Preliminary Communication  September 12, 2023 Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients Jingcheng Zhao, Klaus Rostgaard, Elsa Lauwers, et al JAMA. 2023;330(10):941-950. doi:10.1001/jama.2023.14445 Key Points Question  Is there an association between the occurrence of spontaneous intracerebral hemorrhage among blood donors and the risk of spontaneous intracerebral hemorrhage in patients who recei...

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 164, ISSUE 3, P596-605, SEPTEMBER 2023 Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19: A Multicenter Observational Cohort Study Lisa M. Hessels, Esther Speksnijder, Nienke Paternotte, et al Chest 2023; 164: 596-605 Published:April 26, 2023 DOI:https://doi.org/10.1016/j.chest.2023.04.032 Background Despite the low rate of bacterial coinfection, antibiotics are very commonly prescribed in ...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 164, ISSUE 3, P656-666, SEPTEMBER 2023 Outcomes in Patients Perceived as Receiving Excessive Care by ICU Physicians and Nurses: Differences Between Patients < 75 and ≥ 75 Years of Age? Ruth D. Piers, Valerie Banner-Goodspeed, Eva Åkerman, et al Chest 2023; 164: 656-666 Published:April 13, 2023 DOI:https://doi.org/10.1016/j.chest.2023.04.018 Background The benefit of the ICU for older patients is often debated. ...

Original Investigation  Caring for the Critically Ill Patient October 12, 2023 Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial Jan O. Jansen, Jemma Hudson, Claire Cochran, et al JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.20850 Key Points Question  Does the addition of resuscitative endova...

Interrater Reliability of the 2015 Pediatric Acute Lung Injury Consensus Conference Criteria for Pediatric ARDS Layne Silver, Daniel Kaplan, Jessica Asencio, et al Chest 2023; 164: 650-655 Published:April 14, 2023 DOI:https://doi.org/10.1016/j.chest.2023.04.019 Background Diagnostic guidelines for pediatric ARDS (PARDS) were developed at the 2015 Pediatric Acute Lung Injury Consensus Conference (PALICC). Although this was an improvement in creating pediatri...

Original Investigation  September 11, 2023 Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial Peter A. Dargaville, C. Omar F. Kamlin, Francesca Orsini, et al JAMA. Published online September 11, 2023. doi:10.1001/jama.2023.15694 Key Points Question  For preterm infants with respiratory distress syndrome supported with continuous positive airway p...

Original Investigation  Caring for the Critically Ill Patient October 12, 2023 Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial Deborah M. Siegal, Emilie P. Belley-Côté, Shun Fu Lee, et al JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.20820 Key Points Question  Does transitioning from standard-volume to small-volume blood collection tubes for l...

Original Investigation  Caring for the Critically Ill Patient October 12, 2023 Red Blood Cell Transfusion in the Intensive Care Unit Senta Jorinde Raasveld, Sanne de Bruin, Merijn C. Reuland, et al JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.20737 Key Points Question  What were transfusion practices worldwide among patients admitted to the intensive care unit (ICU)? Findings  In this internation...

ORIGINAL ARTICLE Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults Joseph Donovan, Nguyen D. Bang, Darma Imran, et al N Engl J Med 2023; 389:1357-1367DOI: 10.1056/NEJMoa2216218 Abstract BACKGROUND Adjunctive glucocorticoids are widely used to treat human immunodeficiency virus (HIV)–associated tuberculous meningitis despite limited data supporting their safety and efficacy. METHODS We conducted a double-blind, randomized, p...

Original Investigation  September 5, 2023 Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke: The OPTIMAL-BP Randomized Clinical Trial Hyo Suk Nam, Young Dae Kim, JoonNyung Heo, et al JAMA. 2023;330(9):832-842. doi:10.1001/jama.2023.14590 Key Points Question  Does early intensive blood pressure management improve outcomes after successful reperfusion with endovascular thromb...