Original Investigation  May 1, 2023 Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis: The EXIT-SEP Randomized Clinical Trial Songqiao Liu, Chen Yao, Jianfeng Xie, et al JAMA Intern Med. Published online May 1, 2023. doi:10.1001/jamainternmed.2023.0780 Key Points Question  Is Xuebijing injection (XBJ) effective in reducing mortality in patients with sepsis? Findings  In this randomized c...

Research Letter  Physician Work Environment and Well-Being February 6, 2023 Excess Mortality Among US Physicians During the COVID-19 Pandemic Mathew V. Kiang, Lindsey E. Carlasare, Sonoo Thadaney Israni, et al JAMA Intern Med. 2023;183(4):374-376. doi:10.1001/jamainternmed.2022.6308 In the US, the COVID-19 pandemic has already resulted in over 1 million excess deaths,1 defined as the difference between the num...

Original Investigation  March 27, 2023 Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock Nicholas A. Bosch, Bijan Teja, Anica C. Law, et al JAMA Intern Med. 2023;183(5):451-459. doi:10.1001/jamainternmed.2023.0258 Key Points Question  What is the comparative effectiveness of fludrocortisone added to hydrocortisone vs hydrocortisone alone among patients with septic shock...

Research Letter  March 30, 2023 Comparison of Availability of Trial Results in ClinicalTrials.gov and PubMed by Data Source and Funder Type Julianne T. Nelson, Tony Tse, Yvonne Puplampu-Dove, et al JAMA. Published online March 30, 2023. doi:10.1001/jama.2023.2351 Timely dissemination of clinical trial results is essential for improving transparency and ensuring that findings are available to inform evidence-based medicine.1 Prior analyse...

Original Investigation  February 20, 2023 Prevalence of Chronic Kidney Disease in China: Results From the Sixth China Chronic Disease and Risk Factor Surveillance Limin Wang, Xin Xu, Mei Zhang, et al JAMA Intern Med. Published online February 20, 2023. doi:10.1001/jamainternmed.2022.6817 Key Points Question  What is the prevalence of chronic kidney disease (CKD) in China? Findings  In this nationally representative c...

Original Investigation  Caring for the Critically Ill Patient March 21, 2023 Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19 Ewan C. Goligher, Patrick R. Lawler, Thomas P. Jensen, et al JAMA. 2023;329(13):1066-1077. doi:10.1001/jama.2023.3651 Key Points Question  What patient characteristics are associated with benefit or harm of therapeutic-dose heparin in patients hospitalized for mode...

Original Investigation  April 4, 2023 Differences in Treatment Patterns and Outcomes of Acute Myocardial Infarction for Low- and High-Income Patients in 6 Countries Bruce E. Landon, Laura A. Hatfield, Pieter Bakx, et al JAMA. 2023;329(13):1088-1097. doi:10.1001/jama.2023.1699 Key Points Question  How do treatment patterns and outcomes for older patients presenting with acute myocardial infarction differ for low- vs high-income in...

CORRESPONDENCE Stroke, Myocardial Infarction, and Pulmonary Embolism after Bivalent Booster Marie-Joelle Jabagi, Marion Bertrand, Jérémie Botton, et al N Engl J Med March 29, 2023DOI: 10.1056/NEJMc2302134 TO THE EDITOR: A bivalent messenger RNA vaccine targeting both the ancestral and omicron BA.4–BA.5 sublineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Pfizer–BioNTech) was introduced in France in early October 2022 and recommended ...

SPECIAL ARTICLE Air Pollution and Mortality at the Intersection of Race and Social Class Kevin P. Josey, Scott W. Delaney, Xiao Wu, et al N Engl J Med March 24, 2023DOI: 10.1056/NEJMsa2300523 Abstract BACKGROUND Black Americans are exposed to higher annual levels of air pollution containing fine particulate matter (particles with an aerodynamic diameter of ≤2.5 μm [PM2.5]) than White Americans and may be more susceptible to its health effects. Low-income...

ORIGINAL ARTICLE Transcatheter Arterialization of Deep Veins in Chronic Limb-Threatening Ischemia Mehdi H. Shishehbor, Richard J. Powell, Miguel F. Montero-Baker, et al N Engl J Med 2023; 388:1171-1180DOI: 10.1056/NEJMoa2212754 Abstract BACKGROUND Approximately 20% of patients with chronic limb-threatening ischemia have no revascularization options, leading to above-ankle amputation. Transcatheter arterialization of the deep veins is a percutaneous appro...