ORIGINAL ARTICLE Effect of Donor Sex on Recipient Mortality in Transfusion Michaël Chassé, Dean A. Fergusson, Alan Tinmouth, et al N Engl J Med 2023; 388:1386-1395DOI: 10.1056/NEJMoa2211523 Abstract BACKGROUND Conflicting observational evidence exists regarding the association between the sex of red-cell donors and mortality among transfusion recipients. Evidence to inform transfusion practice and policy is limited. METHODS In this multicenter, dou...

Research Letter  April 6, 2023 Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in Fall-Winter 2022-2023 Yan Xie, Taeyoung Choi, Ziyad Al-Aly JAMA. Published online April 6, 2023. doi:10.1001/jama.2023.5348 In the first year of the COVID-19 pandemic, 2 US studies suggested that people hospitalized for COVID-19 had nearly 5 times the risk of 30-day mortality compared with those hospitalized for seasonal influenza.1,2&n...

Research Letter  April 3, 2023 Sharing of Individual Patient-Level Data by Trialists of Randomized Clinical Trials of Pharmacological Treatments for COVID-19 Laura C. Esmail, Philipp Kapp, Rouba Assi, et al JAMA. Published online April 3, 2023. doi:10.1001/jama.2023.4590 Access to individual patient-level data (IPD) of randomized clinical trials (RCTs) increases the reproducibility of research, facilitates exploration of effect modifiers, and leve...

Original Investigation  Caring for the Critically Ill Patient April 11, 2023 Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial Writing Committee for the REMAP-CAP Investigators JAMA. 2023;329(14):1183-1196. doi:10.1001/jama.2023.4480 Key Points Question  Does initiating an angiotensin-conve...

Original Investigation  April 11, 2023 Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor–Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials Wesley H. Self, Matthew S. Shotwell, Kevin W. Gibbs, et al JAMA. 2023;329(14):1170-1182. doi:10.1001/jama.2023.3546 Key Points Question  Among adults hospitalized with severe COVID-19, does treatment with synthetic angio...

ORIGINAL ARTICLE Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery Luis D. Pacheco, Rebecca G. Clifton, George R. Saade, et al N Engl J Med 2023; 388:1365-1375DOI: 10.1056/NEJMoa2207419 Abstract BACKGROUND Prophylactic use of tranexamic acid at the time of cesarean delivery has been shown to decrease the calculated blood loss, but the effect on the need for blood transfusions is unclear. METHODS We randomly assigned patients...

Original Investigation  April 11, 2023 Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial Johan Sundström, Lars Lind, Shamim Nowrouzi, et al JAMA. 2023;329(14):1160-1169. doi:10.1001/jama.2023.3322 Key Points Question  Is there a potential for personalized drug therapy in hypertension, and, if so, what is the magnitude of the benefit of personalization? Findings  In this...

ARTICLES| VOLUME 4, ISSUE 5, E330-E339, MAY 2023 Infection and co-infection patterns of community-acquired pneumonia in patients of different ages in China from 2009 to 2020: a national surveillance study Yan-Ning Liu, Yun-Fa Zhang, Qiang Xu, et al Lancet Microbe 2023; 4: E330-E339 Published:March 28, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00031-9 Summary Background Severe community-acquired pneumonia (SCAP) is associated with ...

Original Investigation  May 1, 2023 Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis: The EXIT-SEP Randomized Clinical Trial Songqiao Liu, Chen Yao, Jianfeng Xie, et al JAMA Intern Med. Published online May 1, 2023. doi:10.1001/jamainternmed.2023.0780 Key Points Question  Is Xuebijing injection (XBJ) effective in reducing mortality in patients with sepsis? Findings  In this randomized c...

Research Letter  Physician Work Environment and Well-Being February 6, 2023 Excess Mortality Among US Physicians During the COVID-19 Pandemic Mathew V. Kiang, Lindsey E. Carlasare, Sonoo Thadaney Israni, et al JAMA Intern Med. 2023;183(4):374-376. doi:10.1001/jamainternmed.2022.6308 In the US, the COVID-19 pandemic has already resulted in over 1 million excess deaths,1 defined as the difference between the num...