ORIGINAL ARTICLE Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct Xiaochuan Huo, Gaoting Ma, Xu Tong, et al N Engl J Med February 10, 2023DOI: 10.1056/NEJMoa2213379 Abstract BACKGROUND The role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations. METHODS We conducted a multicenter, prospective, open-label, randomized trial in China involving patients wi...

ORIGINAL ARTICLE Evaluation of BNT162b2 Covid-19 Vaccine in Children Younger than 5 Years of Age Flor M. Muñoz, Lawrence D. Sher, Charu Sabharwal, et al N Engl J Med 2023; 388:621-634DOI: 10.1056/NEJMoa2211031 Abstract BACKGROUND Safe and effective vaccines against coronavirus disease 2019 (Covid-19) are urgently needed in young children. METHODS We conducted a phase 1 dose-finding study and are conducting an ongoing phase 2–3 safety, immunogen...

ORIGINAL ARTICLE Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults Ann R. Falsey, Kristi Williams, Efi Gymnopoulou, et al N Engl J Med 2023; 388:609-620DOI: 10.1056/NEJMoa2207566 Abstract BACKGROUND Respiratory syncytial virus (RSV) can cause serious lower respiratory tract disease in older adults, but no licensed RSV vaccine currently exists. An adenovirus serotype 26 RSV vector encoding a prefusion F (preF) protein (Ad26....

ORIGINAL ARTICLE Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults Alberto Papi, Michael G. Ison, Joanne M. Langley, et al N Engl J Med 2023; 388:595-608DOI: 10.1056/NEJMoa2209604 Abstract BACKGROUND Respiratory syncytial virus (RSV) is an important cause of acute respiratory infection, lower respiratory tract disease, clinical complications, and death in older adults. There is currently no licensed vaccine against RSV infection. ...

ORIGINAL ARTICLE Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth Alan T.N. Tita, Waldemar A. Carlo, Elizabeth M. McClure, et al N Engl J Med February 9, 2023DOI: 10.1056/NEJMoa2212111 Abstract BACKGROUND The use of azithromycin reduces maternal infection in women during planned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed on whether an intrapartum oral dose of azithrom...

Original Investigation  February 9, 2023 Effect of Argatroban Plus Intravenous Alteplase vs Intravenous Alteplase Alone on Neurologic Function in Patients With Acute Ischemic Stroke: The ARAIS Randomized Clinical Trial Hui-Sheng Chen, Yu Cui, Zhong-He Zhou, et al JAMA. Published online February 9, 2023. doi:10.1001/jama.2023.0550 Key Points Question  Does argatroban improve neurologic function in patients with acute ischemic stro...

ARTICLES| VOLUME 401, ISSUE 10375, P447-457, FEBRUARY 11, 2023 Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study Jose Villar, Constanza P Soto Conti, Robert B Gunier, et al. Lancet 2023; 401: 447-457 Published:January 17, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02467-9 Summary Background In 2021, we showed an increased risk as...

ARTICLES|ONLINE FIRST Characterisation of SARS-CoV-2 variants in Beijing during 2022: an epidemiological and phylogenetic analysis Yang Pan, Liang Wang, Zhaomin Feng, et al. Lancet Published:February 08, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00129-0 Summary Background Due to the national dynamic zero-COVID strategy in China, there were no persistent local transmissions of SARS-CoV-2 in Beijing before December, 2022. However, imported cases ha...

ORIGINAL ARTICLE Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer Nasser Altorki, Xiaofei Wang, David Kozono, et al N Engl J Med 2023; 388:489-498DOI: 10.1056/NEJMoa2212083 Abstract BACKGROUND The increased detection of small-sized peripheral non–small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy. METHODS We conducted a multicenter, noninferiority, phase 3 trial in which...

Original Investigation  January 26, 2023 Household Transmission of Influenza A Viruses in 2021-2022 Melissa A. Rolfes, H. Keipp Talbot, Huong Q. McLean, et al JAMA. Published online January 26, 2023. doi:10.1001/jama.2023.0064 Key Points Question  What is the risk of influenza A(H3N2) virus infection among household contacts of patients diagnosed with influenza during the 2021-2022 season compared with influenza seasons before th...