ORIGINAL ARTICLE Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia Floor L.F. van Baarle, Emma K. van de Weerdt, Walter J.F.M. van der Velden, et al N Engl J Med 2023; 388:1956-1965DOI: 10.1056/NEJMoa2214322 Abstract BACKGROUND Transfusion guidelines regarding platelet-count thresholds before the placement of a central venous catheter (CVC) offer conflicting recommendations because of a lack of good-quality evidence. The routine...

ARTICLES|ONLINE FIRST Measuring the global response to antimicrobial resistance, 2020–21: a systematic governance analysis of 114 countries Jay Patel, Anne Harant, Genevie Fernandes, et al Lancet Infect Dis Published:January 16, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00796-4 Summary Background Understanding strategic commitments and policy responses to overcome antimicrobial resistance at the national, regional, and global levels is required t...

ARTICLES|ONLINE FIRST Incidence of infection with multidrug-resistant Gram-negative bacteria and vancomycin-resistant enterococci in carriers: a systematic review and meta-regression analysis Roel P J Willems, Karin van Dijk, Maria J G T Vehreschild, et al Lancet Infect Dis Published:January 30, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00811-8 Summary Background Carriers of multidrug-resistant bacteria are at risk of infections with these bacter...

ARTICLES|ONLINE FIRST Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalised with COVID-19 (COVASP): a pragmatic, cluster-randomised, non-inferiority trial Justin Z Chen, Holly L Hoang, Maryna Yaskina, et al Lancet Infect Dis Published:January 27, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00832-5 Summary Background The COVID-19 pandemic has been associated with increased antimicrobial use despite ...

ARTICLES|ONLINE FIRST Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study Martin Hoenigl, Jon Salmanton-García, Matthias Egger, et al Lancet Infect Dis Published:February 15, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00872-6 Summary Background The European Confederation of Medical Mycology (ECMM) collected data on epidemiology, risk ...

ARTICLES|ONLINE FIRST Prevention of non-ventilator-associated hospital-acquired pneumonia in Switzerland: a type 2 hybrid effectiveness–implementation trial Aline Wolfensberger, Lauren Clack, Stefanie von Felten, et al Lancet Infect Dis Published:March 06, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00812-X Summary Background Non-ventilator-associated hospital-acquired pneumonia (nvHAP) is a frequent, but under-researched infection. We aimed to sim...

ARTICLES|ONLINE FIRST Performance of antigen lateral flow devices in the UK during the alpha, delta, and omicron waves of the SARS-CoV-2 pandemic: a diagnostic and observational study David W Eyre, Matthias Futschik, Sarah Tunkel, et al Lancet Infect Dis Published:March 28, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00129-9 Summary Background Antigen lateral flow devices (LFDs) have been widely used to control SARS-CoV-2. We aimed to improve under...

ARTICLES| VOLUME 23, ISSUE 5, P589-597, MAY 2023 Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study Douglas L Fink, Helen Callaby, Akish Luintel, et al. Lancet Infect Dis 2023; 23: 589-597 Published:December 22, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00806-4 Summary Background The scale of the 2022 global mpox (formerly know...

ARTICLES| VOLUME 23, ISSUE 5, P556-567, MAY 2023 Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression Niklas Bobrovitz, Harriet Ware, Xiaomeng Ma, et al. Lancet Infect Dis 2023; 23: 556-567 Published:January 18, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00801-5 Summary Background The global surge in the omicron (B.1.1.529) variant has ...

Research Nirmatrelvir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records Yan Xie, Benjamin Bowe, Ziyad Al-Aly BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-073312 (Published 11 April 2023)Cite this as: BMJ 2023;381:e073312 Abstract Objective To estimate the effectiveness of nirmatrelvir, compared with no treatment, in reducing admission to hospital or death at 30...