ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Lasting Legacy in Intensive Care Medicine Catheter dressingsBuetti N., Rickard C.M. and Timsit J-F. Critical care ultrasoundWong A., Robba C. and Mayo P. Prone position in mechanically ventilated patientsPapazian L., Munshi L. and Guérin C. OriginalNicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trialLabro G. et al. Pa...

ORIGINAL ARTICLE Effect of Early Treatment with Ivermectin among Patients with Covid-19 Gilmar Reis, Eduardo A.S.M. Silva, Daniela C.M. Silva, et al N Engl J Med March 30, 2022DOI: 10.1056/NEJMoa2115869 Abstract BACKGROUND The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syn...

ORIGINAL ARTICLE Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine Edson D. Moreira, Jr., Nicholas Kitchin, Xia Xu, et al N Engl J Med March 23, 2022DOI: 10.1056/NEJMoa2200674 Abstract BACKGROUND Active immunization with the BNT162b2 vaccine (Pfizer–BioNTech) has been a critical mitigation tool against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the coronavirus disease 2019 (Covid-19) pandemic. In light of...

ORIGINAL Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double‑blind randomised controlled trial Lu Ke, Jing Zhou, Wenjian Mao, et al Intensive Care Med 2022 Jun 17. doi: 10.1007/s00134-022-06745-7. Online ahead of print. Abstract Purpose: Infected pancreatic necrosis (IPN) is a highly morbid complication of acute necrotising pancreatitis (ANP). Since there is evidence of early-onset immunosuppress...

ORIGINAL ARTICLE Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine Karen J. Hager, Gonzalo Pérez Marc, Philipe Gobeil, et al N Engl J Med May 4, 2022DOI: 10.1056/NEJMoa2201300 Abstract BACKGROUND Coronavirus-like particles (CoVLP) that are produced in plants and display the prefusion spike glycoprotein of the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are combined with an adjuvant (Adjuvant ...

ORIGINAL ARTICLE Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis Joseph N. Jarvis, David S. Lawrence, David B. Meya, et al N Engl J Med 2022; 386:1109-1120DOI: 10.1056/NEJMoa2111904 Abstract BACKGROUND Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)–related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin B would be efficacious i...

ORIGINAL ARTICLE Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults Lianpan Dai, Lidong Gao, Lifeng Tao, et al N Engl J Med May 4, 2022DOI: 10.1056/NEJMoa2202261 Abstract BACKGROUND The ZF2001 vaccine, which contains a dimeric form of the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 and aluminum hydroxide as an adjuvant, was shown to be safe, with an acceptable side-effect profile, and immunogenic i...

Original Investigation May 2, 2022 Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes Elisabeth McClymont, Arianne Y. Albert, Gillian D. Alton, et al JAMA. Published online May 2, 2022. doi:10.1001/jama.2022.5906 Key Points Question  Is SARS-CoV-2 infection during pregnancy associated with increased risk of adverse maternal and perinatal outcomes? Findings  This Canadian surveillan...

ORIGINAL ARTICLE Restriction of Intravenous Fluid in ICU Patients with Septic Shock T.S. Meyhoff, P.B. Hjortrup, J. Wetterslev, et al N Engl J Med June 17, 2022DOI: 10.1056/NEJMoa2202707 BACKGROUND Intravenous fluids are recommended for the treatment of patients who are in septic shock, but higher fluid volumes have been associated with harm in patients who are in the intensive care unit (ICU). METHODS In this international, randomized trial, we ...

Original Investigation May 5, 2022 Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany Gordian J. Hubert, Nikolai D. Hubert, Christian Maegerlein, et al JAMA. 2022;327(18):1795-1805. doi:10.1001/jama.2022.5948 Key Points Question  In a nonurban region in Germany, is the deployment of a flying intervention tea...