ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalImpact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trialBagshaw S.M. et al.OPEN ACCESS ~ OriginalModel-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trialEwoldt T.M.J. et al.Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study...

Original Investigation  November 30, 2022 Association Between Hemorrhage Control Interventions and Mortality in US Trauma Patients With Hemodynamically Unstable Pelvic Fractures Tanya Anand, Khaled El-Qawaqzeh, Adam Nelson, et al JAMA Surg. Published online November 30, 2022. doi:10.1001/jamasurg.2022.5772 Question  What is the current variation in nationwide practices for the management of pelvic fracture–related hemorrhage? Fin...

Research Letter  November 28, 2022 Analysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center Scott C. Roberts, Ridwan N. Faruq, Anne K. Wilkinson, et al JAMA Intern Med. Published online November 28, 2022. doi:10.1001/jamainternmed.2022.5426 Many health care facilities use entrance screening to prevent individuals with acute COVID-19 from entering. In ambulatory settings, 1 study found failures (defined as an e...

β-Lactam–Resistant Streptococcus pneumoniae Dynamics Following Treatment: A Dose-Response Meta-analysis  Matas Griskaitis,  Luis Furuya-Kanamori,  Kasim Allel,  et al Clinical Infectious Diseases, Volume 75, Issue 11, 1 December 2022, Pages 1962–1970, https://doi.org/10.1093/cid/ciac293 Abstract Background Patient exposure to antibiotics promotes the emergence of drug-resistant pathogens. The aim of this study was to identify whether the temporal dynamics o...

Research Oxygen administration during surgery and postoperative organ injury: observational cohort study David R McIlroy, Matthew S Shotwell, Marcos G Lopez, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-070941 (Published 30 November 2022)Cite this as: BMJ 2022;379:e070941 Abstract Objective To examine whether supraphysiological oxygen administration during surgery is associated with lower or higher postoperative kidney, heart, and lung inj...

Endgames Christmas 2022: Brain Stew Misspelling of antimicrobials by healthcare professionals Daniel Weiand, Joanna Lumb BMJ 2022; 379 doi: https://doi.org/10.1136/bmj.o2946 (Published 19 December 2022)Cite this as: BMJ 2022;379:o2946 Although electronic health records have widely reduced medication errors, and computerised hospital orders are an undeniable step-up in clarity from illegible handwritten orders,1234 they are not a patient safety panace...

Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease Takafumi Kato,  Takanori Asakura,  Caitlin E. Edwards, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1336-1352. doi: 10.1164/rccm.202111-2606OC Abstract Rationale: The incidence and sites of mucus accumulation and molecular regulation of mucin gene expression in coronavirus (COVID-19) lung disease have not been reported. Objectives: To characterize the incidence of mu...

Research Christmas 2022: Physical Quantifying the benefits of inefficient walking: Monty Python inspired laboratory based experimental study Glenn A Gaesser, David C Poole, Siddhartha S Angadi BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072833 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072833 Abstract Objective To compare the rate of energy expenditure of low efficiency walking with high efficiency walking. Design Labo...

Sex Differences in Mortality of ICU Patients According to Diagnosis-related Sex Balance Lucy J. Modra,  Alisa M. Higgins,  David V. Pilcher, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1353-1360. doi: 10.1164/rccm.202203-0539OC. Abstract Rationale: Women have worse outcomes than men in several conditions more common in men, including cardiac surgery and burns. Objectives: To describe the relationship between sex balance within each diagnost...

Research Christmas 2022: Physical Digital disparities among healthcare workers in typing speed between generations, genders, and medical specialties: cross sectional study Alex R Schuurman, M E Baarsma, W Joost Wiersinga, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072784 (Published 19 December 2022)Cite this as: BMJ 2022;379:e072784 Abstract Objective To investigate the typing skills of healthcare professionals. Design Cross...