ARTICLES| VOLUME 4, ISSUE 8, E632-E641, AUGUST 2023Download Full Issue Viral and antibody dynamics of acute infection with SARS-CoV-2 omicron variant (B.1.1.529): a prospective cohort study from Shenzhen, China Yang Yang, Liping Guo, Jing Yuan, et al Lancet Microbe 2023; 8: E632-E641 Published:July 14, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00139-8 Summary Background Elucidating viral dynamics within the host is important for desig...

ARTICLES| VOLUME 4, ISSUE 8, E591-E600, AUGUST 2023Download Full Issue Evaluating the relationship between community water and sanitation access and the global burden of antibiotic resistance: an ecological study Erica R Fuhrmeister, Abigail P Harvey, Maya L Nadimpalli, et al Lancet Microbe 2023; 4: E591-E600 Published:June 30, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00137-4 Summary Background Antibiotic resistance is a leading c...

ORIGINAL ARTICLE Health Consequences of Thymus Removal in Adults Kameron A. Kooshesh, Brody H. Foy, David B. Sykes, et al N Engl J Med 2023; 389:406-417DOI: 10.1056/NEJMoa2302892 Abstract BACKGROUND The function of the thymus in human adults is unclear, and routine removal of the thymus is performed in a variety of surgical procedures. We hypothesized that the adult thymus is needed to sustain immune competence and overall health. METHODS We evalua...

ORIGINAL ARTICLE Extracorporeal Life Support in Infarct-Related Cardiogenic Shock Holger Thiele, Uwe Zeymer, Ibrahim Akin, et al N Engl J Med August 26, 2023DOI: 10.1056/NEJMoa2307227 Abstract BACKGROUND Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack of evidence regarding its effect on mortality. METHODS In this multicenter trial, patients with acute myocardial infarction...

ARTICLES|ONLINE FIRST Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a prospective cohort study Alexander M Aiken, Andrea M Rehman, Marlieke E A de Kraker, et al Lancet Infect Dis Published:July 13, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00233-5 Summary Background Bacteria of the order Enterobacterales are common pathogens causing bl...

ARTICLES| VOLUME 23, ISSUE 8, P945-955, AUGUST 2023Download Full Issue Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial Nathan J Brendish, Kate R Beard, Ahalya K Malachira, et al Lancet Infect Dis 2023; 8: 945-955 Published:April 25, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00066-X ...

Original Investigation  August 15, 2023 Door-in-Door-out Times for Interhospital Transfer of Patients With Stroke Brian Stamm, Regina Royan, Mihai Giurcanu, et al JAMA. 2023;330(7):636-649. doi:10.1001/jama.2023.12739 Key Points Question  What is the median door-in-door-out time for interhospital transfer of patients with stroke, and what patient and hospital-level factors are associated with door-in-door-out time? Findings&nb...

ARTICLES|ONLINE FIRST Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial Jean-Christophe Richard, Nicolas Terzi, Hodane Yonis, et al Lancet Respir Med Published:July 12, 2023DOI:https://doi.org/10.1016/S2213-2600(23)00221-7 Summary Background COVID-19-related acute respiratory distress syndrome (ARDS) is associated with a high mortality rate and longer mechanical ...

Original Investigation  Less Is More July 3, 2023 Hospital Culture and Intensity of End-of-Life Care at 3 Academic Medical Centers Elizabeth Dzeng, Jason N. Batten, Daniel Dohan, et al JAMA Intern Med. Published online July 3, 2023. doi:10.1001/jamainternmed.2023.2450 Key Points Question  What is the role of hospital culture and institutional structures in the provision of potentially nonbeneficial, high-intensity life-sustain...

Original Investigation  July 25, 2023 Identifying Children Likely to Benefit From Antibiotics for Acute Sinusitis: A Randomized Clinical Trial Nader Shaikh, Alejandro Hoberman, Timothy R. Shope, et al JAMA. 2023;330(4):349-358. doi:10.1001/jama.2023.10854 Key Points Question  In children aged 2 to 11 years with acute sinusitis, does the efficacy of antibiotic treatment differ based on nasopharyn...