Three-Year Mortality of ICU Survivors With Sepsis In Sepsis Tue, 10 Dec 2024 Sepsis is a common cause of ICU admissions and mortality, with its incidence increasing over recent decades. Although hospital mortality has declined, long-term mortality remains high, with 1-year mortality rates for survivors ranging from 7% to 44% and over 2-year mortality exceeding 53%. Factors contributing to this risk are debated, including the direct effects of sepsis, c...

Editor's Note  January 27, 2025 Decision Rules for Termination of Resuscitation—A Roadmap for Challenging Terrain Ilana B. Richman, Sharon K. Inouye, Tracy Wang JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7823 Cardiopulmonary resuscitation (CPR) algorithms generally begin with clear instructions: in the absence of a pulse, begin CPR. When to end resuscitative efforts, though, is much less obvious. Curren...

Safety of AI in Real-World Clinical Care In ICU Tue, 10 Dec 2024 The integration of AI tools into clinical practice is advancing rapidly, but mechanisms to ensure their safety and effectiveness remain insufficient. That is why healthcare organisations (HCOs) and clinicians face challenges in adopting AI responsibly.  Risks like model drift, algorithmic errors, biases, and overfitting have already been observed in early AI applications, resultin...

Editorials Surgical adverse events in the US Helen Haskell BMJ 2024; 387 doi: https://doi.org/10.1136/bmj.q2437 (Published 13 November 2024)Cite this as: BMJ 2024;387:q2437 After all these years, why has patient safety not improved? In late 1999, the US Institute of Medicine’s report “To Err is Human: Building a Safer Health System” galvanized the nascent patient safety movement into action with its assertion that as many ...

Current Approaches to Non-Invasive Ventilation in Critically Ill Patients In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Non-invasive ventilation is extensively employed in the management of acute hypoxaemic and hypercapnic respiratory failure, offering a potential means to circumvent intubation in carefully selected patients under vigilant supervision. Non-Invasive Ventilation Non-invasive ventilation (NIV) ...

Invited Commentary  January 15, 2025 Tranexamic Acid in General Surgery—Who Benefits the Most? Marjorie Liggett, Hasan Alam JAMA Surg. Published online January 15, 2025. doi:10.1001/jamasurg.2024.6060 Tranexamic acid (TXA) is not a new drug. First discovered by Utako Okamoto in 1962,1 it regained attention decades later after the CRASH-2 (Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma pati...

Tracheostomy Management: From Intensive Care to Community In ICU Thu, 28 Nov 2024 ICU Management & Practice, Volume 24 - Issue 5, 2024 Tracheostomies are widely performed for a variety of reasons in the ICU. This article outlines the process of transitioning from critical care to the community with proactive management by a multidisciplinary team to wean patients from the ventilator and from the tracheostomy.  Introduction Approximat...

Invited Commentary  January 15, 2025 Turning Stress Into Success—Surgery as Professional Sport Steven Yule, Jennifer Yule, Calum Arthur JAMA Surg. Published online January 15, 2025. doi:10.1001/jamasurg.2024.6041 In the latest issue of JAMA Surgery, Awtry et al1 report that elevated surgeon stress, measured by heart rate variability (HRV) within the first 5 minutes of operating, is inversely associated ...

Editorial  March 18, 2025 Sevoflurane Sedation in Acute Respiratory Distress Syndrome: Time to Put It to Sleep Balasubramanian Venkatesh, Naomi Hammond, Anthony Delaney JAMA. Published online March 18, 2025. doi:10.1001/jama.2025.3023 Acute respiratory distress syndrome (ARDS) is characterized by hypoxemic respiratory failure and inflammatory injury to the lungs, and occurs in 10% of all intensive care unit admissions. ARDS accounts for nearl...

Editor's Note  January 13, 2025 The Limited Role for Antiviral Therapy in Influenza Jonathan D. Baghdadi, Deborah Grady, Daniel J. Morgan JAMA Intern Med. Published online January 13, 2025. doi:10.1001/jamainternmed.2024.7258 Influenza is associated with substantial morbidity and mortality. Given this, antiviral therapy is commonly prescribed in an effort to prevent these outcomes. We therefore found it surprising that antivirals seem to make...