β-Lactam–Resistant Streptococcus pneumoniae Dynamics Following Treatment: A Dose-Response Meta-analysis  Matas Griskaitis,  Luis Furuya-Kanamori,  Kasim Allel,  et al Clinical Infectious Diseases, Volume 75, Issue 11, 1 December 2022, Pages 1962–1970, https://doi.org/10.1093/cid/ciac293 Abstract Background Patient exposure to antibiotics promotes the emergence of drug-resistant pathogens. The aim of this study was to identify whether the temporal dynamics o...

Research Oxygen administration during surgery and postoperative organ injury: observational cohort study David R McIlroy, Matthew S Shotwell, Marcos G Lopez, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-070941 (Published 30 November 2022)Cite this as: BMJ 2022;379:e070941 Abstract Objective To examine whether supraphysiological oxygen administration during surgery is associated with lower or higher postoperative kidney, heart, and lung inj...

Endgames Christmas 2022: Brain Stew Misspelling of antimicrobials by healthcare professionals Daniel Weiand, Joanna Lumb BMJ 2022; 379 doi: https://doi.org/10.1136/bmj.o2946 (Published 19 December 2022)Cite this as: BMJ 2022;379:o2946 Although electronic health records have widely reduced medication errors, and computerised hospital orders are an undeniable step-up in clarity from illegible handwritten orders,1234 they are not a patient safety panace...

Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease Takafumi Kato,  Takanori Asakura,  Caitlin E. Edwards, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1336-1352. doi: 10.1164/rccm.202111-2606OC Abstract Rationale: The incidence and sites of mucus accumulation and molecular regulation of mucin gene expression in coronavirus (COVID-19) lung disease have not been reported. Objectives: To characterize the incidence of mu...

Research Christmas 2022: Physical Quantifying the benefits of inefficient walking: Monty Python inspired laboratory based experimental study Glenn A Gaesser, David C Poole, Siddhartha S Angadi BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072833 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072833 Abstract Objective To compare the rate of energy expenditure of low efficiency walking with high efficiency walking. Design Labo...

Sex Differences in Mortality of ICU Patients According to Diagnosis-related Sex Balance Lucy J. Modra,  Alisa M. Higgins,  David V. Pilcher, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1353-1360. doi: 10.1164/rccm.202203-0539OC. Abstract Rationale: Women have worse outcomes than men in several conditions more common in men, including cardiac surgery and burns. Objectives: To describe the relationship between sex balance within each diagnost...

Research Christmas 2022: Physical Digital disparities among healthcare workers in typing speed between generations, genders, and medical specialties: cross sectional study Alex R Schuurman, M E Baarsma, W Joost Wiersinga, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072784 (Published 19 December 2022)Cite this as: BMJ 2022;379:e072784 Abstract Objective To investigate the typing skills of healthcare professionals. Design Cross...

Research Christmas 2022: Don’t Believe the Hype Everything causes cancer? Beliefs and attitudes towards cancer prevention among anti-vaxxers, flat earthers, and reptilian conspiracists: online cross sectional survey Sonia Paytubi, Yolanda Benavente, Alexandra Montoliu, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072561 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072561 Abstract Objective To evaluate, using an online non-p...

ORIGINAL ARTICLE VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19 Zhujun Cao, Weiyi Gao, Hong Bao, et al N Engl J Med December 28, 2022DOI: 10.1056/NEJMoa2208822 Abstract BACKGROUND Nirmatrelvir–ritonavir has been authorized for emergency use by many countries for the treatment of coronavirus disease 2019 (Covid-19). However, the supply falls short of the global demand, which creates a need for more options. VV116 is an oral antiviral a...

ARTICLES|ONLINE FIRST Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis Alexandre Tran, Shannon M Fernando, Bram Rochwerg, et al. Lancet Respir Med Published:October 10, 2022DOI:https://doi.org/10.1016/S2213-2600(22)00296-X Summary Background Venovenous extracorporeal membrane oxygenation (ECMO) can be considered for patients with COVID-...