ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalsEchocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)Huang S. et al. Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trialBouglé A. et al.  OPEN ACCESS ~ Special issue insightEEG monitoring after cardiac arre...

OriginalOpen AccessPublished: 16 June 2022 (1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial Frank Bloos, Jürgen Held, Stefan Kluge, et al Intensive Care Med (2022). https://doi.org/10.1007/s00134-022-06733-x Abstract Purpose To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk of invasive C...

ORIGINAL ARTICLE Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age C. Buddy Creech, Evan Anderson, Vladimir Berthaud, et al N Engl J Med May 11, 2022DOI: 10.1056/NEJMoa2203315 Abstract BACKGROUND Vaccination of children to prevent coronavirus disease 2019 (Covid-19) is an urgent public health need. The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in children 6 to 11 years of age are unknown. METHODS Part 1 o...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Lasting Legacy in Intensive Care Medicine Catheter dressingsBuetti N., Rickard C.M. and Timsit J-F. Critical care ultrasoundWong A., Robba C. and Mayo P. Prone position in mechanically ventilated patientsPapazian L., Munshi L. and Guérin C. OriginalNicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trialLabro G. et al. Pa...

ORIGINAL ARTICLE Effect of Early Treatment with Ivermectin among Patients with Covid-19 Gilmar Reis, Eduardo A.S.M. Silva, Daniela C.M. Silva, et al N Engl J Med March 30, 2022DOI: 10.1056/NEJMoa2115869 Abstract BACKGROUND The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syn...

ORIGINAL ARTICLE Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine Edson D. Moreira, Jr., Nicholas Kitchin, Xia Xu, et al N Engl J Med March 23, 2022DOI: 10.1056/NEJMoa2200674 Abstract BACKGROUND Active immunization with the BNT162b2 vaccine (Pfizer–BioNTech) has been a critical mitigation tool against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the coronavirus disease 2019 (Covid-19) pandemic. In light of...

ORIGINAL Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double‑blind randomised controlled trial Lu Ke, Jing Zhou, Wenjian Mao, et al Intensive Care Med 2022 Jun 17. doi: 10.1007/s00134-022-06745-7. Online ahead of print. Abstract Purpose: Infected pancreatic necrosis (IPN) is a highly morbid complication of acute necrotising pancreatitis (ANP). Since there is evidence of early-onset immunosuppress...

ORIGINAL ARTICLE Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine Karen J. Hager, Gonzalo Pérez Marc, Philipe Gobeil, et al N Engl J Med May 4, 2022DOI: 10.1056/NEJMoa2201300 Abstract BACKGROUND Coronavirus-like particles (CoVLP) that are produced in plants and display the prefusion spike glycoprotein of the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are combined with an adjuvant (Adjuvant ...

ORIGINAL ARTICLE Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis Joseph N. Jarvis, David S. Lawrence, David B. Meya, et al N Engl J Med 2022; 386:1109-1120DOI: 10.1056/NEJMoa2111904 Abstract BACKGROUND Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)–related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin B would be efficacious i...

ORIGINAL ARTICLE Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults Lianpan Dai, Lidong Gao, Lifeng Tao, et al N Engl J Med May 4, 2022DOI: 10.1056/NEJMoa2202261 Abstract BACKGROUND The ZF2001 vaccine, which contains a dimeric form of the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 and aluminum hydroxide as an adjuvant, was shown to be safe, with an acceptable side-effect profile, and immunogenic i...