ARTICLES|ONLINE FIRST Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial Bhakti K Patel, Krysta S Wolfe, Shruti B Patel, et al Lancet Respir Med Published:January 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00489-1 Summary Background Patients who have received mechanical ventilation can have prolonged cognitive impairment for which there is no known treatment. We aimed to...

ARTICLES|ONLINE FIRST Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial Audrey De Jong, Anne Bignon, François Stephan, et al. Lancet Respir Med Published:January 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00529-X Summary Background Non-invasive ventilation (NIV) and oxygen therapy (high-flow nasal oxygen [HFNO] or standard oxygen)...

ARTICLES|ONLINE FIRST Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial Mickaël Landais, Mai-Anh Nay, Johann Auchabie, et al. Lancet Respir Med Published:January 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00413-1 Summary Background Fasting is frequently imposed before extubation in patients in inte...

ARTICLES|ONLINE FIRST Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study Tài Pham, Leo Heunks, Giacomo Bellani, et al. Lancet Respir Med Published:January 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00449-0 Summary Background Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to ...

Research Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study Jianping Jia, Tan Zhao, Zhaojun Liu, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072691 (Published 25 January 2023)Cite this as: BMJ 2023;380:e072691 Abstract Objective To identify an optimal lifestyle profile to protect against memory loss in older individuals. D...

ARTICLES|ONLINE FIRST Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial Nilufar Mohebbi, Alexander Ritter, Anna Wiegand, et al. Lancet Published:January 25, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02606-X Summary Background Metabolic acidosis is common in kidney transplant recipients and is associated with declining graft functi...

Research Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial Gerhard Pichler, Katharina Goeral, Marlene Hammerl, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072313 (Published 24 January 2023)Cite this as: BMJ 2023;380:e072313 Abstract Objective To investigate whether monitoring of cerebral tissue oxygen s...

Multisystem Inflammatory Syndrome in Adults: Case Finding Through Systematic Review of Electronic Medical Records  Michael Melgar,  Julia Haston,  Jennifer DeCuir,  et al Clinical Infectious Diseases, Volume 75, Issue 11, 1 December 2022, Pages 1903–1911, https://doi.org/10.1093/cid/ciac303 Abstract Background Multisystem inflammatory syndrome in adults (MIS-A) is a severe condition temporally associated with severe acute respiratory syndrome coronavir...

ORIGINAL ARTICLE Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A Annette von Drygalski, Pratima Chowdary, Roshni Kulkarni, et al N Engl J Med 2023; 388:310-318DOI: 10.1056/NEJMoa2209226 Abstract BACKGROUND Efanesoctocog alfa provides high sustained factor VIII activity by overcoming the von Willebrand factor–imposed half-life ceiling. The efficacy, safety, and pharmacokinetics of efanesoctocog alfa for prophylaxis and treatment of bl...

ORIGINAL ARTICLE Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex Hans Pottel, Jonas Björk, Andrew D. Rule, et al N Engl J Med 2023; 388:333-343DOI: 10.1056/NEJMoa2203769 Abstract BACKGROUND The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-base...