Research Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study Isobel L Ward, Charlotte Bermingham, Daniel Ayoubkhani, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070695 (Published 02 August 2022)Cite this as: BMJ 2022;378:e070695 Abstract Objective To assess the risk of covid-19 death after infection with omicron BA.1 compared with delta (B.1.617.2). Design ...

Research Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records Elsie M F Horne, William J Hulme, Ruth H Keogh, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071249 (Published 20 July 2022)Cite this as: BMJ 2022;378:e071249 Abstract Objective To estimate waning of covid-19 vaccine effectiveness over six months after second dose. Desi...

Original Investigation  September 6, 2022 Effect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Randomized Clinical Trial Matthew T. James, Bryan J. Har, Benjamin D. Tyrrell, et al JAMA. 2022;328(9):839-849. doi:10.1001/jama.2022.13382 Key Points Question  What is the effectiveness of clinical decision support, accompanied by audit and feedb...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P346-355, AUGUST 01, 2022 Defibrotide Therapy for SARS-CoV-2 ARDS David Frame, Gianni B. Scappaticci, Thomas M. Braun, et al Chest 2022; 162: 346-355 Published:April 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.03.046 Background SARS-CoV-2-related ARDS is associated with endothelial dysfunction and profound dysregulation of the thrombotic-fibrinolytic pathway. Defibrotide is a pol...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P356-366, AUGUST 01, 2022 Targeted Temperature Management After In-Hospital Cardiac Arrest: An Ancillary Analysis of Targeted Temperature Management for Cardiac Arrest With Nonshockable Rhythm Trial Data Alexiane Blanc, Gwenhael Colin, Alain Cariou, et al Chest 2022; 162: 356-366 Published:March 19, 2022 DOI:https://doi.org/10.1016/j.chest.2022.02.056 Background Targeted temperature ma...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P331-345, AUGUST 01, 2022 The Influence of the COVID-19 Pandemic on Intensivists’ Well-Being: A Qualitative Study Kelly C. Vranas, Sara E. Golden, Shannon Nugent, et al Chest 2022; 162: 331-345 Published:May 11, 2022 DOI:https://doi.org/10.1016/j.chest.2022.05.003 Background The COVID-19 pandemic has strained health care systems and has resulted in widespread critical care staffing sho...

ARTICLES|ONLINE FIRST Phenotyping of idiopathic pulmonary arterial hypertension: a registry analysis Marius M Hoeper, Krit Dwivedi, Christine Pausch, et al. Lancet Respir Med Published:June 28, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00097-2 Summary Background Among patients meeting diagnostic criteria for idiopathic pulmonary arterial hypertension (IPAH), there is an emerging lung phenotype characterised by a low diffusion capacity f...

ARTICLES|ONLINE FIRST Association between women's authorship and women's editorship in infectious diseases journals: a cross-sectional study Katharina Last, Lilith Hübsch, Muge Cevik, et al. Lancet Infect Dis Published:July 12, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00367-X Summary Background Gender inequity is still pervasive in academic medicine, including journal publishing. We aimed to ascertain the proportion of women among first and last...

ARTICLES|ONLINE FIRST Impact of interactive computerised decision support for hospital antibiotic use (COMPASS): an open-label, cluster-randomised trial in three Swiss hospitals Gaud Catho, Julien Sauser, Valentina Coray, et al. Lancet Infect Dis Published:July 20, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00308-5 Summary Background Computerised decision-support systems (CDSSs) for antibiotic stewardship could help to assist physicians in the app...

ARTICLES| VOLUME 400, ISSUE 10349, P359-368, JULY 30, 2022 Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis RECOVERY Collaborative Group Lancet 2022; 400: 359-368 Published:July 30, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)01109-6 Summary Background We aimed to evaluate the use of baricitinib, a Janus kinase (JAK) 1–2 inhibitor, fo...