ORIGINAL ARTICLE Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece Arnaud W. Thille, Arnaud Gacouin, Rémi Coudroy, et al N Engl J Med October 26, 2022DOI: 10.1056/NEJMoa2209041 BACKGROUND Spontaneous-breathing trials can be performed with the use of either pressure-support ventilation (PSV) or a T-piece. Whether PSV trials may result in a shorter time to tracheal extubation than T-piece trials, without resulting in a higher risk of...

Research External validation of a prediction model for estimating fat mass in children and adolescents in 19 countries: individual participant data meta-analysis Mohammed T Hudda, Jonathan C K Wells,  Linda S Adair, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071185 (Published 21 September 2022)Cite this as: BMJ 2022;378:e071185 Abstract Objective To evaluate the performance of a UK based prediction model for estimating fat-free mass (and...

Research Effectiveness of a behavioural intervention delivered by text messages (safetxt) on sexually transmitted reinfections in people aged 16-24 years: randomised controlled trial Caroline Free, Melissa J Palmer, Ona L McCarthy, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070351 (Published 28 September 2022)Cite this as: BMJ 2022;378:e070351 Abstract Objective To quantify the effects of a series of text messages (safetxt) delivered in ...

Research Comparison of short term surgical outcomes of male and female gastrointestinal surgeons in Japan: retrospective cohort study Kae Okoshi, Hideki Endo, Sachiyo Nomura, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070568 (Published 28 September 2022)Cite this as: BMJ 2022;378:e070568 Abstract Objective To compare short term surgical outcomes between male and female gastrointestinal surgeons in Japan. Design Retrospective coho...

Research Letter  August 22, 2022 Compassionate Use of Tecovirimat for the Treatment of Monkeypox Infection Angel N. Desai, George R. Thompson III, Sonja M. Neumeister, et al JAMA. 2022;328(13):1348-1350. doi:10.1001/jama.2022.15336 Monkeypox is a zoonotic orthopoxvirus in the same genus as variola (the causative agent of smallpox).1 A recent global outbreak has led to more than 39 000 cases reported as of August 18, 2022.2 Monkeypox is typica...

Original Investigation  October 4, 2022 Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial The NO PAin Investigators JAMA. 2022;328(13):1326-1335. doi:10.1001/jama.2022.16844 Key Points Question  Does a multimodal opioid-sparing postoperative pain protocol reduce postoperative opioid consump...

Original Investigation  October 4, 2022 Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial Keith S. Kaye, Adam Belley, Philip Barth, et al JAMA. 2022;328(13):1304-1314. doi:10.1001/jama.2022.17034 Key Points Question  How does the efficacy of cefepime/enmetazobactam c...

ORIGINAL RESEARCH|ARTICLES IN PRESS Recall of awareness during paralysis among emergency department patients undergoing tracheal intubation Brian E. Driver, Matthew E. Prekker, Emily Wagner, et al Chest Published:September 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.08.2232 ABSTRACT Background Critically ill patients sometimes remember periods of neuromuscular blockade. Research Question What is the prevalence of recalled awareness during ...

ARTICLES|ONLINE FIRST Artificial intelligence-guided screening for atrial fibrillation using electrocardiogram during sinus rhythm: a prospective non-randomised interventional trial Peter A Noseworthy, Zachi I Attia, Emma M Behnken, et al  Lancet Published:September 27, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)01637-3 Summary Background Previous atrial fibrillation screening trials have highlighted the need for more targeted approaches. We did a...

ORIGINAL ARTICLE A Bivalent Omicron-Containing Booster Vaccine against Covid-19 Spyros Chalkias, Charles Harper, Keith Vrbicky, et al N Engl J Med September 16, 2022DOI: 10.1056/NEJMoa2208343 Abstract BACKGROUND The safety and immunogenicity of the bivalent omicron-containing mRNA-1273.214 booster vaccine are not known. METHODS In this ongoing, phase 2–3 study, we compared the 50-μg bivalent vaccine mRNA-1273.214 (25 μg each of ancestral Wuhan-Hu-1...