ORIGINAL ARTICLEFREE PREVIEW Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults Simon Finfer, Sharon Micallef, Naomi Hammond, et al N Engl J Med January 18, 2022DOI: 10.1056/NEJMoa2114464 Abstract BACKGROUND Whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution (saline) in critically ill patients reduces the risk of acute kidney injury or death is uncertain. METH...

ARTICLES| VOLUME 22, ISSUE 2, P183-195, FEBRUARY 01, 2022 Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study Anika Singanayagam, Seran Hakki, Jake Dunning, et al Lancet Infect Dis 2022; 22: 183-195 Summary Background The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading globally, i...

Research Letter December 3, 2021 Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals Brian Grunau, David M. Goldfarb, Michael Asamoah-Boaheng, et al JAMA. 2022;327(3):279-281. doi:10.1001/jama.2021.21921 Standard dosing intervals for BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines are 21 and 28 days, respectively.1 Data suggest improved effectiveness of ChAdOx1 adenoviral2 and other nonreplicating va...

ORIGINAL ARTICLE Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents Samantha M. Olson, Margaret M. Newhams, Natasha B. Halasa, et al N Engl J Med 2022; 386:713-723DOI: 10.1056/NEJMoa2117995 Abstract BACKGROUND The increasing incidence of pediatric hospitalizations associated with coronavirus disease 2019 (Covid-19) caused by the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United...

Original Investigation November 17, 2021 Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial Kamrouz Ghadimi, Jhaymie Cappiello, Mary Cooter-Wright, et al JAMA Surg. 2022;157(1):e215856. doi:10.1001/jamasurg.2021.5856 Abstract Importance  Inhaled nitric oxide (iNO) is commonly administered for selectively inhaled pulmonary vasodilation and prevention of oxidative injury after lung transplant (LT). Inhal...

Original Investigation January 18, 2022 Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial Jeffrey S. Berger, Lucy Z. Kornblith, Michelle N. Gong, et al JAMA. 2022;327(3):227-236. doi:10.1001/jama.2021.23605 Abstract Importance  Platelets represent a potential therapeutic target for improved clinical...

ARTICLES|ONLINE FIRST Pandemic preparedness and COVID-19: an exploratory analysis of infection and fatality rates, and contextual factors associated with preparedness in 177 countries, from Jan 1, 2020, to Sept 30, 2021 COVID-19 National Preparedness Collaborators Lancet Published:February 01, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00172-6 Summary Background National rates of COVID-19 infection and fatality have varied dramatically since the o...

ARTICLES|ONLINE FIRST Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial ACTIV-3/Therapeutics for Inpatients with COVID-19 (TICO) Study Group Lancet Infect Dis Published:December 23, 2021DOI:https://doi.org/10.1016/S1473-3099(21)00751-9 Summary Background We aimed to assess the efficacy and safety of two neutralising mono...

ARTICLES| VOLUME 399, ISSUE 10325, P665-676, FEBRUARY 12, 2022 Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet 2022; 399: 665-676 Summary Background Casirivimab and imdevimab are non-competing monoclonal antibodies that bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike glycoprotein, ...

ARTICLES|ONLINE FIRST Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis Manoj V Maddali, Matthew Churpek, Tai Pham, et al Lancet Respir Med Published:January 10, 2022DOI:https://doi.org/10.1016/S2213-2600(21)00461-6 Summary Background Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct...