Sepsis-Associated Acute Kidney Injury in the ICU Sepsis is a frequently encountered condition that leads to severe illness and is associated with significant morbidity and mortality. It is commonly accompanied by acute kidney injury (AKI), known as sepsis-associated acute kidney injury (SA-AKI). The relationship between sepsis and AKI has been investigated in prior studies. However, the absence of a consistent and standardised definition has hindered the interpreta...

Intraoperative Oxygen Administration in OPCAB Maintaining adequate oxygen delivery (DO2) to peripheral tissues during surgery is crucial, as factors like acute blood loss or fluid shifts can threaten oxygen supply. Surgery patients often receive higher fractions of inspired oxygen (FiO2) to ensure sufficient oxygen and perfusion. However, this practice can lead to supraphysiological oxygen levels, resulting in oxidative stress, vasoconstriction, and microcirculator...

Tranexamic Acid for Intracerebral Haemorrhage in Patients on NOAC There is a lack of evidence-based haemostatic treatment for intracerebral haemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOACs). Tranexamic acid (TXA) is an antifibrinolytic drug that helps limit haematoma expansion. A study was conducted to evaluate the effectiveness and safety of using TXA in NOAC-related ICH cases. The trial was performed at six Swiss stroke centres...

Invited Commentary  Pediatrics July 20, 2020 Leveraging Tweets, Citations, and Social Networks to Improve Bibliometrics N. Seth Trueger, Yusuf Yilmaz, Teresa M. Chan JAMA Netw Open. 2020;3(7):e2010911. doi:10.1001/jamanetworkopen.2020.10911 Citations have long been the leading metric for articles, with the citation-based journal impact factor being the primary journal metric. As the world becomes increasingly digital, altmetrics (“alternat...

Editorial  October 25, 2023 Vitamin C for Patients With COVID-19: More Evidence of Lack of Efficacy in Patients With Sepsis Craig S. Jabaley, Craig M. Coopersmith JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.18592 Vitamin C is an essential nutrient, functioning as an antioxidant, immunomodulator, and cofactor for numerous enzymes. Vitamin C represents the definitive treatment for scurvy, which results from vitamin C deficien...

Editorial  October 25, 2023 Sigh Breaths for Trauma Patients Receiving Mechanical Ventilation: Take a Deep Breath Giacomo Bellani, Antonio Pesenti JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.21744 Occasionally, newspapers report positive stories of animal species believed to be extinct, only to be discovered alive and repopulating their habitats.1 In this issue of JAMA, Albert and colleagues2 assessed the rol...

The Promise of Artificial Intelligence in Critical Care Computer-based technologies, including artificial intelligence (AI) applications like ChatGPT and DALL-E, are being increasingly used and can mimic human capabilities, even passing medical board examinations. Retrospective studies have shown that machine learning (ML) applications are especially valuable in the ICU due to their diagnostic and prognostic capabilities, leveraging the vast amount of available dat...

Viewpoint  September 29, 2023 COVID-19 Therapeutics for Nonhospitalized Patients—Updates and Future Directions Kara W. Chew, Preeti N. Malani, Rajesh T. Gandhi JAMA. Published online September 29, 2023. doi:10.1001/jama.2023.19542 Antiviral therapeutics for COVID-19 in nonhospitalized patients prevent progression to severe illness, hospitalization, and death. Despite their proven benefit, utilization of these therapies remains low. This Viewp...

Editorial  October 25, 2023 β-Blockers in Patients With Sepsis: Putting the Puzzle Together, Piece by Piece Steven M. Hollenberg JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.20455 Challenging conventional wisdom is important and frequently useful. Septic shock is a form of distributive shock in which hypotension results from vasodilation.1 Although myocardial performance may not always be entirely normal, a phenomenon t...

Invited Commentary  September 20, 2023 New Technology and Bile Duct Injuries Liane S. Feldman, L. Michael Brunt JAMA Surg. Published online September 20, 2023. doi:10.1001/jamasurg.2023.4404 Thirty-five years ago, the rapid adoption of laparoscopic cholecystectomy ushered in the minimally invasive surgical revolution. Combining 2 preexisting and safe operations, this transformative innovation nonetheless resulted in unexpected patient harms: ...