Original Investigation  July 10, 2023 Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial Jane A. O’Halloran, Emily R. Ko, Kevin J. Anstrom, et al JAMA. Published online July 10, 2023. doi:10.1001/jama.2023.11043 Key Points Question  Do abatacept, cenicriviroc, or infliximab improve time to recovery for patients hospitalized with COVID-19 pneumonia compa...

ARTICLES|ONLINE FIRST Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial Samuel M Brown, Christina E Barkauskas, Birgit Grund, et al Lancet Respir Med Published:June 19, 2023DOI:https://doi.org/10.1016/S2213-2600(23)00147-9 Summary Background There is a clinical need for therapeutics for COVID-19 patients with acute hypoxemic respiratory fail...

Original Open Access Published: 13 May 2023 Acute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial Xiang Wu, Li Xie, Jin Lei, et al Intensive Care Medicine volume 49, pages 633–644 (2023) Abstract Purpose Severe traumatic brain injury (TBI) leads to acute coma and may result in prolonged disorder of consciousness (pDOC). We aimed to determine whether right median nerve e...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalsGiving a voice to patients at high risk of dying in the intensive care unit: a multiple source approachGrasselli G. et al. OPEN ACCESS ~ OriginalSepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational studyWhite K.C. et al. OPEN ACCESSMachine learning to predict poor school perfor...

Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock Maj‐Brit Nørregaard Kjær, Tine Sylvest Meyhoff, Praleene Sivapalan, et al Intensive Care Med 2023 Jun 18. doi: 10.1007/s00134-023-07114-8. Online ahead of print Abstract Purpose: To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conserva...

Direct assessment of microcirculation in shock: a randomized-controlled multicenter study Raphael Romano Bruno, Jakob Wollborn, Karl Fengler, et al Intensive Care Medicine volume 49, pages 645–655 (2023) Abstract Purpose Shock is a life-threatening condition characterized by substantial alterations in the microcirculation. This study tests the hypothesis that considering sublingual microcirculatory perfusion variables in the therapeutic management reduces 3...

ARTICLES| VOLUME 5, ISSUE 6, E370-E379, JUNE 2023 Identifying subtypes of heart failure from three electronic health record sources with machine learning: an external, prognostic, and genetic validation study Amitava Banerjee, Ashkan Dashtban, Suliang Chen, et al. Lancet Digit Health Published: June, 2023 DOI:https://doi.org/10.1016/S2589-7500(23)00065-1 Summary Background Machine learning has been used to analyse heart failure subtypes...

Research Therapeutic value of first versus supplemental indications of drugs in US and Europe (2011-20): retrospective cohort study Kerstin N Vokinger, Camille E G Glaus, Aaron S Kesselheim, et al BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2022-074166 (Published 05 July 2023)Cite this as: BMJ 2023;382:e074166 Abstract Objective To analyze the therapeutic value of supplemental indications compared with first indications for drugs approved in the US ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ Conference Reports and Expert PanelESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategiesGrasselli G. et al. OPEN ACCESS ~ OriginalDirect assessment of microcirculation in shock: a randomized-controlled multicenter studyBruno R.R. et al.  OriginalRelationship between COVID-19 and ICU-acquired colonization and infection related to mult...

Original Investigation  July 10, 2023 A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria Valerie M. Vaughn, Ashwin Gupta, Lindsay A. Petty, et al JAMA Intern Med. Published online July 10, 2023. doi:10.1001/jamainternmed.2023.2749 Key Points Question  Is stewardship focused on diagnostic testing or antibiotic treatment associated with reduced asymptomatic bacteriuria (ASB) treatm...