ORIGINAL ARTICLE Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network N Engl J Med January 21, 2023DOI: 10.1056/NEJMoa2212663 Abstract BACKGROUND Intravenous fluids and vasopressor agents are commonly used in early resuscitation of patients with sepsis, but comparative data for prioritizing their delivery are l...

Research Impact of community asymptomatic rapid antigen testing on covid-19 related hospital admissions: synthetic control study Xingna Zhang, Ben Barr, Mark Green, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071374 (Published 23 November 2022)Cite this as: BMJ 2022;379:e071374 Abstract Objective To analyse the impact of voluntary rapid testing for SARS-CoV-2 antigen in Liverpool city on covid-19 related hospital admissions. Design&nbs...

ARTICLES| VOLUME 10, ISSUE 12, P1137-1146, DECEMBER 01, 2022 Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial Alexander P J Vlaar, Martin Witzenrath, Pieter van Paassen, et al. Lancet Respir Med 2022; 10: 1137-1146 Published:September 07, 2022 DOI: https://doi.org/10.1016/S2213-2600(22)00297-1 ...

Research Letter  Climate Change and Health December 20, 2022 Association Between the 2021 Heat Wave in Portland, Oregon, and Seattle, Washington, and Emergency Department Visits Amruta Nori-Sarma, Chad Milando, Kate R. Weinberger, et al JAMA. 2022;328(23):2360-2362. doi:10.1001/jama.2022.20665 Heat waves are becoming more frequent and severe, with pronounced effects on human health.1 In late June 2021, temperatures in the US Pacific N...

Original Investigation  Caring for the Critically Ill Patient December 16, 2022 Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial Writing Committee for the REMAP-CAP Investigators JAMA. Published online December 16, 2022. doi:10.1001/jama.2022.23257 Key Points Question  What is the effect of treatment for critically ill patients with COVID-19 on longer-term mortali...

Research Rivaroxaban treatment for six weeks versus three months in patients with symptomatic isolated distal deep vein thrombosis: randomised controlled trial Walter Ageno, Lorenza Bertù, Eugenio Bucherini, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072623 (Published 23 November 2022)Cite this as: BMJ 2022;379:e072623 Abstract Objective To compare two different treatment durations of rivaroxaban in patients with symptomatic isolated di...

Research Global burden of type 2 diabetes in adolescents and young adults, 1990-2019: systematic analysis of the Global Burden of Disease Study 2019 Jinchi Xie, Maoqing Wang, Zhiping Long, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072385 (Published 07 December 2022)Cite this as: BMJ 2022;379:e072385 Abstract Objective To estimate the global burden of type 2 diabetes in adolescents and young adults (aged 15-39 years) from 1990 to 2019. ...

Research Efficacy of awake prone positioning in patients with covid-19 related hypoxemic respiratory failure: systematic review and meta-analysis of randomized trials Jason Weatherald, Ken Kuljit S Parhar, Zainab Al Duhailib, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071966 (Published 07 December 2022)Cite this as: BMJ 2022;379:e071966 Abstract Objective To determine the efficacy and safety of awake prone positioning versus usual care i...

ORIGINAL ARTICLE Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus Tim Hundscheid, Wes Onland, Elisabeth M.W. Kooi, et al N Engl J Med December 6, 2022DOI: 10.1056/NEJMoa2207418 Abstract BACKGROUND Cyclooxygenase inhibitors are commonly used in infants with patent ductus arteriosus (PDA), but the benefit of these drugs is uncertain. METHODS In this multicenter, noninferiority trial, we randomly assigned infants with echocardiogra...

CORRESPONDENCE| VOLUME 23, ISSUE 1, P22-23, JANUARY 01, 2023 Omicron sublineage BQ.1.1 resistance to monoclonal antibodies Prerna Arora, Amy KempfInga, Nehlmeier Sebastian, et al. Lancet Infect Dis Published: November 18, 2022 DOI: https://doi.org/10.1016/S1473-3099(22)00733-2 Vaccination represents the key strategy to control the COVID-19 pandemic through induction of neutralising antibody responses and T cell-associated immunity that subst...