Original Investigation  May 21, 2023 Airway-Occluding Mucus Plugs and Mortality in Patients With Chronic Obstructive Pulmonary Disease Alejandro A. Diaz, José L. Orejas, Scott Grumley, et al JAMA. Published online May 21, 2023. doi:10.1001/jama.2023.2065 Key Points Question  Are mucus plugs that occlude airways identified on computed tomography scans in patients with chronic obstructive pulmonary disease (COPD) associated with in...

Research Women and non-white people among Lasker Award recipients from 1946 to 2022: cross sectional study Jeremy W Jacobs, Lorin A Bibb, Elizabeth S Allen, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2023-074968 (Published 17 May 2023)Cite this as: BMJ 2023;381:e074968 Abstract Objective To determine whether gender and racial inequities exist among Lasker Award recipients. Design Observational, cross sectional analysis. Setting&nbs...

ORIGINAL ARTICLE Single-Dose Rifapentine in Household Contacts of Patients with Leprosy Le Wang, Hongsheng Wang, Liangbin Yan, et al N Engl J Med 2023; 388:1843-1852DOI: 10.1056/NEJMoa2205487 Abstract BACKGROUND Previous studies have suggested that a single dose of rifampin has protective effects against leprosy in close contacts of patients with the disease. Rifapentine was shown to have greater bactericidal activity against Mycobacterium leprae than ri...

ORIGINAL ARTICLE Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage Ioannis Gallos, Adam Devall, James Martin, et al N Engl J Med May 9, 2023DOI: 10.1056/NEJMoa2303966 Abstract BACKGROUND Delays in the detection or treatment of postpartum hemorrhage can result in complications or death. A blood-collection drape can help provide objective, accurate, and early diagnosis of postpartum hemorrhage, and delayed or inconsistent use of ef...

ORIGINAL ARTICLE A Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis Jay Tuttle, Edit Drescher, Jesus Abraham Simón-Campos, et al N Engl J Med 2023; 388:1853-1862DOI: 10.1056/NEJMoa2209856 Abstract BACKGROUND Peresolimab is a humanized IgG1 monoclonal antibody designed to stimulate the endogenous programmed cell death protein 1 (PD-1) inhibitory pathway. Stimulation of this pathway would be a novel approach to the treatment of patients wi...

ORIGINAL ARTICLE Transcatheter Repair for Patients with Tricuspid Regurgitation Paul Sorajja, Brian Whisenant, Nadira Hamid, et al N Engl J Med 2023; 388:1833-1842DOI: 10.1056/NEJMoa2300525 Abstract BACKGROUND Severe tricuspid regurgitation is a debilitating condition that is associated with substantial morbidity and often with poor quality of life. Decreasing tricuspid regurgitation may reduce symptoms and improve clinical outcomes in patients with this...

Original Investigation  May 25, 2023 Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, et al JAMA. Published online May 25, 2023. doi:10.1001/jama.2023.8823 Key Points Question  What symptoms are differentially present in SARS-CoV-2–infected individuals 6 months or more after infection compared with uninfected individuals, and what symptom-based c...

Original Investigation  April 20, 2023 Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial Michael I. D’Angelica, Ryan J. Ellis, Jason B. Liu, et al JAMA. 2023;329(18):1579-1588. doi:10.1001/jama.2023.5728 Key Points Question  Does use of perioperative broad-spectrum antibiotics reduce postoperative surgical site infection after open pancreatoduodenec...

Original Investigation  May 9, 2023 Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis: A Randomized Clinical Trial Alexandre Louvet, Julien Labreuche, Thong Dao, et al JAMA. 2023;329(18):1558-1566. doi:10.1001/jama.2023.4902 Key Points Question  Among patients with severe alcohol-related hepatitis, does the combination of amoxicillin-clavulanate with prednisolon...

Original Investigation  May 1, 2023 Effects of a Multimodal Transitional Care Intervention in Patients at High Risk of Readmission: The TARGET-READ Randomized Clinical Trial Jacques Donzé, Gregor John, Daniel Genné, et al JAMA Intern Med. Published online May 1, 2023. doi:10.1001/jamainternmed.2023.0791 Key Points Question  Could a transitional care intervention targeting higher-risk medical patients reduce the risk of 30-day unp...