ARTICLES|ONLINE FIRST Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 COVID-19 Excess Mortality Collaborators † Lancet Published:March 10, 2022 DOI:https://doi.org/10.1016/S0140-6736(21)02796-3 Summary Background Mortality statistics are fundamental to public health decision making. Mortality varies by time and location, and its measurement is affected by well known biases that hav...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 1, P97-111, JANUARY 01, 2022 The Usefulness of the Rapid Shallow Breathing Index in Predicting Successful Extubation: A Systematic Review and Meta-analysis Vatsal Trivedi, Dipayan Chaudhuri, Rehman Jinah, et al Chest 2022; 161: 97-111 Background Clinicians use several measures to ascertain whether individual patients will tolerate liberation from mechanical ventilation, including the rapid s...

ORIGINAL ARTICLE Effectiveness of Covid-19 Vaccines over a 9-Month Period in North Carolina Dan-Yu Lin, Yu Gu, Bradford Wheeler, et al N Engl J Med 2022; 386:933-941DOI: 10.1056/NEJMoa2117128 Abstract BACKGROUND The duration of protection afforded by coronavirus disease 2019 (Covid-19) vaccines in the United States is unclear. Whether the increase in postvaccination infections during the summer of 2021 was caused by declining immunity over time, the emer...

ARTICLES| VOLUME 399, ISSUE 10331, P1254-1264, MARCH 26, 2022 Effectiveness of rAd26-rAd5, ChAdOx1 nCoV-19, and BBIBP-CorV vaccines for risk of infection with SARS-CoV-2 and death due to COVID-19 in people older than 60 years in Argentina: a test-negative, case-control, and retrospective longitudinal study Analía Rearte, Juan Manuel Castelli, Ramiro Rearte, et al Lancet 2022; 399: 1254-1264 Summary Background In January, 2021, a vaccinatio...

Original Investigation January 24, 2022 Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial Gavin D. Perkins, Chen Ji, Bronwen A. Connolly, et al JAMA. Published online January 24, 2022. doi:10.1001/jama.2022.0028 Key Points Question  What is the effect of initial noni...

ORIGINAL ARTICLEFREE PREVIEW Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia Kristi L. Watterberg, Michele C. Walsh, Lei Li, et al N Engl J Med 2022; 386:1121-1131DOI: 10.1056/NEJMoa2114897 Abstract BACKGROUND Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment after the second postnatal...

Original Investigation Caring for the Critically Ill PatientJanuary 24, 2022 Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19 Hidde Heesakkers, Johannes G. van der Hoeven, Stijn Corsten, et al JAMA. Published online January 24, 2022. doi:10.1001/jama.2022.0040 Key Points Question  What are the 1-year outcomes among patients who survive intensive care unit (ICU) treatment for ...

ORIGINAL ARTICLE Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar Laith J. Abu-Raddad, Hiam Chemaitelly, Houssein H. Ayoub, et al N Engl J Med March 9, 2022DOI: 10.1056/NEJMoa2200797 Abstract BACKGROUND Waning of vaccine protection against coronavirus disease 2019 (Covid-19) and the emergence of the omicron (or B.1.1.529) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to expedited efforts...

ARTICLES|ONLINE FIRST Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis COVID-19 Forecasting Team Lancet Published: February 24, 2022 DOI:https://doi.org/10.1016/S0140-6736(21)02867-1 Summary Background The infection–fatality ratio (IFR) is a metric that quantifies the likelihood of an individual dying once infected with a pathogen. Understanding the determinants of IFR var...

Original Investigation January 21, 2022 Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants Emma K. Accorsi, Amadea Britton, Katherine E. Fleming-Dutra, et al JAMA. Published online January 21, 2022. doi:10.1001/jama.2022.0470 Key Points Question  What is the association between 3 doses of mRNA COVID-19 vaccine and symptomatic SARS-CoV-2 infection with th...