Original Investigation  February 21, 2023 History of Low Hourly Wage and All-Cause Mortality Among Middle-aged Workers Katrina L. Kezios, Peiyi Lu, Sebastian Calonico, et al JAMA. 2023;329(7):561-573. doi:10.1001/jama.2023.0367 Key Points Question  Is a history of sustained low-wage earning during peak midlife earning years associated with elevated mortality risk and excess mortality? Findings  In a longitudinal stud...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalEffectiveness of an intensive care telehealth programme to improve process quality (ERIC): a multicentre stepped wedge cluster randomised controlled trialSpeis C.D. et al. OriginalsEpidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unitGaillet A., Bay P. and Groh M. Renal outcomes following intravenous contrast administration in patients with...

Original Investigation  February 21, 2023 Aspirin Discontinuation at 24 to 28 Weeks’ Gestation in Pregnancies at High Risk of Preterm Preeclampsia: A Randomized Clinical Trial Manel Mendoza, Erika Bonacina, Pablo Garcia-Manau, et al JAMA. 2023;329(7):542-550. doi:10.1001/jama.2023.0691 Key Points Question  Among individuals taking aspirin to prevent preterm preeclampsia, can aspirin be discontinued at 24 to 28 weeks of gestation ...

Research Health and nutrition claims for infant formula: international cross sectional survey Ka Yan Cheung, Loukia Petrou, Bartosz Helfer, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-071075 (Published 15 February 2023)Cite this as: BMJ 2023;380:e071075 Abstract Objectives To review available health and nutrition claims for infant formula products in multiple countries and to evaluate the validity o...

Original Published: 10 February 2023 Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study Alexis Tabah, Niccolò Buetti, Quentin Staiquly, et al Intensive Care Med (2023). https://doi.org/10.1007/s00134-022-06944-2 Abstract Purpose In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular ...

Original Investigation  Less Is More September 19, 2022 Perioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery Chan Mi Park, Sharon K. Inouye, Edward R. Marcantonio, et al JAMA Intern Med. 2022;182(11):1117-1127. doi:10.1001/jamainternmed.2022.3680 Key Points Question  Is perioperative gabapentin use associated with in-hospital adverse clinical events among older adults after maj...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalLong-term outcomes of patients with COVID-19 treated with helmet noninvasive ventilation or usual respiratory support: follow-up study of the Helmet-COVID randomized clinical trialArabi Y.M. et al. Excess mortality among non-COVID-19 surgical patients attributable to the exposure of French intensive and intermediate care units to the pandemicDuclos A. et al. What's New in Intensive CareNeuromonitoring for prog...

ORIGINAL ARTICLE Trial of Endovascular Thrombectomy for Large Ischemic Strokes Amrou Sarraj, Ameer E. Hassan, Michael G. Abraham, et al N Engl J Med February 10, 2023DOI: 10.1056/NEJMoa2214403 Abstract BACKGROUND Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations. METHODS We performed a prospective, randomized, open-label, adaptive, international trial ...

ORIGINAL ARTICLE Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct Xiaochuan Huo, Gaoting Ma, Xu Tong, et al N Engl J Med February 10, 2023DOI: 10.1056/NEJMoa2213379 Abstract BACKGROUND The role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations. METHODS We conducted a multicenter, prospective, open-label, randomized trial in China involving patients wi...

ORIGINAL ARTICLE Evaluation of BNT162b2 Covid-19 Vaccine in Children Younger than 5 Years of Age Flor M. Muñoz, Lawrence D. Sher, Charu Sabharwal, et al N Engl J Med 2023; 388:621-634DOI: 10.1056/NEJMoa2211031 Abstract BACKGROUND Safe and effective vaccines against coronavirus disease 2019 (Covid-19) are urgently needed in young children. METHODS We conducted a phase 1 dose-finding study and are conducting an ongoing phase 2–3 safety, immunogen...