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Recovery after Acute Kidney Injury John A. Kellum, Florentina E. Sileanu, Azra Bihorac, et al Am J Respir Crit Care Med 2017; 195: 784-791 Rationale: 背景 Little is known about how acute kidney injury (AKI) resolves, and whether patterns of reversal of renal dysfunction differ among patients with respect to ultimate recovery. 有关急性肾损伤(AKI)的恢复过程,以及不同患者肾脏功能障碍的逆转模式知之甚少。 Objectives: 目的 We sought to examine different patterns for AKI revers...
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High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial Elizabeth Kepreotes, Bruce Whitehead, John Attia, et al Lancet 2017; 389: 930-939 Summary Background 背景 Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has...
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Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial Estelle C Nijssen, Roger J Rennenberg, Patty J Nelemans, et al Lancet 2017 (Published 20 February 2017) DOI: http://dx.doi.org/10.1016/S0140-6736(17)30057-0   Background 背景 Intravenous saline is recommended in clinical pract...
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Research Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Adrian R Martineau, David A Jolliffe, Richard L Hooper, et al. doi: https://doi.org/10.1136/bmj.i6583 (Published 15 February 2017) Cite this as: BMJ 2017;356:i6583 Abstract Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this e...
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Research Letter February 21, 2017 Website Characteristics and Physician Reviews on Commercial Physician-Rating Websites Tara Lagu, Katherine Metayer, Michael Moran; et al. JAMA. 2017;317(7):766-768. doi:10.1001/jama.2016.18553 Patients are increasingly seeking information about physicians online. Nearly 60% report that online reviews are important when choosing a physician. Because publicly reported quality data are not reported at the physician level, patients must consul...
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Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial Francisco M Marty, Joan Vidal-Puigserver, Carol Clark, et al Lancet Respir Med Published: 13 January 2017 DOI: http://dx.doi.org/10.1016/S2213-2600(16)30435-0 Background 背景 Neuraminidase inhibitors are effective for the treatment of acute uncomplicated influenza. However, there is an unmet need for intravenous treat...
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Original Investigation February 21, 2017 Effect of Fibrinogen Concentrate on Intraoperative Blood Loss Among Patients With Intraoperative Bleeding During High-Risk Cardiac SurgeryA Randomized Clinical Trial Süleyman Bilecen, Joris A. H. de Groot, Cor J. Kalkman, et al JAMA. 2017;317(7):738-747. doi:10.1001/jama.2016.21037 Abstract 摘要 Importance 背景 Fibrinogen concentrate might partly restore coagulation defects and reduce intraoperative bleeding. 纤维蛋白原可以部...
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High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial Elizabeth Kepreotes, Bruce Whitehead, John Attia, et al. Summary Background 背景 Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has not been rigorously st...
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JAMA | Original Investigation | CARING FOR THE CRITICALLY ILL PATIENT Video Laryngoscopy vs Direct Laryngoscopy on Successful First-Pass Orotracheal Intubation Among ICU Patients: A Randomized Clinical Trial Jean Baptiste Lascarrou, Julie Boisrame-Helms, Arthur Bailly, et al. JAMA. doi:10.1001/jama.2016.20603 Published online January 24, 2017. IMPORTANCE 背景 In the intensive care unit (ICU), orotracheal intubation can be associated with increased risk of complications bec...
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Articles Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial   Pierre Asfar, Frédérique Schortgen, Julie Boisramé-Helms, et al. Lancet Respir Med 2017 Available online 15 February 2017 http://dx.doi.org/10.1016/S2213-2600(17)30046-2 Summary Background 背景 There is insufficient research into the use of mechanical ventilation with increased inspiratory oxygen concentration (FiO2)...
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