Research Therapeutic value of first versus supplemental indications of drugs in US and Europe (2011-20): retrospective cohort study Kerstin N Vokinger, Camille E G Glaus, Aaron S Kesselheim, et al BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2022-074166 (Published 05 July 2023)Cite this as: BMJ 2023;382:e074166 Abstract Objective To analyze the therapeutic value of supplemental indications compared with first indications for drugs approved in the US ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ Conference Reports and Expert PanelESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategiesGrasselli G. et al. OPEN ACCESS ~ OriginalDirect assessment of microcirculation in shock: a randomized-controlled multicenter studyBruno R.R. et al.  OriginalRelationship between COVID-19 and ICU-acquired colonization and infection related to mult...

Original Investigation  July 10, 2023 A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria Valerie M. Vaughn, Ashwin Gupta, Lindsay A. Petty, et al JAMA Intern Med. Published online July 10, 2023. doi:10.1001/jamainternmed.2023.2749 Key Points Question  Is stewardship focused on diagnostic testing or antibiotic treatment associated with reduced asymptomatic bacteriuria (ASB) treatm...

Original Investigation  July 10, 2023 Temporal Clustering of Critical Illness Events on Medical Wards Samik Doshi, Saeha Shin, Lauren Lapointe-Shaw, et al JAMA Intern Med. Published online July 10, 2023. doi:10.1001/jamainternmed.2023.2629 Key Points Question  Is a critical illness event (death or intensive care unit transfer) associated with an increase in the near-term risk of critical illness in other patients on the same medi...

Original Investigation  June 26, 2023 Evidence for Anchoring Bias During Physician Decision-Making Dan P. Ly, Paul G. Shekelle, Zirui Song JAMA Intern Med. Published online June 26, 2023. doi:10.1001/jamainternmed.2023.2366 Key Points Question  Do emergency department physicians anchor on information found in the patient visit reason section documented before a physician sees the patient? Findings  In this cross-sect...

Original Investigation  June 26, 2023 Use of Mechanical Ventilation Across 3 Countries Naheed K. Jivraj, Andrea D. Hill, Meng-Shiou Shieh, et al JAMA Intern Med. Published online June 26, 2023. doi:10.1001/jamainternmed.2023.2371 Key Points Question  Do population-level rates of invasive mechanical ventilation differ among countries? Findings  In this cohort study of 59 873 hospital admissions in England, 70 250 in C...

Original Investigation  January 18, 2023 Association of Whole Blood With Survival Among Patients Presenting With Severe Hemorrhage in US and Canadian Adult Civilian Trauma Centers Crisanto M. Torres, Alistair Kent, Dane Scantling, et al JAMA Surg. 2023;158(5):532-540. doi:10.1001/jamasurg.2022.6978 Key Points Question  Is whole blood as an adjunct to component therapy–based massive transfusion protocol (MTP) compared with MTP alone associa...

Original Investigation  February 27, 2023 Performance on Patient Experience Measures of Former Chief Medical Residents as Physician Exemplars Chosen by the Profession Lucy Chen, J. Michael McWilliams JAMA Intern Med. 2023;183(4):350-359. doi:10.1001/jamainternmed.2023.0025 Key Points Question  What can be learned about the medical profession’s ability to identify physician exemplars using the selection of chief medical residents and their ...

Original Investigation  June 6, 2023 Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial Ajit P. Limaye, Klemens Budde, Atul Humar, et al JAMA. 2023;330(1):33-42. doi:10.1001/jama.2023.9106 Key Points Question  Is prophylaxis with letermovir noninferior to valganiclovir for cytomegalovirus (CMV) disease prevention in high-risk CMV-seronegative kidney transpl...

Research Association between surgeon volume and patient outcomes after elective shoulder replacement surgery using data from the National Joint Registry and Hospital Episode Statistics for England: population based cohort study Epaminondas Markos Valsamis, Gary S Collins, Rafael Pinedo-Villanueva, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2023-075355 (Published 21 June 2023)Cite this as: BMJ 2023;381:e075355 Abstract Objective To investigate...