ORIGINAL ARTICLE Early Treatment with Pegylated Interferon Lambda for Covid-19 Gilmar Reis, Eduardo A.S. Moreira Silva, Daniela C. Medeiros Silva, et al N Engl J Med 2023; 388:518-528DOI: 10.1056/NEJMoa2209760 Abstract BACKGROUND The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear. METHODS We conducted a randomized, control...

ARTICLES| VOLUME 11, ISSUE 1, P87-96, JANUARY 01, 2023 Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study Joshua J Solomon, Sonye K Danoff, Felix A Woodhead, et al. Lancet Respir Med 2023; 11: 87-96 Published:September 05, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00260-0 Summary Background Inters...

Research Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study Barak Mizrahi, Tamar Sudry, Natalie Flaks-Manov, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072529 (Published 11 January 2023)Cite this as: BMJ 2023;380:e072529 Abstract Objectives To determine the clinical sequelae of long covid for a year after infection in patients with mild disease and to evaluate its association with age, sex, SARS-CoV-...

ARTICLES| VOLUME 11, ISSUE 1, P45-54, JANUARY 01, 2023 Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial Toby M Maher, Veronica A Tudor, Peter Saunders, et al. Lancet Respir Med 2023; 11: 45-54 Open Access Published: November 11, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00359-...

ARTICLES| VOLUME 5, ISSUE 1, E36-E46, JANUARY 01, 2023 Four SARS-CoV-2 vaccine doses or hybrid immunity in patients on immunosuppressive therapies: a Norwegian cohort study Kristin H Bjørlykke, Hilde S Ørbo, Anne T Tveter, et al. Lancet Rheumatol 2023; 5: E36-E46 Published:November 16, 2022 DOI:https://doi.org/10.1016/S2665-9913(22)00330-7 Summary Background Data on response and safety of repeated vaccinations and hybrid immunity in pat...

ORIGINAL ARTICLE Methylprednisolone for Heart Surgery in Infants — A Randomized, Controlled Trial Kevin D. Hill, Prince J. Kannankeril, Jeffrey P. Jacobs, et al N Engl J Med 2022; 387:2138-2149DOI: 10.1056/NEJMoa2212667 Abstract BACKGROUND Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown. METHODS We conducted a multicen...

CORRESPONDENCE| VOLUME 22, ISSUE 12, P1666-1668, DECEMBER 01, 2022 Resistance of SARS-CoV-2 omicron subvariant BA.4.6 to antibody neutralisation Qian Wang, Zhiteng Li, Jerren Ho, et al Lancet Infect Dis 2022; 22: 1666-1668 SARS-CoV-2, the causative agent of the COVID-19 pandemic, continues to evolve. A subvariant of SARS-CoV-2 omicron (B.1.1.529), known as BA.4.6, emerged in March, 2022, and it appears to be expanding its coverage even in the pr...

Article Published: 15 September 2022 Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus Andreas Mackensen, Fabian Müller, Dimitrios Mougiakakos, et al Nature Medicine volume 28, pages 2124–2132 (2022) Abstract Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized by adaptive immune system activation, formation of double-stranded DNA autoantibodies and organ inflammation. Five patients with ...

SPECIAL ARTICLE The Safety of Inpatient Health Care David W. Bates, David M. Levine, Hojjat Salmasian, et al N Engl J Med 2023; 388:142-153DOI: 10.1056/NEJMsa2206117 Abstract BACKGROUND Adverse events during hospitalization are a major cause of patient harm, as documented in the 1991 Harvard Medical Practice Study. Patient safety has changed substantially in the decades since that study was conducted, and a more current assessment of harm during hospital...

ORIGINAL ARTICLE Hypothermia or Machine Perfusion in Kidney Donors Darren Malinoski, Christina Saunders, Sharon Swain, et al N Engl J Med 2023; 388:418-426DOI: 10.1056/NEJMoa2118265 Abstract BACKGROUND Therapeutic hypothermia in brain-dead organ donors has been shown to reduce delayed graft function in kidney recipients after transplantation. Data are needed on the effect of hypothermia as compared with machine perfusion on outcomes after kidney transpla...