Research Molnupiravir and risk of post-acute sequelae of covid-19: cohort study Yan Xie, Taeyoung Choi, Ziyad Al-Aly BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-074572 (Published 25 April 2023)Cite this as: BMJ 2023;381:e074572 Abstract Objective To examine whether treatment with the antiviral agent molnupiravir during the first five days of SARS-CoV-2 infection is associated with reduced risk of post-acute adverse health outcomes. Design&nb...

Research Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial Peter S Blair, Grace Young, Clare Clement, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-072488 (Published 26 April 2023)Cite this as: BMJ 2023;381:e072488 Abstract Objective To assess whether an easy-to-use multifaceted interv...

Original Investigation  April 28, 2023 Comparing Physician and Artificial Intelligence Chatbot Responses to Patient Questions Posted to a Public Social Media Forum John W. Ayers, Adam Poliak, Mark Dredze, et al JAMA Intern Med. Published online April 28, 2023. doi:10.1001/jamainternmed.2023.1838 Key Points Question  Can an artificial intelligence chatbot assistant, provide responses to patient questions that are of comparable qua...

ARTICLES|ONLINE FIRST Effectiveness of handwashing with soap for preventing acute respiratory infections in low-income and middle-income countries: a systematic review and meta-analysis Ian Ross, Sarah Bick, Philip Ayieko, et al Lancet Published:April 27, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00021-1 Summary Background Acute respiratory infection (ARI) is a leading cause of morbidity and mortality globally, with 83% of ARI mortality occurring...

ARTICLES|ONLINE FIRST Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study Jesús F Bermejo-Martin, Nadia García-Mateo, Anna Motos, et al Lancet Microbe Published:April 25, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00041-1 Summary Background The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations be...

ORIGINAL ARTICLE Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma Peter J. Hutchinson, Hadie Adams, Midhun Mohan, et al N Engl J Med April 23, 2023DOI: 10.1056/NEJMoa2214172 Abstract BACKGROUND Traumatic acute subdural hematomas frequently warrant surgical evacuation by means of a craniotomy (bone flap replaced) or decompressive craniectomy (bone flap not replaced). Craniectomy may prevent intracranial hypertension, but whether it ...

ORIGINAL ARTICLE Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers Laure F. Pittet, Nicole L. Messina, Francesca Orsini, et al N Engl J Med 2023; 388:1582-1596DOI: 10.1056/NEJMoa2212616 Abstract BACKGROUND The bacille Calmette–Guérin (BCG) vaccine has immunomodulatory “off-target” effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19). METHODS In this international, double-blind, ...

Original Investigation  April 20, 2023 Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial Michael I. D’Angelica, Ryan J. Ellis, Jason B. Liu, et al JAMA. Published online April 20, 2023. doi:10.1001/jama.2023.5728 Key Points Question  Does use of perioperative broad-spectrum antibiotics reduce postoperative surgical site infection after open pancreat...

ARTICLES|ONLINE FIRST Intravenous ravulizumab in mechanically ventilated patients hospitalised with severe COVID-19: a phase 3, multicentre, open-label, randomised controlled trial Djillali Annane, Sean J Pittock, Hrishikesh S Kulkarni, et al Lancet Respir Med Published:March 20, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00082-6 Summary Background The complement pathway is a potential target for the treatment of severe COVID-19. We evaluated the ...

ARTICLES|ONLINE FIRST Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3) Jean Reignier, Gaetan Plantefeve, Jean-Paul Mira, et al Lancet Respir Med Published:March 20, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00092-9 Summary Background The optimal calorie and protein intakes at the acute phase of severe critical illness remain unknow...