ORIGINAL ARTICLE Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 Yair Goldberg, Micha Mandel, Yinon M. Bar-On, et al N Engl J Med May 25, 2022DOI: 10.1056/NEJMoa2118946 Abstract BACKGROUND Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides natural immunity against reinfection. Recent studies have shown waning of the immunity provided by the BNT162b2 vaccine. The time course of natural and hybrid immuni...

ARTICLES|ONLINE FIRST Global impact of the first year of COVID-19 vaccination: a mathematical modelling study Oliver J Watson, Gregory Barnsley, Jaspreet Toor, et al Lancet Infect Dis Published:June 23, 2022 DOI: https://doi.org/10.1016/S1473-3099(22)00320-6 Summary Background The first COVID-19 vaccine outside a clinical trial setting was administered on Dec 8, 2020. To ensure global vaccine equity, vaccine targets were set by the COVID-19 Vaccines G...

Original Investigation May 17, 2022 Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial Jicheng Lv, Muh Geot Wong, Michelle A. Hladunewich, et al JAMA. 2022;327(19):1888-1898. doi:10.1001/jama.2022.5368 Key Points Question  What are the effects of oral glucocorticoids in patients with IgA nephropathy and proteinuria of 1 g per day o...

CORRESPONDENCE Effectiveness of Homologous and Heterologous Covid-19 Boosters against Omicron Emma K. Accorsi, Amadea Britton, Nong Shang, et al N Engl J Med May 25, 2022DOI: 10.1056/NEJMc2203165 TO THE EDITOR: For persons who received a single dose of the Ad26.COV2.S vaccine (Johnson & Johnson–Janssen) against coronavirus disease 2019 (Covid-19), a booster dose of a messenger RNA (mRNA) vaccine at least 2 months after the primary dose is recommended. R...

ARTICLES|ONLINE FIRST Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis Nicolò Girometti, Ruth Byrne, Margherita Bracchi, et al Lancet Infect Dis Published: July 01, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00411-X Summary Background Historically, human monkeypox virus cases in the UK have been limited to imported infections f...

Original Investigation May 17, 2022 Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial The UK TAVI Trial Investigators JAMA. 2022;327(19):1875-1887. doi:10.1001/jama.2022.5776 Key Points Question  Is transcatheter aortic valve implantation (TAVI) noninferior to surgical aortic valve replacement (surgery) in patien...

ORIGINAL ARTICLEFREE PREVIEW Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A Margareth C. Ozelo, Johnny Mahlangu, K. John Pasi, et al N Engl J Med 2022; 386:1013-1025DOI: 10.1056/NEJMoa2113708 Abstract BACKGROUND Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus 5 (AAV5)–based gene-therapy vector containing a coagulation factor VIII complementary DNA driven by a liver-selective promoter. The efficacy and safety of the...

ORIGINAL ARTICLE FREE PREVIEW Tranexamic Acid in Patients Undergoing Noncardiac Surgery P.J. Devereaux, Maura Marcucci, Thomas W. Painter, et al N Engl J Med 2022; 386:1986-1997DOI: 10.1056/NEJMoa2201171 Abstract BACKGROUND Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. METHODS We conducted a trial involving patients undergoing noncardia...

Research Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study Martin Urner, Adrian G Barnett, Gianluigi Li Bassi, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-068723 (Published 04 May 2022)Cite this as: BMJ 2022;377:e068723 Abstract Objective To estimate the effect of extracorporeal membrane oxygenation (ECMO) compared with conventional mechanical ven...

ARTICLES|ONLINE FIRST Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses WHO Solidarity Trial Consortium Lancet Published:May 02, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00519-0 Summary Background The Solidarity trial among COVID-19 inpatients has previously reported interim mortality analyses for four repurposed antiviral drugs. Lopinavir, hyd...