Original Investigation  September 8, 2022 Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial Mandeep R. Mehra, Daniel J. Goldstein, Joseph C. Cleveland, et al JAMA. Published online September 8, 2022. doi:10.1001/jama.2022.16197 Key Points Question  In patients with advanced heart failure, what is the difference in the composite end poi...

Research Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) David A Jolliffe, Hayley Holt, Matthew Greenig, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071230 (Published 07 September 2022)Cite this as: BMJ 2022;378:e071230 Abstract Objective To determine the effect of population level implementation of a test-...

Original Investigation  August 26, 2022 Concordance of SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents Jesse J. Waggoner, Miriam B. Vos, Erika A. Tyburski, et al JAMA. Published online August 26, 2022. doi:10.1001/jama.2022.14877 Key Points Question  Are children and adolescents, aged 4 to 14 years, able to adequately self-collect nasal swabs for SARS-CoV-2 te...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalExtubation in neurocritical care patients: the ENIO international prospective studyCinotti R. et al. Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG studyPéju E. et al. Mental health-related quality of life is related to delirium in intensive care patientsHofhuis J.G.M., Schermer T. and S...

ORIGINAL ARTICLE Efficacy and Safety of an Extravascular Implantable Cardioverter–Defibrillator Paul Friedman, Francis Murgatroyd, Lucas V.A. Boersma, et al N Engl J Med August 28, 2022DOI: 10.1056/NEJMoa2206485 Abstract BACKGROUND The extravascular implantable cardioverter–defibrillator (ICD) has a single lead implanted substernally to enable pause-prevention pacing, antitachycardia pacing, and defibrillation energy similar to that of transvenous ICDs. ...

ORIGINAL ARTICLE Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI Bon-Kwon Koo, Xinyang Hu, Jeehoon Kang, et al N Engl J Med 2022; 387:779-789DOI: 10.1056/NEJMoa2201546 Abstract BACKGROUND In patients with coronary artery disease who are being evaluated for percutaneous coronary intervention (PCI), procedures can be guided by fractional flow reserve (FFR) or intravascular ultrasonography (IVUS) for decision making regarding revascula...

ORIGINAL ARTICLE Routine Functional Testing or Standard Care in High-Risk Patients after PCI Duk-Woo Park, Do-Yoon Kang, Jung-Min Ahn, et al N Engl J Med August 28, 2022DOI: 10.1056/NEJMoa2208335 Abstract BACKGROUND There are limited data from randomized trials to guide a specific follow-up surveillance approach after myocardial revascularization. Whether a follow-up strategy that includes routine functional testing improves clinical outcomes among high-...

ORIGINAL ARTICLE Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction Scott D. Solomon, John J.V. McMurray, Brian Claggett, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2206286 Abstract BACKGROUND Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure and cardiovascular death among patients with chronic heart failure and a left ventricular ejection fraction of 40% or les...

ORIGINAL ARTICLE Acetazolamide in Acute Decompensated Heart Failure with Volume Overload Wilfried Mullens, Jeroen Dauw, Pieter Martens, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2203094 Abstract BACKGROUND Whether acetazolamide, a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption, can improve the efficiency of loop diuretics, potentially leading to more and faster decongestion in patients with acute decompensated h...

ORIGINAL ARTICLE Rivaroxaban in Rheumatic Heart Disease–Associated Atrial Fibrillation Stuart J. Connolly, Ganesan Karthikeyan, Mpiko Ntsekhe, et al N Engl J Med August 28, 2022DOI: 10.1056/NEJMoa2209051 Abstract BACKGROUND Testing of factor Xa inhibitors for the prevention of cardiovascular events in patients with rheumatic heart disease–associated atrial fibrillation has been limited. METHODS We enrolled patients with atrial fibrillation and echo...