ARTICLES|ONLINE FIRST Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial Ingrid M Bistervels, Andrea Buchmüller, Hanke M G Wiegers, et al Lancet Published:October 28, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02128-6 Summary Background Pregnancy-related venous thromboembolism is a leading...

ARTICLES|ONLINE FIRST Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial Pengfei Yang, Lili Song, Yongwei Zhang, et al Lancet Published:October 27, 2022 DOI: https://doi.org/10.1016/S0140-6736(22)01882-7 Summary Background The optimum systolic blood pressure after endovascular thrombectomy for acute ischaemic stroke is unc...

ARTICLES| VOLUME 400, ISSUE 10359, P1213-1222, OCTOBER 08, 2022 Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study Carlos K H Wong, Ivan C H Au, Kristy T K Lau, et al Lancet 2022; 400: 1213-1222 Published:October 08, 2022 D...

Research Association between initiation of fluoroquinolones and hospital admission or emergency department visit for suicidality: population based cohort study Junyi Wang, Joshua J Gagne, Sushama Kattinakere-Sreedhara, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2021-069931 (Published 04 October 2022)Cite this as: BMJ 2022;379:e069931 Abstract Objective To evaluate the association between initiation of fluoroquinolones and hospital admission o...

Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial Gary A Herman, Meagan P O'Brien, Eduardo Forleo-Neto, et al Lancet Infect Dis 2022; 22: 1444-1454 Summary Background There is an unmet need for COVID-19 prevention in patient populations who have not mounted or are not expected to mount an adequate immune response to complete C...

ARTICLES| VOLUME 22, ISSUE 10, P1435-1443, OCTOBER 01, 2022 Vaccine effectiveness of one, two, and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong: a population-based observational study Martina E McMenamin, Joshua Nealon, Yun Lin, et al Lancet Infect Dis 2022; 22: 1435-1443 Summary Background Hong Kong maintained low circulation of SARS-CoV-2 until a major community epidemic of the omicron (B.1.1.529) sublineage BA.2 b...

ORIGINAL ARTICLEFREE PREVIEW Trial of Intravenous Immune Globulin in Dermatomyositis Rohit Aggarwal, Christina Charles-Schoeman, Joachim Schessl, et al N Engl J Med 2022; 387:1264-1278DOI: 10.1056/NEJMoa2117912 Abstract BACKGROUND Intravenous immune globulin (IVIG) for the treatment of dermatomyositis has not been extensively evaluated. METHODS We conducted a randomized, placebo-controlled trial involving patients with active dermatomyositis. The p...

ORIGINAL ARTICLE Racial and Ethnic Differences in Bystander CPR for Witnessed Cardiac Arrest R. Angel Garcia, John A. Spertus, Saket Girotra, et al N Engl J Med 2022; 387:1569-1578DOI: 10.1056/NEJMoa2200798 Abstract BACKGROUND Differences in the incidence of cardiopulmonary resuscitation (CPR) provided by bystanders contribute to survival disparities among persons with out-of-hospital cardiac arrest. It is critical to understand whether the incidence of ...

ORIGINAL RESEARCH|ARTICLES IN PRESS High-Dose Intravenous Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The IV-HOCSS Trial) Jayshil J. Patel, Rodney Willoughby, Jennifer Peterson, et al Chest Published:September 26, 2022 DOI:https://doi.org/10.1016/j.chest.2022.09.021 Abstract Background Elevated hydrogen sulfide (H2S) contributes to vasodilatat...

DIFFUSE LUNG DISEASE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 4, P815-823, OCTOBER 01, 2022 Predicting Usual Interstitial Pneumonia Histopathology From Chest CT Imaging With Deep Learning Alex Bratt, James M. Williams, Grace Liu, MD  Chest 2022; 162: 815-823 Published: April 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.03.044 Background Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal form of interstitial lung disease (I...