ARTICLES|ONLINE FIRST Past SARS-CoV-2 infection protection against re-infection: a systematic review and meta-analysis COVID-19 Forecasting Team Lancet Published: February 16, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02465-5 Summary Background Understanding the level and characteristics of protection from past SARS-CoV-2 infection against subsequent re-infection, symptomatic COVID-19 disease, and severe disease is essential for predicting future...

REVIEW| VOLUME 10, ISSUE 12, P1178-1188, DECEMBER 01, 2022 Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis Mallikarjuna Ponnapa Reddy, Ashwin Subramaniam, Clara ChuaRyan Ruiyang Ling et al. Lancet Respir Med 2022; 10: 1178-1188 Published:November 03, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00393-9 ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES EditorialIntensive Care Medicine facing the futureCiterio G. OriginalCircular material flow in the intensive care unit—environmental effects and identification of hotspotsHunfeld N. et al. Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort studyRosa R.G. et al. Relationship between immunosuppression and intensive car...

ARTICLES|ONLINE FIRST Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study Jose Villar, Constanza P Soto Conti, Robert B Gunier, et al Lancet Published:January 17, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02467-9 Summary Background In 2021, we showed an increased risk associated with COVID-19 in pregnancy. Since then, the SARS-CoV-2 virus has un...

ORIGINAL ARTICLE Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture Major Extremity Trauma Research Consortium (METRC) N Engl J Med 2023; 388:203-213DOI: 10.1056/NEJMoa2205973 Abstract BACKGROUND Clinical guidelines recommend low-molecular-weight heparin for thromboprophylaxis in patients with fractures, but trials of its effectiveness as compared with aspirin are lacking. METHODS In this pragmatic, multicenter, randomi...

Original Investigation  January 12, 2023 Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial Matthew W. McCarthy, Susanna Naggie, David R. Boulware, et al JAMA. Published online January 12, 2023. doi:10.1001/jama.2022.24100 Key Points Question  Does 50 mg of fluvoxamine twice daily for 10 days, compared with placebo, shorten symptom duration amo...

NEWS 18 January 2023 ChatGPT listed as author on research papers: many scientists disapprove At least four articles credit the AI tool as a co-author, as publishers scramble to regulate its use. Chris Stokel-Walker Nature 613, 620-621 (2023) doi: https://doi.org/10.1038/d41586-023-00107-z The artificial-intelligence chatbot ChatGPT is disrupting many industries, including academia.Credit: Iryna Imago/Shutterstock The artificial-intelligence (AI) ...

Research Letter  January 17, 2023 Timing of Blood Draws Among Patients Hospitalized in a Large Academic Medical Center César Caraballo, Shiwani Mahajan, Karthik Murugiah, et al JAMA. 2023;329(3):255-257. doi:10.1001/jama.2022.21509 Sleep is a key element of patient care and experience, and its deprivation among hospitalized patients is an important stressor that increases their risk of adverse events during and after hospitalization.1-3&...

Original Investigation  Caring for the Critically Ill Patient January 17, 2023 Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial Donna Franklin, Franz E. Babl, Shane George, et al JAMA. 2023;329(3):224-234. doi:10.1001/jama.2022.21805 Key Points Question  Does the early use of nasa...

Original Investigation  January 17, 2023 Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial Robert J. Mentz, Kevin J. Anstrom, Eric L. Eisenstein, et al JAMA. 2023;329(3):214-223. doi:10.1001/jama.2022.23924 Key Points Question  Does torsemide reduce all-cause mortality compared with furosemide in patients with heart fail...