Original Investigation  October 23, 2023 Multitarget Stool RNA Test for Colorectal Cancer Screening Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, et al JAMA. Published online October 23, 2023. doi:10.1001/jama.2023.22231 Key Points Question  What is the performance of the novel multitarget stool RNA (mt-sRNA) test (ColoSense) for individuals 45 years and older undergoing colorectal ca...

A Case Study in Artificial Intelligence-Generated Manuscripts Michael N. Kammer Chest 2023; 164: 478-480 DOI:https://doi.org/10.1016/j.chest.2023.05.003 “Write a review article on the use of bronchoscopy to diagnose lung cancer, use scientific vocabulary, cite your sources.” Text started to scroll across the screen; it was well written, plausible, and generated by artificial intelligence (AI), the newest tool based on the generative pretrained transformer mode...

Research Letter  October 30, 2023 Gender Gap in Leadership of Clinical Trials Ithai Waldhorn, David Bomze, Irit Ben-Aharon, et al JAMA Intern Med. Published online October 30, 2023. doi:10.1001/jamainternmed.2023.5104 Clinical trials provide the highest-quality evidence and remain the bedrock for clinical decision-making. They require participation of numerous patients, enormous resources, and substantial fu...

Research Effect of invitation letter in language of origin on screening attendance: randomised controlled trial in BreastScreen Norway Solveig Hofvind, Nadia Iqbal, Jonas E Thy, et al BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2023-075465 (Published 19 September 2023)Cite this as: BMJ 2023;382:e075465 Abstract Objective To explore attendance at organised mammographic screening among immigrant groups that received an invitation letter and informatio...

ORIGINAL RESEARCH|ARTICLES IN PRESS Epidemiology and clinical patterns of Lung Abscesses in ICU: A French multicenter retrospective study Vinca Montmeat, Vincent Bonny, Tomas Urbina, et al Chest Published:August 28, 2023 DOI:https://doi.org/10.1016/j.chest.2023.08.020 Abstract Background Data are scarce regarding epidemiology and management of critically ill patients with lung abscesses. Research question What are the clinical and microbiologica...

ORIGINAL RESEARCH|ARTICLES IN PRESS Oxygen therapy in patients with intermediate-risk acute pulmonary embolism: a randomized trial Deisy Barrios, Diego Durán, Carmen Rodríguez, et al Chest Published:September 15, 2023 DOI:https://doi.org/10.1016/j.chest.2023.09.007 ABSTRACT Background The effect of supplemental oxygen therapy in patients with intermediate-risk pulmonary embolism (PE) who do not have hypoxemia at baseline is uncertain. Research Ques...

ORIGINAL RESEARCH|ARTICLES IN PRESS Comparative effectiveness of first-line and alternative antibiotic regimens in hospitalized patients with non-severe community acquired pneumonia: A multi-centre retrospective cohort study Anthony D. Bai, Siddhartha Srivastava, Benjamin KC. Wong, et al Chest Published:August 10, 2023 DOI:https://doi.org/10.1016/j.chest.2023.08.008 Abstract Background There are several antibiotic regimens to treat community-acquired ...

JOURNAL ARTICLE Burden of Respiratory Viruses in Children Less Than 2 Years Old in a Community-based Longitudinal US Birth Cohort  Zheyi Teoh,  Shannon Conrey,  Monica McNeal,  et al Clinical Infectious Diseases, Volume 77, Issue 6, 15 September 2023, Pages 901–909 https://doi.org/10.1093/cid/ciad289 Abstract Background Respiratory viral infections are a major cause of morbidity and hospitalization in young children. Nevertheless, the population burde...

ORIGINAL RESEARCH|ARTICLES IN PRESS Low- Versus Conventional-Dose Trimethoprim-Sulfamethoxazole Treatment for Pneumocystis Pneumonia in Non-Human Immunodeficiency Virus-Infected Patients: A Multi-Center, Retrospective Observational Cohort Study Tatsuya Nagai, Hiroki Matsui, Haruka Fujioka, et al Chest Open AccessPublished:August 10, 2023 DOI:https://doi.org/10.1016/j.chest.2023.08.009 Abstract Background Trimethoprim-sulfamethoxazole (TMP-SMX) is an e...

Original Investigation  October 24/31, 2023 Traditional Chinese Medicine Compound (Tongxinluo) and Clinical Outcomes of Patients With Acute Myocardial Infarction: The CTS-AMI Randomized Clinical Trial Yuejin Yang, Xiangdong Li, Guihao Chen, et al JAMA. 2023;330(16):1534-1545. doi:10.1001/jama.2023.19524 Key Points Question  Among patients with acute ST-segment elevation myocardial infarction (STEMI), does the addition of a tradit...