Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study Zarbock, A., Weiss, R., Albert, F. et al. Intensive Care Med 49, 1441–1455 (2023) https://doi.org/10.1007/s00134-023-07169-7 Abstract Purpose The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries and health care systems is u...

Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial Obling, L.E.R., Beske, R.P., Meyer, M.A.S. et al. Intensive Care Med 2023; 49: 1467–1478 Abstract Purpose Patients who are successfully resuscitated following out-of-hospital cardiac arrest (OHCA) are still at a high risk of neurological damage and death. Inflammation and brain injury are components of the post-cardiac arr...

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial Raffaele Di Fenza,  Naman S. Shetty,  Stefano Gianni, et al Am J Respir Crit Care Med 2023; 208: 1293-1304 Abstract Rationale: The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown. Objectives: The primary outcome was the change in arterial oxygenation (PaO2...

The Minnesota Medical Operations Coordination Center: A COVID-19 Statewide Response to Ensure Access to Critical Care and Medical-Surgical Beds Karyn D. Baum, Lauren Vlaanderen, Walter James, et al Chest 2024; 165: 95-109 Background COVID-19 led to unprecedented inpatient capacity challenges, particularly in ICUs, which spurred development of statewide or regional placement centers for coordinating transfer (load-balancing) of adult patients needing intensive ...

ONLINE FIRST (FREE ACCESS) TOP 6 MOST CITED ARTICLES IN 2023 OriginalEchocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID studyHuang S. et al. Direct assessment of microcirculation in shock: a randomized-controlled multicenter studyRomano Bruno R. et al. Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care...

ORIGINAL ARTICLE Skin Antisepsis before Surgical Fixation of Extremity Fractures The PREP-IT Investigators N Engl J Med 2024; 390:409-420DOI: 10.1056/NEJMoa2307679 BACKGROUND Studies evaluating surgical-site infection have had conflicting results with respect to the use of alcohol solutions containing iodine povacrylex or chlorhexidine gluconate as skin antisepsis before surgery to repair a fractured limb (i.e., an extremity fracture). METHODS In a cl...

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 165, ISSUE 1, P68-78, JANUARY 2024 Comparative Effectiveness of First-Line and Alternative Antibiotic Regimens in Hospitalized Patients With Nonsevere Community-Acquired Pneumonia: A Multicenter Retrospective Cohort Study Anthony D. Bai, Siddhartha Srivastava, Benjamin K.C. Wong, et al Chest 2024; 165: 68-78 Published: August 10, 2023 DOI: https://doi.org/10.1016/j.chest.2023.08.008 Background There are several...

Research Letter  Health Care Policy and Law January 2, 2024 Automated External Defibrillator Use After Out-of-Hospital Cardiac Arrest at Recreational Facilities Ahmed A. Kolkailah, Paul S. Chan, Qiang Li, et al JAMA Intern Med. Published online January 2, 2024. doi:10.1001/jamainternmed.2023.7248 Out-of-hospital cardiac arrest (OHCA) during exercise is often due to a ventricular arrhythmia for which prompt defibrillation from an automated ...

ARTICLES| VOLUME 24, ISSUE 1, P36-45, JANUARY 2024 Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial William H K Schilling, Podjanee Jittamala, James A Watson, et al Lancet Infect Dis 2024; 24: 36-45 DOI:https://doi.org/10.1016/S1473-3099(23)00493-0 Summary Background Molnupiravir and ritonavir-boosted nirmatrelv...

Original Investigation  November 22, 2023 Risk of Mortality Following Surgery in Patients With a Previous Cardiovascular Event Christos V. Chalitsios, Matthew S. Luney, William A. Lindsay, et al JAMA Surg. Published online November 22, 2023. doi:10.1001/jamasurg.2023.5951 Key Points Question  Is the time elapsed since a cardiovascular event associated with an increased risk of mortality in patie...