Mechanical Power in ARDS: Hand in Hand With Gattinoni ICU Management & Practice, Volume 25 - Issue 2, 2025 PRINT OPTIMISED SCREEN OPTIMISED High levels of mechanical power are associated with a higher incidence of lung damage and worse outcomes in patients with Acute Respiratory Distress Syndrome. This article explores the fundamentals of mechanical power, proper regulation of ventilatory support and the prevention of lung damage associated with mecha...

Predicting Septic Shock Mortality in ICUs with AI  In Sepsis Sun, 4 May 2025 Septic shock, a severe manifestation of sepsis, poses a persistent threat to patients in intensive care units (ICUs), with its complex pathophysiology and high mortality rates making early intervention difficult. Previous machine learning models have attempted to predict sepsis outcomes but were limited by narrow patient scopes, insufficient validation, or low generalisab...

Less is More in Shock Management In ICU Tue, 6 May 2025 Permissive hypotension, phenotyping shock, vasopressor selection and timing, and emerging interest in beta-blockade for septic patients. It is important to reconsider conventional aggressive approaches to shock management and explore the evolving concept of permissive hypotension. There is a need to avoid reflexively treating all hypotension with vasopressors or fluids and instead focus on patient-...

Enteral Nutrition in Critically Ill Patients  In ICU Tue, 6 May 2025 Enteral nutrition delivers essential nutrients to treat or prevent disease-related malnutrition in critically ill patients. This malnutrition, influenced by poor intake and inflammation, can impact the effectiveness of nutrition therapy. Evidence from recent randomised trials in both critically ill and non-critically ill patients has shaped current practices.  A recent re...

Editorials Addressing the indirect health burden of covid-19 Zhihao Lei BMJ 2025; 390 doi: https://doi.org/10.1136/bmj.r1268 (Published 02 July 2025)Cite this as: BMJ 2025;390:r1268 Consider collateral impacts when planning for future crises The covid-19 pandemic’s impact extends far beyond the direct effects of infection and death, resulting in sharp increases in other causes of illness and death that demand attention. A new time-series analysis of the Glo...

In-Hospital Mortality Using Admission CT Perfusion in Severe TBI  In ICU Tue, 6 May 2025 Traumatic brain injury (TBI) is classified into mild, moderate, and severe categories, with severe TBI (defined by a Glasgow Coma Scale ≤8) being the leading cause of hospitalisation, disability, and mortality worldwide. Globally, over 50 million people suffer from TBI annually, costing around $400 billion each year. Severe TBI is a clinical emergency that ...

Invited Commentary  Surgery Variability in Delirium After Noncardiac Surgery—Nature vs Nurture Jessica D. Spence, Emilie Belley-Côté JAMA Netw Open 2025;8;(7):e2519476. doi:10.1001/jamanetworkopen.2025.19476 In adults older than 60 years, surgery is a well-known precipitant of delirium, an acute neuropsychiatric condition characterized by an altered consciousness and fluctuating episodes of confusion and inattention.1 A recent systematic review2&n...

RECUVAP: Consensual Definition of VAP Recurrences and Various Types  In ICU Tue, 6 May 2025 Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in ICUs, linked to increased mortality, longer mechanical ventilation, and extended ICU stays. Diagnostic criteria for the first episode of VAP include clinical suspicion, chest x-ray infiltrates, and positive microbiological cultures from lower respiratory tract specimens. Ho...

Therapeutic Plasma Exchange in Patients With Acute-On-Chronic Liver Failure In ICU Mon, 28 Apr 2025 Acute-on-chronic liver failure is a serious syndrome characterised by the development of organ failure following an acute hepatic insult and is associated with high short-term mortality rates. Plasma exchange has emerged as a potential treatment option for patients with acute-on-chronic liver failure.  A recent systematic review and meta-analysis...

C-EASIE Trial: Early Administration of Vitamin C in Sepsis or Septic Shock In Sepsis Mon, 28 Apr 2025 Sepsis and septic shock represent critical conditions frequently encountered in emergency medicine, carrying significant risks of morbidity and mortality. Vitamin C has been proposed as a potential therapeutic agent due to its antioxidant, anti-inflammatory, and immunomodulatory properties.  The C-EASIE trial was conducted to evaluate whether e...