ORIGINAL ARTICLE Tranexamic Acid in Patients Undergoing Noncardiac Surgery P.J. Devereaux, Maura Marcucci, Thomas W. Painter, et al N Engl J Med April 2, 2022DOI: 10.1056/NEJMoa2201171 Abstract BACKGROUND Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. METHODS We conducted a trial involving patients undergoing noncardiac surgery. Patients...

ORIGINAL ARTICLE Effectiveness of the BNT162b2 Vaccine after Recovery from Covid-19 Ariel Hammerman, Ruslan Sergienko, Michael Friger, et al N Engl J Med 2022; 386:1221-1229DOI: 10.1056/NEJMoa2119497 Abstract BACKGROUND The risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decreases substantially among patients who have recovered from coronavirus disease 2019 (Covid-19). However, it is unknown how long protective immunit...

ARTICLES|ONLINE FIRST Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study Sue Ann Costa Clemens, Lily Weckx, Ralf Clemens, et al Lancet Published:January 21, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00094-0 Summary Introduction The inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac, Sinovac...

ORIGINAL ARTICLE Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection Victoria Hall, Sarah Foulkes, Ferdinando Insalata, et al N Engl J Med 2022; 386:1207-1220DOI: 10.1056/NEJMoa2118691 Abstract BACKGROUND The duration and effectiveness of immunity from infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relevant to pandemic policy interventions, including the timing of vaccin...

ORIGINAL ARTICLE Homologous and Heterologous Covid-19 Booster Vaccinations Robert L. Atmar, Kirsten E. Lyke, Meagan E. Deming, et al N Engl J Med January 26, 2022DOI: 10.1056/NEJMoa2116414 Abstract BACKGROUND Although the three vaccines against coronavirus disease 2019 (Covid-19) that have received emergency use authorization in the United States are highly effective, breakthrough infections are occurring. Data are needed on the serial use of homologous ...

CORRESPONDENCE Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant Emi Takashita, Noriko Kinoshita, Seiya Yamayoshi, et al N Engl J Med January 26, 2022DOI: 10.1056/NEJMc2119407 TO THE EDITOR: In November 2021, the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in South Africa.1 Since then, omicron has rapidly spread around the world. On November 26, 2021, the World Healt...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalSurvival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort studyWhebell S. et al. Natural language processing diagnosed behavioral disturbance vs confusion assessment method for the intensive care unit: prevalence, patient characteristics, overlap, and association with treatment and outcomeYoung M. et al. OPEN ACCESS ~ Systematic ReviewPrediction of good neurologi...

Research Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) Michael Fralick, Michael Colacci, Laveena Munshi, et al BMJ 2022; 376 doi: https://doi.org/10.1136/bmj-2021-068585 (Published 23 March 2022)Cite this as: BMJ 2022;376:e068585 Abstract Objectives To assess the effectiveness of prone positioning to reduce the risk of death or respiratory failure in non-critically ill patie...

CORRESPONDENCE Lung Transplantation for Covid-19–Related Respiratory Failure in the United States Amy Roach, Joanna Chikwe, Pedro Catarino N Engl J Med January 26, 2022DOI: 10.1056/NEJMc2117024 TO THE EDITOR: There are case reports of lung transplantation for respiratory failure due to coronavirus disease 2019 (Covid-19), but uncertainty surrounds patient selection, clinical outcomes, and the appropriateness of lung transplantation in this context.1-3 We th...

ARTICLES|ONLINE FIRST Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial Daniel I Sessler, Lijian Pei, Kai Li, et al Lancet Published:April 04, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00560-8 Summary Background Moderate intraoperative hypothermia promotes myocardial injury, surgical site infections, and blood loss. Whether aggressive war...