ORIGINAL ARTICLE Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction Divaka Perera, Tim Clayton, Peter D. O’Kane, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2206606 Abstract BACKGROUND Whether revascularization by percutaneous coronary intervention (PCI) can improve event-free survival and left ventricular function in patients with severe ischemic left ventricular systolic dysfunction, as compared with optimal medical thera...

ORIGINAL ARTICLE Oxygen Targets in Comatose Survivors of Cardiac Arrest Henrik Schmidt, Jesper Kjaergaard, Christian Hassager, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2208686 Abstract BACKGROUND The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown. METHODS In this randomized trial with a 2-by-2 factorial design, we randomly assigned comatose adults with out-of-...

ORIGINAL ARTICLE Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Jesper Kjaergaard, Jacob E. Møller, Henrik Schmidt, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2208687 Abstract BACKGROUND Evidence to support the choice of blood-pressure targets for the treatment of comatose survivors of out-of-hospital cardiac arrest who are receiving intensive care is limited. METHODS In a double-blind, randomized trial with a 2-by-2 facto...

Original Investigation  August 10, 2022 Effect of Etomidate vs Propofol for Total Intravenous Anesthesia on Major Postoperative Complications in Older Patients: A Randomized Clinical Trial Zhihong Lu, Hong Zheng, Zhijun Chen, et al JAMA Surg. Published online August 10, 2022. doi:10.1001/jamasurg.2022.3338 Key Points Question  Does etomidate compared with propofol provide a noninferior effect on...

Original Investigation  August 17, 2022 Association of Prehospital Needle Decompression With Mortality Among Injured Patients Requiring Emergency Chest Decompression Daniel Muchnok, Allison Vargo, Andrew-Paul Deeb, et al JAMA Surg. Published online August 17, 2022. doi:10.1001/jamasurg.2022.3552 Key Points Question  Is prehospital needle decompression (PHND) associated with lower 24-hour mortality among trauma patients requiring ...

ORIGINAL ARTICLE Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge Ronen Arbel, Yael Wolff Sagy, Moshe Hoshen, et al N Engl J Med August 24, 2022DOI: 10.1056/NEJMoa2204919 Abstract BACKGROUND The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data regarding the effective...

US Preventive Services Task Force  Evidence Report August 23/30, 2022 Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force Roger Chou, Amy Cantor, Tracy Dana, et al JAMA. 2022;328(8):754-771. doi:10.1001/jama.2022.12138 Abstract Importance  A 2016 review for the US Preventive Services Task Force (USPSTF) found use of s...

ARTICLES|ONLINE FIRST Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study Seran Hakki, Jie Zhou, Jakob Jonnerby, et al Lancet Respir Med Published: August 18, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00226-0 Summary Background Knowledge of the window of SARS-CoV-2 infectiousness is crucial in developing policies to curb transmission. Mathematical modelling...

Original Investigation  August 23/30, 2022 Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial CRISTAL Study Group JAMA. 2022;328(8):719-727. doi:10.1001/jama.2022.13416 Key Points Question  Is aspirin monotherapy noninferior to enoxaparin in preventing symptomatic venous thromboembolism (VTE) within 90 days following primary total hip...

ORIGINAL ARTICLE Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes Caroline A. Crowther, Deborah Samuel, Lesley M.E. McCowan, et al N Engl J Med 2022; 387:587-598DOI: 10.1056/NEJMoa2204091 Abstract BACKGROUND Treatment of gestational diabetes improves maternal and infant health, although diagnostic criteria remain unclear. METHODS We randomly assigned women at 24 to 32 weeks’ gestation in a 1:1 ratio to be evaluated for ge...