Editorial  June 16, 2023 Do Prolonged Infusions of β-Lactam Antibiotics Improve Outcomes in Critically Ill Patients With Sepsis? Claire N. Shappell, Michael Klompas, Chanu Rhee JAMA. Published online June 16, 2023. doi:10.1001/jama.2023.6483 There has been a concerted effort over the past 2 decades to improve sepsis outcomes by enhancing recognition of sepsis and decreasing the time to administration of appropriate antibiotics.1 Sepsis m...

ORIGINAL ARTICLE Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults Matthew E. Prekker, Brian E. Driver, Stacy A. Trent, et al N Engl J Med June 16, 2023DOI: 10.1056/NEJMoa2301601 Abstract BACKGROUND Whether video laryngoscopy as compared with direct laryngoscopy increases the likelihood of successful tracheal intubation on the first attempt among critically ill adults is uncertain. METHODS In a multicenter, randomize...

Original Investigation  Caring for the Critically Ill Patient June 16, 2023 Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial Giacomo Monti, Nikola Bradić, Matteo Marzaroli, et al JAMA. Published online June 16, 2023. doi:10.1001/jama.2023.10598 Key Points Question  Does continuous administration of meropenem reduce a composite of mortality and emerg...

ORIGINAL ARTICLE Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure Peter J. Blankestijn, Robin W.M. Vernooij, Carinna Hockham, et al N Engl J Med June 16, 2023DOI: 10.1056/NEJMoa2304820 Abstract BACKGROUND Several studies have suggested that patients with kidney failure may benefit from high-dose hemodiafiltration as compared with standard hemodialysis. However, given the limitations of the various published studies, additional d...

Original Investigation  Caring for the Critically Ill Patient May 21, 2023 Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial J. Randall Curtis, Robert Y. Lee, Lyndia C. Brumback, et al JAMA. 2023;329(23):2028-2037. doi:10.1001/jama.2023.8812 Key Points Question  Can a patient-specific, clinician-facing communication-priming intervention (Jumpst...

ARTICLES|ONLINE FIRST Implementation of point-of-care testing of C-reactive protein concentrations to improve antibiotic targeting in respiratory illness in Vietnamese primary care: a pragmatic cluster-randomised controlled trial Nga Thi Thuy Do, Tien Viet Dung Vu, Rachel C Greer, et al. Lancet Infect Dis Published: May 22, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00125-1 Summary Background In previous trials, point-of-care testing of C-reactive...

ORIGINAL ARTICLE Early versus Later Anticoagulation for Stroke with Atrial Fibrillation Urs Fischer, Masatoshi Koga, Daniel Strbian, et al N Engl J Med May 24, 2023DOI: 10.1056/NEJMoa2303048 Abstract BACKGROUND The effect of early as compared with later initiation of direct oral anticoagulants (DOACs) in persons with atrial fibrillation who have had an acute ischemic stroke is unclear. METHODS We performed an investigator-initiated, open-label tria...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalIntensivist physician-to-patient ratios and mortality in the intensive care unitKahn J.M.. et al. OPEN ACCESS ~ What's New in Intensive CareWhat’s new in therapeutic drug monitoring of antimicrobials?Sjövall F., Lanckohr C. and Bracht H. Ventilator associated tracheobronchitis and pneumonia: one infection with two facesMartin-Loeches I., Povoa P. and Nseir S. To mobilise or not to mobilise: is that the righ...

Original Investigation  Caring for the Critically Ill Patient May 21, 2023 Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial J. Randall Curtis, Robert Y. Lee, Lyndia C. Brumback, et al JAMA. Published online May 21, 2023. doi:10.1001/jama.2023.8812 Key Points Question  Can a patient-specific, clinician-facing communication-priming intervention ...

Medical News & Perspectives  May 3, 2023 Artificial Intelligence, Emerging Threats, and Diagnostic Advances—Highlights From ECCMID, Europe’s Largest Infectious Disease Conference Preeti Malani JAMA. Published online May 3, 2023. doi:10.1001/jama.2023.6066 For more than 14 000 infectious diseases physicians, clinical microbiologists, and public health professionals, gathering in Copenhagen, Denmark, in April was a special occasion. The Eur...