ORIGINAL ARTICLE Phase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B Pratima Chowdary, Susan Shapiro, Mike Makris, et al N Engl J Med 2022; 387:237-247DOI: 10.1056/NEJMoa2119913 Abstract BACKGROUND FLT180a (verbrinacogene setparvovec) is a liver-directed adeno-associated virus (AAV) gene therapy that uses a synthetic capsid and a gain-of-function protein to normalize factor IX levels in patients with hemophilia B. METHODS In thi...

ORIGINAL ARTICLE Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 John P. Thornhill, Sapha Barkati, Sharon Walmsley, et al N Engl J Med July 21, 2022DOI: 10.1056/NEJMoa2207323 Abstract BACKGROUND Before April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infectio...

ORIGINAL ARTICLE BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age Chandra J. Cohen-Stavi, Ori Magen, Noam Barda, et al N Engl J Med 2022; 387:227-236DOI: 10.1056/NEJMoa2205011 Abstract BACKGROUND Limited evidence is available on the real-world effectiveness of the BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) and specifically against infection with the omicron variant among children 5 to 11 years of age. M...

Research Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study Daniel Ayoubkhani, Charlotte Bermingham, Koen B Pouwels, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069676 (Published 18 May 2022)Cite this as: BMJ 2022;377:e069676 Abstract Objective To estimate associations between covid-19 vaccination and long covid symptoms in adults with SARS-CoV-2 infection bef...

Original Investigation  July 19, 2022 Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial Gregory D. Lewis, Adriaan A. Voors, Alain Cohen-Solal, et al JAMA. 2022;328(3):259-269. doi:10.1001/jama.2022.11016 Key Points Question  Does omecamtiv mecarbil, a novel cardiac myosin activator, improve exercise capacity in patients with heart f...

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 161, ISSUE 5, P1201-1210, MAY 01, 2022 Primary Prophylaxis for Pneumocystis jirovecii Pneumonia in Patients Receiving Rituximab Jun Won Park, Jeffrey R. Curtis, Kang Il Jun, et al Chest 2022; 161: 1201-1210 Background Although previous studies suggested that rituximab increases the risk of Pneumocystis jirovecii pneumonia (PJP), it is uncertain whether its primary prophylaxis for PJP is ju...

ARTICLES| VOLUME 3, ISSUE 6, E443-E451, JUNE 01, 2022 Gut colonisation by extended-spectrum β-lactamase-producing Escherichia coli and its association with the gut microbiome and metabolome in Dutch adults: a matched case-control study Quinten R Ducarmon, Romy D Zwittink, Roel P J Willems, et al. Lancet Microbe 2022; 3: E443-E451 Published:April 20, 2022 DOI:https://doi.org/10.1016/S2666-5247(22)00037-4 Summary Background Gut colonisati...

ORIGINAL ARTICLE Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns Yvonne W. Wu, Bryan A. Comstock, Fernando F. Gonzalez, et al N Engl J Med 2022; 387:148-159DOI: 10.1056/NEJMoa2119660 Abstract BACKGROUND Neonatal hypoxic–ischemic encephalopathy is an important cause of death as well as long-term disability in survivors. Erythropoietin has been hypothesized to have neuroprotective effects in infants with hypoxic–ischemic encephalopa...

ORIGINAL ARTICLE Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants Natasha B. Halasa, Samantha M. Olson, Mary A. Staat, et al N Engl J Med 2022; 387:109-119DOI: 10.1056/NEJMoa2204399 Abstract BACKGROUND Infants younger than 6 months of age are at high risk for complications of coronavirus disease 2019 (Covid-19) and are not eligible for vaccination. Transplacental transfer of antibodies against severe acute respiratory syndrome ...

Research Letter  June 29, 2022 Internet Searches for Abortion Medications Following the Leaked Supreme Court of the United States Draft Ruling Adam Poliak, Nora Satybaldiyeva, Steffanie A. Strathdee, et al JAMA Intern Med. Published online June 29, 2022. doi:10.1001/jamainternmed.2022.2998 On May 2, 2022, a draft Supreme Court of the United States (SCOTUS) majority opinion was leaked,1 foreshadowing the decision to overturn the 1973 ...