Research Comparison of mental health symptoms before and during the covid-19 pandemic: evidence from a systematic review and meta-analysis of 134 cohorts Ying Sun, Yin Wu, Suiqiong Fan, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-074224 (Published 08 March 2023)Cite this as: BMJ 2023;380:e074224 Abstract Objective To synthesise results of mental health outcomes in cohorts before and during the covid-19 pandemic. Design Systematic ...

Research Molnupiravir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records Yan Xie, Benjamin Bowe, Ziyad Al-Aly BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072705 (Published 07 March 2023)Cite this as: BMJ 2023;380:e072705 Abstract Objective To emulate a randomized target trial to estimate the association between the antiviral drug molnupiravir and hospital admis...

ARTICLES|ONLINE FIRST Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study James Peter Allinson, Nishi Chaturvedi, Andrew Wong, et al. Lancet Published:March 07, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00131-9 Summary Background Lower respiratory tract infections (LRTIs) in early childhood are known to influence lung development and lifelong lung hea...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalDaily point-of-care ultrasound-assessment of central venous catheter-related thrombosis in critically ill patients: a prospective multicenter studyWu C. et al. OPEN ACCESSOptimal oxygen and mean arterial blood pressure targets after cardiac arrestSkrifvars M., Bray J. and Hassager C. Understanding the DiseaseHigh-risk pulmonary embolism in the intensive care unitHelms J., Carrier M. and Klok F.A. Recent adv...

ORIGINAL ARTICLE Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, et al N Engl J Med March 6, 2023DOI: 10.1056/NEJMoa2213558 Abstract BACKGROUND Pulmonary arterial hypertension is a progressive disease involving proliferative remodeling of the pulmonary vessels. Despite therapeutic advances, the disease-associated morbidity and mortality remain high. Sotatercept is a ...

Original Investigation  March 7, 2023 Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death: A Randomized Clinical Trial Anna Roca, Bully Camara, Joel D. Bognini, et al JAMA. 2023;329(9):716-724. doi:10.1001/jama.2022.24388 Key Points Question  Does azithromycin administered orally during labor reduce neonatal sepsis and mortality? Findings  This randomized trial in West Africa included 11 983 bi...

Research Inequities in surgical outcomes by race and sex in the United States: retrospective cohort study Dan P Ly, Mariah B Blegen, Melinda M Gibbons, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-073290 (Published 01 March 2023)Cite this as: BMJ 2023;380:e073290 Abstract Objective To assess inequities in mortality by race and sex for eight common surgical procedures (elective and non-elective) across specialties in the United States. D...

ARTICLES|ONLINE FIRST Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study Samuel Channon-Wells, Ortensia Vito, Andrew J McArdle, et al. Lancet Rheumatol Published:February 14, 2023 DOI:https://doi.org/10.1016/S2665-9913(23)00029-2 Summary Background Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infe...

ARTICLES|ONLINE FIRST Long-term effectiveness of COVID-19 vaccines against infections, hospitalisations, and mortality in adults: findings from a rapid living systematic evidence synthesis and meta-analysis up to December, 2022 Nana Wu, Keven Joyal-Desmarais, Paula A B Ribeiro, et al. Lancet Respir Med Published: February 10, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00015-2 Summary Background Synthesising evidence on the long-term vaccine effect...

ARTICLES|ONLINE FIRST Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials Alain Amstutz, Benjamin Speich, France Mentré, et al. Lancet Respir Med Published:February 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00528-8 Summary Background Interpretation of the evidence from randomised controlled trials (RCTs) of remdesivir in patients treated in...