Research Association between initiation of fluoroquinolones and hospital admission or emergency department visit for suicidality: population based cohort study Junyi Wang, Joshua J Gagne, Sushama Kattinakere-Sreedhara, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2021-069931 (Published 04 October 2022)Cite this as: BMJ 2022;379:e069931 Abstract Objective To evaluate the association between initiation of fluoroquinolones and hospital admission o...

Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial Gary A Herman, Meagan P O'Brien, Eduardo Forleo-Neto, et al Lancet Infect Dis 2022; 22: 1444-1454 Summary Background There is an unmet need for COVID-19 prevention in patient populations who have not mounted or are not expected to mount an adequate immune response to complete C...

ARTICLES| VOLUME 22, ISSUE 10, P1435-1443, OCTOBER 01, 2022 Vaccine effectiveness of one, two, and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong: a population-based observational study Martina E McMenamin, Joshua Nealon, Yun Lin, et al Lancet Infect Dis 2022; 22: 1435-1443 Summary Background Hong Kong maintained low circulation of SARS-CoV-2 until a major community epidemic of the omicron (B.1.1.529) sublineage BA.2 b...

ORIGINAL ARTICLEFREE PREVIEW Trial of Intravenous Immune Globulin in Dermatomyositis Rohit Aggarwal, Christina Charles-Schoeman, Joachim Schessl, et al N Engl J Med 2022; 387:1264-1278DOI: 10.1056/NEJMoa2117912 Abstract BACKGROUND Intravenous immune globulin (IVIG) for the treatment of dermatomyositis has not been extensively evaluated. METHODS We conducted a randomized, placebo-controlled trial involving patients with active dermatomyositis. The p...

ORIGINAL ARTICLE Racial and Ethnic Differences in Bystander CPR for Witnessed Cardiac Arrest R. Angel Garcia, John A. Spertus, Saket Girotra, et al N Engl J Med 2022; 387:1569-1578DOI: 10.1056/NEJMoa2200798 Abstract BACKGROUND Differences in the incidence of cardiopulmonary resuscitation (CPR) provided by bystanders contribute to survival disparities among persons with out-of-hospital cardiac arrest. It is critical to understand whether the incidence of ...

ORIGINAL RESEARCH|ARTICLES IN PRESS High-Dose Intravenous Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The IV-HOCSS Trial) Jayshil J. Patel, Rodney Willoughby, Jennifer Peterson, et al Chest Published:September 26, 2022 DOI:https://doi.org/10.1016/j.chest.2022.09.021 Abstract Background Elevated hydrogen sulfide (H2S) contributes to vasodilatat...

DIFFUSE LUNG DISEASE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 4, P815-823, OCTOBER 01, 2022 Predicting Usual Interstitial Pneumonia Histopathology From Chest CT Imaging With Deep Learning Alex Bratt, James M. Williams, Grace Liu, MD  Chest 2022; 162: 815-823 Published: April 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.03.044 Background Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal form of interstitial lung disease (I...

Original Investigation  October 10, 2022 Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021 Global Burden of Disease Long COVID Collaborators JAMA. Published online October 10, 2022. doi:10.1001/jama.2022.18931 Key Points Question  Among individuals who had symptomatic SARS-CoV-2 infection in 2020 and 2021, what prop...

Research Letter  October 19, 2022 Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial Stuart H. Cohen, Thomas J. Louie, Matthew Sims, et al JAMA. Published online October 19, 2022. doi:10.1001/jama.2022.16476 Antibiotics are necessary but often insufficient to treat recurrent Clostridioides difficile infection (rCDI) due to pe...

Original Investigation  October 22, 2022 Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection Christine Johnston, Amalia Magaret, Hyunju Son, et al JAMA. Published online October 22, 2022. doi:10.1001/jama.2022.19061 Key Points Question  What are the rates of viral shedding after first-episode genital herpes simplex virus type 1 (HSV-1) infection? Findings  In this prospective cohort study, 82 partic...