ORIGINAL ARTICLE Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction Scott D. Solomon, John J.V. McMurray, Brian Claggett, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2206286 Abstract BACKGROUND Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure and cardiovascular death among patients with chronic heart failure and a left ventricular ejection fraction of 40% or les...

ORIGINAL ARTICLE Acetazolamide in Acute Decompensated Heart Failure with Volume Overload Wilfried Mullens, Jeroen Dauw, Pieter Martens, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2203094 Abstract BACKGROUND Whether acetazolamide, a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption, can improve the efficiency of loop diuretics, potentially leading to more and faster decongestion in patients with acute decompensated h...

ORIGINAL ARTICLE Rivaroxaban in Rheumatic Heart Disease–Associated Atrial Fibrillation Stuart J. Connolly, Ganesan Karthikeyan, Mpiko Ntsekhe, et al N Engl J Med August 28, 2022DOI: 10.1056/NEJMoa2209051 Abstract BACKGROUND Testing of factor Xa inhibitors for the prevention of cardiovascular events in patients with rheumatic heart disease–associated atrial fibrillation has been limited. METHODS We enrolled patients with atrial fibrillation and echo...

ORIGINAL ARTICLE Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction Divaka Perera, Tim Clayton, Peter D. O’Kane, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2206606 Abstract BACKGROUND Whether revascularization by percutaneous coronary intervention (PCI) can improve event-free survival and left ventricular function in patients with severe ischemic left ventricular systolic dysfunction, as compared with optimal medical thera...

ORIGINAL ARTICLE Oxygen Targets in Comatose Survivors of Cardiac Arrest Henrik Schmidt, Jesper Kjaergaard, Christian Hassager, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2208686 Abstract BACKGROUND The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown. METHODS In this randomized trial with a 2-by-2 factorial design, we randomly assigned comatose adults with out-of-...

ORIGINAL ARTICLE Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Jesper Kjaergaard, Jacob E. Møller, Henrik Schmidt, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2208687 Abstract BACKGROUND Evidence to support the choice of blood-pressure targets for the treatment of comatose survivors of out-of-hospital cardiac arrest who are receiving intensive care is limited. METHODS In a double-blind, randomized trial with a 2-by-2 facto...

Original Investigation  August 10, 2022 Effect of Etomidate vs Propofol for Total Intravenous Anesthesia on Major Postoperative Complications in Older Patients: A Randomized Clinical Trial Zhihong Lu, Hong Zheng, Zhijun Chen, et al JAMA Surg. Published online August 10, 2022. doi:10.1001/jamasurg.2022.3338 Key Points Question  Does etomidate compared with propofol provide a noninferior effect on...

Original Investigation  August 17, 2022 Association of Prehospital Needle Decompression With Mortality Among Injured Patients Requiring Emergency Chest Decompression Daniel Muchnok, Allison Vargo, Andrew-Paul Deeb, et al JAMA Surg. Published online August 17, 2022. doi:10.1001/jamasurg.2022.3552 Key Points Question  Is prehospital needle decompression (PHND) associated with lower 24-hour mortality among trauma patients requiring ...

ORIGINAL ARTICLE Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge Ronen Arbel, Yael Wolff Sagy, Moshe Hoshen, et al N Engl J Med August 24, 2022DOI: 10.1056/NEJMoa2204919 Abstract BACKGROUND The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data regarding the effective...

US Preventive Services Task Force  Evidence Report August 23/30, 2022 Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force Roger Chou, Amy Cantor, Tracy Dana, et al JAMA. 2022;328(8):754-771. doi:10.1001/jama.2022.12138 Abstract Importance  A 2016 review for the US Preventive Services Task Force (USPSTF) found use of s...