Research Optimal timing of influenza vaccination in young children: population based cohort study Christopher M Worsham, Charles F Bray, Anupam B Jena BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077076 (Published 21 February 2024)Cite this as: BMJ 2024;384:e077076 Abstract Objective To assess optimal timing of influenza vaccination in young children. Design Population based cohort study. Setting United States. Participants&nb...

ARTICLES|ONLINE FIRST National, regional, and global estimates of low birthweight in 2020, with trends from 2000: a systematic analysis Yemisrach B Okwaraji, Julia Krasevec, Ellen Bradley, et al Lancet Published: February 28, 2024 DOI: https://doi.org/10.1016/S0140-6736(23)01198-4 Summary Background Low birthweight (LBW; <2500 g) is an important predictor of health outcomes throughout the life course. We aimed to update country, regional, and globa...

Original Investigation  February 26, 2024 Racial Differences in Shared Decision-Making About Critical Illness Deepshikha C. Ashana, Whitney Welsh, Doreet Preiss, et al JAMA Intern Med. Published online February 26, 2024. doi:10.1001/jamainternmed.2023.8433 Key Points Question  How do critical care clinicians approach shared decision-making with Black compared with White caregivers of critically ill patients? Findings &nbs...

Original Investigation  February 26, 2024 COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes Abinet M. Aklilu, Sanchit Kumar, James Nugent, et al JAMA Intern Med. Published online February 26, 2024. doi:10.1001/jamainternmed.2023.8225 Key Points Question  Are hospitalized patients who develop acute kidney injury (AKI) associated with COVID-19 at risk of worse kidney function trajectory and higher mortality t...

Original Investigation  June 6, 2023 Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial Ajit P. Limaye, Klemens Budde, Atul Humar, et al JAMA. 2023;330(1):33-42. doi:10.1001/jama.2023.9106 Key Points Question  Is prophylaxis with letermovir noninferior to valganiclovir for cytomegalovirus (CMV) disease prevention in high-risk CMV-seronegative kidney transpl...

ORIGINAL ARTICLE Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection Gregory W. Albers, Mouhammad Jumaa, Barbara Purdon, et al N Engl J Med 2024; 390:701-711DOI: 10.1056/NEJMoa2310392 Abstract BACKGROUND Thrombolytic agents, including tenecteplase, are generally used within 4.5 hours after the onset of stroke symptoms. Information on whether tenecteplase confers benefit beyond 4.5 hours is limited. METHODS We conducted a mul...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 165, ISSUE 2, P348-355, FEBRUARY 2024 Peripheral Administration of Norepinephrine: A Prospective Observational Study Jason R. Yerke, Eduardo Mireles-Cabodevila, Alyssa Y. Chen, et al Chest 2024; 165: 348-355 Published:August 20, 2023 DOI:https://doi.org/10.1016/j.chest.2023.08.019 Background Historically, norepinephrine has been administered through a central venous catheter (CVC) because of concerns about the risk o...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 165, ISSUE 2, P333-347, FEBRUARY 2024 Low Tidal Volume Ventilation Is Poorly Implemented for Patients in North American and United Kingdom ICUs Using Electronic Health Records Romit J. Samanta, Ari Ercole, Steven Harris, et al Chest 2024; 165: 333-347 Published:September 27, 2023 DOI:https://doi.org/10.1016/j.chest.2023.09.021 Background Low tidal volume ventilation (LTVV; < 8 mL/kg predicted body weight...

Original Investigation  January 30, 2024 Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula: A Randomized Clinical Trial Tarah T. Colaizy, Brenda B. Poindexter, Scott A. McDonald, et al JAMA. 2024;331(7):582-591. doi:10.1001/jama.2023.27693 Key Points Question  Among extremely preterm infants fed minimal maternal milk, does feeding of donor human milk compared with preterm formula du...

Original Investigation  Pediatrics February 14, 2024 Hospital-Level NICU Capacity, Utilization, and 30-Day Outcomes in Texas David C. Goodman, Patrick Stuchlik, Cecilia Ganduglia-Cazaban, et al JAMA Netw Open. 2024;7(2):e2355982. doi:10.1001/jamanetworkopen.2023.55982 Key Points Question  Is hospital-level neonatal intensive care unit (NICU) bed supply associated with higher risk-adjusted newborn utilization and better outcome...