ARTICLES|ONLINE FIRST Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case–control study Sara Y Tartof, Jeff M Slezak, Laura Puzniak, et al Lancet Respir Med Published:April 22, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00101-1 Summary Background The duration of protection against the omicron (B.1.1.529) variant for ...

ARTICLES| VOLUME 10, ISSUE 5, P447-458, MAY 01, 2022 Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis Davies Adeloye, Peige Song, Yajie Zhu, et al Lancet Respir Med 2022; 10: 447-458 Summary Background Chronic obstructive pulmonary disease (COPD) is an increasingly important cause of morbidity, disability, and mortality world...

Research Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study BMJ 2022;376:e068208 doi: https://doi.org/10.1136/bmj-2021-068208 (Published 10 March 2022) Abstract Objectives To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) to estimate mortality and disability trends for the population aged ≥70 and eval...

Research Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials BMJ 2022;376:e066785  doi: https://doi.org/10.1136/bmj-2021-066785 (Published 09 March 2022) Abstract Objective To systematically compare the effect of direct oral anticoagulants and low molecular weight heparin for thromboprophylax...

Original Investigation April 5, 2022 Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial Michela Guglieri, Kate Bushby, Michael P. McDermott, et al JAMA. 2022;327(15):1456-1468. doi:10.1001/jama.2022.4315 Key Points Question  What is the difference in clinical outcomes among 3 corticosteroid regimens (0.75 mg/kg of daily prednisone, 0.90 mg/kg of daily d...

Research Public health impact of covid-19 vaccines in the US: observational study Amitabh Bipin Suthar, Jing Wang, Victoria Seffren, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069317 (Published 27 April 2022)Cite this as: BMJ 2022;377:e069317 Abstract Objective To evaluate the impact of vaccine scale-up on population level covid-19 mortality and incidence in the United States. Design Observational study. Setting US county...

Research Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study Ioannis Katsoularis, Osvaldo Fonseca-Rodríguez, Paddy Farrington, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069590 (Published 06 April 2022)Cite this as: BMJ 2022;377:e069590 Abstract Objective To quantify the risk of deep vein thrombosis, pulmonary embolism, and bleeding after covid-1...

Original Investigation Caring for the Critically Ill PatientMay 15, 2022 Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure: A Randomized Clinical Trial Waleed Alhazzani, Ken Kuljit S. Parhar, Jason Weatherald, et al JAMA. Published online May 15, 2022. doi:10.1001/jama.2022.7993 Key Points Question  Does prone positioning reduce endotracheal intubation in adults who ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalsLong-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemiaGranholm A. et al. Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admissionOhbe H. et al. Diarrhea during critical illness: a multicenter cohort studyDionne J.C. et al. Long-term mortality and health-related quality of life of lower ver...

Original Investigation March 8, 2022 Predictive Accuracy of a Perioperative Laboratory Test–Based Prediction Model for Moderate to Severe Acute Kidney Injury After Cardiac Surgery Sevag Demirjian, C. Allen Bashour, Andrew Shaw, et al JAMA. 2022;327(10):956-964. doi:10.1001/jama.2022.1751 Key Points Question  Can a model be developed based on perioperative metabolic panel laboratory values to predict the risk of acute kidney injury (...