ORIGINAL ARTICLE Trial of an Intervention to Improve Acute Heart Failure Outcomes Douglas S. Lee, Sharon E. Straus, Michael E. Farkouh, et al N Engl J Med November 5, 2022DOI: 10.1056/NEJMoa2211680 Abstract BACKGROUND Patients with acute heart failure are frequently or systematically hospitalized, often because the risk of adverse events is uncertain and the options for rapid follow-up are inadequate. Whether the use of a strategy to support clinicians i...

ORIGINAL ARTICLE Methylprednisolone for Heart Surgery in Infants — A Randomized, Controlled Trial Kevin D. Hill, Prince J. Kannankeril, Jeffrey P. Jacobs, et al N Engl J Med November 6, 2022DOI: 10.1056/NEJMoa2212667 Abstract BACKGROUND Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown. METHODS We conducted a multicenter...

ORIGINAL ARTICLE Duration of Device-Based Fever Prevention after Cardiac Arrest Christian Hassager, Henrik Schmidt, Jacob E. Møller, et al N Engl J Med November 6, 2022DOI: 10.1056/NEJMoa2212528 Abstract BACKGROUND Guidelines recommend active fever prevention for 72 hours after cardiac arrest. Data from randomized clinical trials of this intervention have been lacking. METHODS We randomly assigned comatose patients who had been resuscitated after a...

ORIGINAL ARTICLE Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia Alik Farber, Matthew T. Menard, Michael S. Conte, et al N Engl J Med November 7, 2022DOI: 10.1056/NEJMoa2207899 Abstract BACKGROUND Patients with chronic limb-threatening ischemia (CLTI) require revascularization to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an initial strategy of endovascular therapy or surgical revascular...

Original Investigation  November 6, 2022 Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 James G. Jollis, Christopher B. Granger, Jessica K. Zègre-Hemsey, et al JAMA. Published online November 6, 2022. doi:10.1001/jama.2022.20149 Key Points Question  What were the treatment times and in-hospital mortality among US patients with ST-segment elevation myocardial infa...

Research Clinical and cost effectiveness of single stage compared with two stage revision for hip prosthetic joint infection (INFORM): pragmatic, parallel group, open label, randomised controlled trial Ashley W Blom, Erik Lenguerrand, Simon Strange, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071281 (Published 31 October 2022)Cite this as: BMJ 2022;379:e071281 Abstract Objectives To determine whether patient reported outcomes improve afte...

Original Investigation  November 3, 2022 Association Between Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease Vikram Fielding-Singh, Matthew W. Vanneman, Tristan Grogan, et al JAMA. 2022;328(18):1837-1848. doi:10.1001/jama.2022.19626 Key Points Question  Is there an association between the timing of preoperative hemodialysis relative to surgery and postoperative mortality in patients wi...

Research Novel antihyperglycaemic drugs and prevention of chronic obstructive pulmonary disease exacerbations among patients with type 2 diabetes: population based cohort study Richeek Pradhan, Sally Lu, Hui Yin, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071380 (Published 01 November 2022)Cite this as: BMJ 2022;379:e071380 Abstract Objective To determine whether the use of glucagon-like peptide 1 (GLP-1) receptor agonists, dipeptidyl pe...

ARTICLES|ONLINE FIRST Antibiotic review kit for hospitals (ARK-Hospital): a stepped-wedge cluster-randomised controlled trial Martin J Llewelyn, Eric P Budgell, Magda Laskawiec-Szkonter, et al Lancet Infect Dis Published:October 04, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00508-4 Summary Background Strategies to reduce antibiotic overuse in hospitals depend on prescribers taking decisions to stop unnecessary antibiotic use. There is scarce evid...

Research Effect of oral antimicrobial prophylaxis on surgical site infection after elective colorectal surgery: multicentre, randomised, double blind, placebo controlled trial Emmanuel Futier, Samir Jaber, Matthias Garot, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071476 (Published 03 November 2022)Cite this as: BMJ 2022;379:e071476 Abstract Objective To investigate whether oral antimicrobial prophylaxis as an adjunct to intravenous anti...