Research Letter February 11, 2022 Association of Homologous and Heterologous Vaccine Boosters With COVID-19 Incidence and Severity in Singapore Sharon Hui Xuan Tan, Rachael Pung, Lin-Fa Wang, et al JAMA. 2022;327(12):1181-1182. doi:10.1001/jama.2022.1922 Reports of waning antibody levels and breakthrough infections among vaccinated individuals1have prompted the recommendation for vaccine boosters to prevent SARS-CoV-2 infections. Despite more than 80% of ...

ORIGINAL ARTICLE Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit François Lamontagne, Marie-Hélène Masse, Julie Menard, et al N Engl J Med June 15, 2022DOI: 10.1056/NEJMoa2200644 Abstract BACKGROUND Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction....

ARTICLES|ONLINE FIRST Risk of hospitalisation associated with infection with SARS-CoV-2 omicron variant versus delta variant in Denmark: an observational cohort study Peter Bager, Jan Wohlfahrt, Samir Bhatt, et al Lancet Infect Dis Published:April 22, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00154-2 Summary Background Estimates of the severity of the SARS-CoV-2 omicron variant (B.1.1.529) are crucial to assess the public health impact associated...

Research Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study Adam S Lauring, Mark W Tenforde, James D Chappell, et al BMJ 2022; 376 doi: https://doi.org/10.1136/bmj-2021-069761 (Published 09 March 2022)Cite this as: BMJ 2022;376:e069761 Abstract Objectives To characterize the clinical severity of covid-19 associated with the a...

Article Monitoring SARS-CoV-2 in air and on surfaces and estimating infection risk in buildings and buses on a university campus Xin Zhang, Jianfeng Wu, Lauren M. Smith, et al J Expo Sci Environ Epidemiol (2022). 27 April 2022 https://doi.org/10.1038/s41370-022-00442-9 Abstract Background Evidence is needed on the presence of SARS-CoV-2 in various types of environmental samples and on the estimated transmission risks in non-healthcare settings on camp...

ARTICLES|ONLINE FIRST Severity of omicron variant of concern and effectiveness of vaccine boosters against symptomatic disease in Scotland (EAVE II): a national cohort study with nested test-negative design Aziz Sheikh, Steven Kerr, Mark Woolhouse, et al Lancet Infect Dis Published:April 22, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00141-4 Summary Background Since its emergence in November, 2021, in southern Africa, the SARS-CoV-2 omicron varian...

Research Letter April 8, 2022 Antibiotic Prescriptions Associated With COVID-19 Outpatient Visits Among Medicare Beneficiaries, April 2020 to April 2021 Sharon V. Tsay, Monina Bartoces, Katryna Gouin, et al JAMA. Published online April 8, 2022. doi:10.1001/jama.2022.5471 Antibiotics are ineffective treatment for viral syndromes, including COVID-19. We characterized antibiotic prescribing in older adults with outpatient COVID-19 visits to identif...

ARTICLES|ONLINE FIRST Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis Jie Li, Jian Luo, Ivan Pavlov, et al Lancet Respir Med Published: March 16, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00043-1 Summary Background Awake prone positioning has been broadly utilised for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failur...

ARTICLES| VOLUME 22, ISSUE 5, P611-621, MAY 01, 2022 Efficacy and safety of CD24Fc in hospitalised patients with COVID-19: a randomised, double-blind, placebo-controlled, phase 3 study James Welker, Juan D Pulido, Andrew T Catanzaro, et al Lancet Infect Dis 2022; 22: 611-621 Summary Background Non-antiviral therapeutic options are required for the treatment of hospitalised patients with COVID-19. CD24Fc is an immunomodulator with potential...

ARTICLES|ONLINE FIRST Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial F Jasmijn Smits, Anne Claire Henry, Marc G Besselink, et al Lancet Published:April 28, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00182-9 Summary Background Early recognition and management of postoperative complication...