Original Investigation  July 17, 2023 Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial John R. Sims, Jennifer A. Zimmer, Cynthia D. Evans, et al JAMA. 2023;330(6):512-527. doi:10.1001/jama.2023.13239 Key Points Question  Does donanemab, a monoclonal antibody designed to clear brain amyloid plaque, provide clinical benefit in early symptomatic Alzheimer...

Original Investigation  August 8, 2023 Sugar-Sweetened and Artificially Sweetened Beverages and Risk of Liver Cancer and Chronic Liver Disease Mortality Longgang Zhao, Xinyuan Zhang, Mace Coday, et al JAMA. 2023;330(6):537-546. doi:10.1001/jama.2023.12618 Key Points Question  Is greater intake of sugar-sweetened beverages associated with greater risk of liver cancer or chronic liver disease mort...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalEpidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical studyZarbock A. et al.  ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenationStephens A.F. et al. Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre...

Original Investigation  Association of VA Surgeons May 17, 2023 Rates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020 Mytien Nguyen, Luis Gonzalez, Ashley Newman, et al JAMA Surg. 2023;158(7):756-764. doi:10.1001/jamasurg.2023.1571 Key Points Question  How has National Institutes of Health (NIH) funding to surgeon-scientists changed between 1995 and 2020? Findings &nb...

Original Investigation  August 2, 2023 Intraoperative Identification of Thyroid and Parathyroid Tissues During Human Endocrine Surgery Using the MasSpec Pen Rachel J. DeHoog, Mary E. King, Michael F. Keating, et al JAMA Surg. Published online August 2, 2023. doi:10.1001/jamasurg.2023.3229 Key Points Question  Does the metabolic information provided by the MasSpec Pen (MSPen) technology enable in...

Original Investigation  August 2, 2023 Outcomes for High-Risk Surgical Procedures Across High- and Low-Competition Hospital Markets Sherri R. Thumma, Shukri H. A. Dualeh, Nicholas J. Kunnath, et al JAMA Surg. Published online August 2, 2023. doi:10.1001/jamasurg.2023.3221 Key Points Question  What is the association between hospital market competition and patient outcomes after high-risk surgery...

Original Investigation  May 3, 2023 Diagnostic Accuracy of Unenhanced Computed Tomography for Evaluation of Acute Abdominal Pain in the Emergency Department Hiram Shaish, Justin Ream, Chenchan Huang, et al JAMA Surg. 2023;158(7):e231112. doi:10.1001/jamasurg.2023.1112 Key Points Question  What is the diagnostic accuracy of unenhanced computed tomography (CT) in patients admitted to an emergency department with abdominal pain? Findings&n...

Original Investigation  May 10, 2023 Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer: A Randomized Clinical Trial Myrick C. Shinall Jr, Sara F. Martin, Mohana Karlekar, et al JAMA Surg. 2023;158(7):747-755. doi:10.1001/jamasurg.2023.1396 Key Points Question  Should patients undergoing nonpalliative surgery for cancer receive early specialist palliative care? Findings  In this ra...

Original Investigation  May 17, 2023 Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins Trine O. Eskesen, Martin Sillesen, Jacob Krabbe Pedersen, et al JAMA Surg. 2023;158(7):738-745. doi:10.1001/jamasurg.2023.1560 Key Points Question  Is moderate to severe trauma associated with long-term increased risk of death or immune-mediated or cancer disease? Findings  In this nat...

Original Investigation  April 26, 2023 Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies Matthew R. Thau, Ted Liu, Neha A. Sathe, et al JAMA Surg. 2023;158(7):728-736. doi:10.1001/jamasurg.2023.0819 Key Points Question  Are trauma molecular endotypes associated with clinical outcomes and differential response to transfusion resuscitation strategies? Findings  In this s...