ORIGINAL ARTICLE Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU Jan Gunst, Yves Debaveye, Fabian Güiza, et al N Engl J Med 2023; 389:1180-1190DOI: 10.1056/NEJMoa2304855 Abstract BACKGROUND Randomized, controlled trials have shown both benefit and harm from tight blood-glucose control in patients in the intensive care unit (ICU). Variation in the use of early parenteral nutrition and in insulin-induced severe hypoglycemia might ...

ARTICLES|ONLINE FIRST Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial Jean-Christophe Richard, Nicolas Terzi, Hodane Yonis, et al. Lancet Respir Med Published:July 12, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00221-7 Summary Background COVID-19-related acute respiratory distress syndrome (ARDS) is associated with a high mortality rate and longer mechan...

Original Investigation  August 23, 2023 Timing of Cholecystectomy After Moderate and Severe Acute Biliary Pancreatitis Marcello Di Martino, Benedetto Ielpo, Francesco Pata, et al JAMA Surg. Published online August 23, 2023. doi:10.1001/jamasurg.2023.3660 Key Points Question  Is performing early cholecystectomy in patients with moderately severe and severe acute biliary pancreatitis (ABP) safe? ...

Original Investigation  July 17, 2023 Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial Ana Maria Copaescu, Sara Vogrin, Fiona James, et al JAMA Intern Med. Published online July 17, 2023. doi:10.1001/jamainternmed.2023.2986 Key Points Question  Is direct oral penicillin challenge in adults with...

Original Investigation  August 7, 2023 Prospective Associations of Different Combinations of Aerobic and Muscle-Strengthening Activity With All-Cause, Cardiovascular, and Cancer Mortality Rubén López-Bueno, Matthew Ahmadi, Emmanuel Stamatakis, et al JAMA Intern Med. Published online August 7, 2023. doi:10.1001/jamainternmed.2023.3093 Key Points Question  What is the optimal combination of modera...

Original Investigation  August 22/29, 2023 Extracranial-Intracranial Bypass and Risk of Stroke and Death in Patients With Symptomatic Artery Occlusion: The CMOSS Randomized Clinical Trial Yan Ma, Tao Wang, Haibo Wang, et al JAMA. 2023;330(8):704-714. doi:10.1001/jama.2023.13390 Key Points Question  Among symptomatic patients with atherosclerotic occlusion of the internal carotid artery (ICA) or middle cerebral artery (MCA) with e...

Original Investigation  July 24, 2023 Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic Jacob Wallace, Paul Goldsmith-Pinkham, Jason L. Schwartz JAMA Intern Med. Published online July 24, 2023. doi:10.1001/jamainternmed.2023.1154 Key Points Question  Was political party affiliation a risk factor associated with excess mortality during the COVID-19 pandemic in Flori...

Original Investigation  August 16, 2023 Outcomes Following Lung Transplant for COVID-19–Related Complications in the US Panagiotis Tasoudis, Leonard J. Lobo, Raymond D. Coakley, et al JAMA Surg. Published online August 16, 2023. doi:10.1001/jamasurg.2023.3489 Key Points Question  What are the outcomes following lung transplant for COVID-19–related complications? Findings  In this co...

ORIGINAL ARTICLE Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons Lisa L. Barnes, Klodian Dhana, Xiaoran Liu, et al N Engl J Med 2023; 389:602-611DOI: 10.1056/NEJMoa2302368 Abstract BACKGROUND Findings from observational studies suggest that dietary patterns may offer protective benefits against cognitive decline, but data from clinical trials are limited. The Mediterranean–DASH Intervention for Neurodegenerative Delay, known a...

Original Investigation  August 15, 2023 Prenatal Intravenous Magnesium at 30-34 Weeks’ Gestation and Neurodevelopmental Outcomes in Offspring: The MAGENTA Randomized Clinical Trial Caroline A. Crowther, Pat Ashwood, Philippa F. Middleton, et al JAMA. 2023;330(7):603-614. doi:10.1001/jama.2023.12357 Key Points Question  Does intravenous magnesium sulfate for pregnant individuals at risk of delive...