ORIGINAL ARTICLE Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection Victoria Hall, Sarah Foulkes, Ferdinando Insalata, et al N Engl J Med 2022; 386:1207-1220DOI: 10.1056/NEJMoa2118691 Abstract BACKGROUND The duration and effectiveness of immunity from infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relevant to pandemic policy interventions, including the timing of vaccin...

ORIGINAL ARTICLE Homologous and Heterologous Covid-19 Booster Vaccinations Robert L. Atmar, Kirsten E. Lyke, Meagan E. Deming, et al N Engl J Med January 26, 2022DOI: 10.1056/NEJMoa2116414 Abstract BACKGROUND Although the three vaccines against coronavirus disease 2019 (Covid-19) that have received emergency use authorization in the United States are highly effective, breakthrough infections are occurring. Data are needed on the serial use of homologous ...

CORRESPONDENCE Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant Emi Takashita, Noriko Kinoshita, Seiya Yamayoshi, et al N Engl J Med January 26, 2022DOI: 10.1056/NEJMc2119407 TO THE EDITOR: In November 2021, the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in South Africa.1 Since then, omicron has rapidly spread around the world. On November 26, 2021, the World Healt...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalSurvival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort studyWhebell S. et al. Natural language processing diagnosed behavioral disturbance vs confusion assessment method for the intensive care unit: prevalence, patient characteristics, overlap, and association with treatment and outcomeYoung M. et al. OPEN ACCESS ~ Systematic ReviewPrediction of good neurologi...

Research Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) Michael Fralick, Michael Colacci, Laveena Munshi, et al BMJ 2022; 376 doi: https://doi.org/10.1136/bmj-2021-068585 (Published 23 March 2022)Cite this as: BMJ 2022;376:e068585 Abstract Objectives To assess the effectiveness of prone positioning to reduce the risk of death or respiratory failure in non-critically ill patie...

CORRESPONDENCE Lung Transplantation for Covid-19–Related Respiratory Failure in the United States Amy Roach, Joanna Chikwe, Pedro Catarino N Engl J Med January 26, 2022DOI: 10.1056/NEJMc2117024 TO THE EDITOR: There are case reports of lung transplantation for respiratory failure due to coronavirus disease 2019 (Covid-19), but uncertainty surrounds patient selection, clinical outcomes, and the appropriateness of lung transplantation in this context.1-3 We th...

ARTICLES|ONLINE FIRST Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial Daniel I Sessler, Lijian Pei, Kai Li, et al Lancet Published:April 04, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00560-8 Summary Background Moderate intraoperative hypothermia promotes myocardial injury, surgical site infections, and blood loss. Whether aggressive war...

ARTICLES|ONLINE FIRST Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 COVID-19 Excess Mortality Collaborators † Lancet Published:March 10, 2022 DOI:https://doi.org/10.1016/S0140-6736(21)02796-3 Summary Background Mortality statistics are fundamental to public health decision making. Mortality varies by time and location, and its measurement is affected by well known biases that hav...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 1, P97-111, JANUARY 01, 2022 The Usefulness of the Rapid Shallow Breathing Index in Predicting Successful Extubation: A Systematic Review and Meta-analysis Vatsal Trivedi, Dipayan Chaudhuri, Rehman Jinah, et al Chest 2022; 161: 97-111 Background Clinicians use several measures to ascertain whether individual patients will tolerate liberation from mechanical ventilation, including the rapid s...

ORIGINAL ARTICLE Effectiveness of Covid-19 Vaccines over a 9-Month Period in North Carolina Dan-Yu Lin, Yu Gu, Bradford Wheeler, et al N Engl J Med 2022; 386:933-941DOI: 10.1056/NEJMoa2117128 Abstract BACKGROUND The duration of protection afforded by coronavirus disease 2019 (Covid-19) vaccines in the United States is unclear. Whether the increase in postvaccination infections during the summer of 2021 was caused by declining immunity over time, the emer...