Editor's Note  Aging and Health Intensive Chemoprophylaxis for Nursing Home Influenza Outbreaks—The Race Against Transmission Justin J. Choi, Sharon K. Inouye, Lona Mody JAMA Intern Med Published Online: March 30, 2026 doi: 10.1001/jamainternmed.2026.0409 Influenza outbreaks are common and lead to morbidity in nursing home (NH) residents. To limit transmission, clinical guidelines from the US Centers for Disease Control and Prevention and the Infect...

Editorial  Will the Bicarbonate for In-Hospital Cardiac Arrest Trial Change Practice? Clifton W. Callaway JAMA Published Online: June 11, 2026 doi: 10.1001/jama.2026.10508 In this issue of JAMA, Granfeldt and colleagues share results of the Bicarbonate for In-Hospital Cardiac Arrest randomized clinical trial comparing routine administration of sodium bicarbonate with placebo during attempted resuscitation of 779 patients with in-hospital cardiac arrest...

Editorial  High-Dose Vitamin C in Burns: Time to Stop David G. Greenhalgh JAMA Published Online: June 10, 2026 doi: 10.1001/jama.2026.10573 In this issue of JAMA, Stoppe and colleagues1 present the results of an international randomized clinical trial that provides evidence that high-dose intravenous vitamin C does not improve outcomes in patients with large burns. The data from the VICTORY trial even suggest that use of vitamin C in patients with larg...

Principles to Guide Intraoperative Mechanical Ventilation In ICU Thu, 5 Feb 2026 A recent article examines the principles underpinning intraoperative mechanical ventilation (MV) and synthesises current evidence to guide optimal ventilator settings during general anaesthesia. With more than 230 million patients worldwide undergoing surgery with MV each year, postoperative pulmonary complications (PPCs) remain common and are strongly associated with incr...

EDITORIAL TRACTION for Greater Surgical Use of Tranexamic Acid Michael F. Murphy, Ian Roberts N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMe2603105 Every year, many millions of surgical patients worldwide are unnecessarily exposed to a higher-than-necessary risk of blood transfusion because they do not receive a single dose of tranexamic acid just before the surgery. This failing is due not to a lack of high-quality scientific eviden...

Invasive & Non-Invasive Monitoring of Inspiratory Effort & Drive in Assisted Mechanical Ventilation In ICU Wed, 21 Jan 2026 A clinical review examined the invasive and non-invasive monitoring of inspiratory effort and respiratory drive in patients undergoing assisted mechanical ventilation (AMV). Following the acute phase of respiratory failure, AMV is commonly used to support spontaneous breathing, improve gas exchange, and reduce sedation req...

Editorial  Can Transesophageal Echocardiography–Guided CPR Improve Out-of-Hospital Cardiac Arrest Outcomes? Teva D. Brender, Tracy Y. Wang, Sharon K. Inouye, et al JAMA Intern Med Published Online: March 23, 2026 doi: 10.1001/jamainternmed.2026.0115 Worldwide, an estimated 3.8 million persons experience an out-of-hospital cardiac arrest (OHCA) annually.1 In the United States, only 8.2% of individuals with an OHCA survive with a favorable neurological o...

Acute Respiratory Distress Syndrome Molecular Phenotypes In ICU Wed, 21 Jan 2026 A new study investigated whether the two well-established molecular phenotypes of acute respiratory distress syndrome (ARDS)—hyperinflammatory and hypoinflammatory—are associated with distinct biological processes in the lung. Although these phenotypes were originally defined using plasma biomarkers and clinical variables and are known to differ in prognosis and treatment ...

How Different Oximeters Affect Clinical Decision-Making In ICU Wed, 28 Jan 2026 An observational method comparison study examined whether different pulse oximetry devices provide consistent nocturnal oxygen saturation measurements in stable adults treated with continuous positive airway pressure (CPAP) or long-term noninvasive ventilation (NIV). Although overnight pulse oximetry is widely recommended to detect residual sleep-disordered breathing (SDB),...

Editorial  Surveillance of Sepsis in Children—Making Every Case Count Luregn J. Schlapbach, Shu-Ling Chong, Nora Luethi JAMA Published Online: March 22, 2026 doi: 10.1001/jama.2026.2814 Sepsis is a leading cause of hospital admissions, mortality, and health care expenditure worldwide. It disproportionally affects very young and very old individuals. Sepsis in young individuals carries a magnified societal impact through potential years of life lost and...