:e068247 Abstract Objective To evaluate sex differences in mortality among people with kidney failure compared with the general population. Desig...

Original Investigation December 7, 2021 Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial Gustavo A. Ospina-Tascón, Luis Eduardo Calderón-Tapia, Alberto F. García, et al JAMA. 2021;326(21):2161-2171. doi:10.1001/jama.2021.20714 Abstract Importance  The effect of high-flow oxygen therapy vs convention...

Original Investigation December 7, 2021 Effect of a Diagnostic Strategy Using an Elevated and Age-Adjusted D-Dimer Threshold on Thromboembolic Events in Emergency Department Patients With Suspected Pulmonary Embolism: A Randomized Clinical Trial Yonathan Freund, Anthony Chauvin, Sonia Jimenez, et al JAMA. 2021;326(21):2141-2149. doi:10.1001/jama.2021.20750 Abstract Importance  Uncontrolled studies suggest that pulmonary embolism (PE...