Editorial  October 14, 2023 Acute Kidney Injury With Empirical Antibiotics for Sepsis Steven Y. C. Tong, Balasubramanian Venkatesh, Erin K. McCreary JAMA. Published online October 14, 2023. doi:10.1001/jama.2023.18591 Sepsis describes life-threatening organ dysfunction due to a dysregulated host response to infection. It is a global health priority affecting 55 million people worldwide causing 11 million deaths annually.1 Failure to init...

Comment & Response  September 18, 2023 Xuebijing Injection for Sepsis Treatment: When Will It Be Approved Outside of China? Tianyang Hu JAMA Intern Med. Published online September 18, 2023. doi:10.1001/jamainternmed.2023.4398 To the Editor A recent study by Liu and colleagues1 reported a reduction in 28-day mortality in patients with sepsis treated with Xuebijing (XBJ), a Chinese medicine compounded injection, compared with plac...

Surgical Stabilisation of Rib Fractures in Chest Wall Injury A new study compared the effectiveness of surgical stabilisation of rib fractures (SSRF) to non-operative management in cases of severe chest wall injury. The effectiveness of SSRF has been demonstrated in patients with clinical flail chest and respiratory failure. However, the impact of SSRF on outcomes in cases of severe chest wall injuries without clinical flail chest remains uncertain. This stud...

Editorial  September 12, 2023 Blood Transfusion and Brain Amyloidosis: Should We Be Worried? Steven M. GreenbergJAMA. 2023;330(10):921-922. doi:10.1001/jama.2023.14522 Is misfolding of the amyloid β peptide—the primary constituent of senile plaques in Alzheimer disease and toxic cerebral vessel wall deposits in cerebral amyloid angiopathy (CAA)1—contagious? Data from experimental and clinical sources argue that prion-like transmission of amyloid β mi...

Real Time Early Warning System Using Machine Learning Delayed recognition of haemodynamic and respiratory deterioration in hospitalised patients is linked to increased morbidity and mortality. Measures have been developed to improve the recognition of acute deterioration and reduce the occurrence of major adverse events like all-cause mortality and unplanned ICU admission. One such measure is the implementation of Early Warning Scores (EWS), including widely used s...

Editorial  October 12, 2023 Contemporary Adjuncts to Hemorrhage Control Samuel A. Tisherman, Megan L. Brenner JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.16135 Trauma remains the most common cause of death among people 1 to 45 years of age, with hemorrhage being the most common cause of preventable death. For patients with hemorrhagic shock, expeditious control of bleeding is required to maximize chances for survival. Hemostasis...

Editorials NSAIDs, hormonal contraception, and venous thromboembolism Morten Schmidt BMJ 2023; 382 doi: https://doi.org/10.1136/bmj.p1990 (Published 06 September 2023)Cite this as: BMJ 2023;382:p1990 A harmful drug interaction that deserves more attention Venous thromboembolism is a multifactorial disease, involving interactions between inherited and acquired risk factors such as immobilisation, active cancer, trauma or fracture, recent surgery, and—in youn...

Health Disparities in ECMO A recent review explored the extent and quality of literature investigating the influence of social determinants of health (SDoH) on extracorporeal membrane oxygenation (ECMO) utilisation and outcomes among children and adults. The researchers examined the relationship between factors like socioeconomic status, education, and access to healthcare with the use and effectiveness of ECMO. A total of 219 publications were identified. The p...

Editorial  October 12, 2023 Precision in Transfusion Medicine Matthew D. Neal, Beverley J. Hunt JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.16134 Blood transfusion management has come a long way since the introduction of blood banks in the 1930s, leading to the widespread use of plasma and blood in the Second World War. The gradual introduction of blood components, such as platelets and cryoprecipitate, occurred in the foll...

Editorial  September 5, 2023 Blood Pressure Management After Successful Thrombectomy Amrou Sarraj JAMA. 2023;330(9):811-812. doi:10.1001/jama.2023.14588 Despite the success of endovascular therapy (EVT) in acute ischemic stroke due to large vessel occlusion,1-3opportunities to further optimize clinical outcomes remain. One such avenue is to reduce hemorrhagic transformation in the infarcted tissue bed after successful reperfusion, which has b...