#EA25: Anaesthesia in 2050: How Emerging Technologies Will Transform Practice In ICU Sun, 25 May 2025 Each year, Euroanaesthesia opens with the prestigious Sir Robert Macintosh Lecture to honour people who have made extraordinary contributions to the fields of anaesthesiology and intensive care. In light of the rapid and transformative rise of Artificial Intelligence (AI) in healthcare, this year’s lecture explored the profound implications of emerg...

Editorial  New Pathways to Treat Staphylococcus aureus Bacteremia: Connecting the DOTS Erin K. McCreary, Preeti N. Malani JAMA Published Online: August 13, 2025 doi: 10.1001/jama.2025.13717 Staphylococcus aureus bacteremia is a leading cause of infection-related death worldwide.1 Roughly 30% of patients who develop S aureus bacteremia will die within a year of index culture, yet relatively few randomized clinical trials have evaluat...

Steroids to Battle the Perfect Storm? Role of Corticosteroid Treatment in Sepsis Complicated by ARDS In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Both sepsis and Acute Respiratory Distress Syndrome (ARDS) are major determinants of morbidity and mortality in the ICU, and sepsis is often complicated by ARDS. We discuss the role of corticosteroids in these patients. Introduction Acute respiratory distress synd...

Interpreting Elevated Lactate Levels in Shock States In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Elevated lactate levels indicate higher morbidity and mortality but require careful interpretation. In the presence of tissue hypoperfusion, they should prompt urgent haemodynamic optimisation. Without such signs, they warrant reassessing diagnosis and treatment. Serial lactate levels guide overall management but hav...

Improved SEP-1 Compliance Using AI-Supported Tools In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Artificial intelligence (AI) plays an evolving role in optimising sepsis management and SEP-1 compliance. Despite these advances, barriers persist, including alert fatigue, disparities in model performance across diverse settings, and regulatory hurdles in AI deployment. By integrating predictive models with structured...

Comment Tackling the burden of β-lactam allergy labels Philip H Li, Kimberly G Blumenthal Lancet Infect Dis 2025; 25: 834-835 Physicians frequently encounter patients who report suspected drug allergies. Many physicians adopt a cautious approach by labelling these unverified drug allergies in their medical records, which often results in patients avoiding the drugs indefinitely. However, it has been recognised that unverified β-lactam allergy labels (BALs), es...

Molecular Subphenotypes in Sepsis and Acute Respiratory Distress Syndrome In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Sepsis and Acute Respiratory Distress Syndrome (ARDS) are heterogeneous critical illness syndromes. Molecular subphenotyping shows promise in furthering our understanding of these syndromes and may offer a more precise method for identifying appropriate therapies.  Current Definitions of ...

Advancing Cardiovascular Management in Critical Care: A Focus on Vasopressors and Beta-Blockers In ICU Tue, 20 May 2025 Clinical insights on the use of beta-blockers and vasopressors in the ICU, focusing on landiolol and vasopressin. When managing cardiovascular instability in critically ill patients, intensivists often face a delicate balancing act: controlling heart rate without compromising haemodynamics and maintaining perfusion without excessive va...

Invited Commentary  AI in Surgery Intelligent, Human-Centric Delivery Is Needed to Maximize AI Carla M. Pugh, Mitra Ann Alikhani, Adam Rodman JAMA Surg Published Online: August 6, 2025 doi: 10.1001/jamasurg.2025.2550 Artificial intelligence (AI)–augmented learning is here, and many believe it is superior to all past endeavors. AI’s ability to deliver real-time, objective, standardized feedback is an unprecedented game changer. Giglio et al1 inv...

Searching for the Single Best Sedative In ICU Thu, 22 May 2025 Critically ill patients on invasive mechanical ventilation often need continuous sedation to manage pain and anxiety. For decades, researchers have sought the ideal sedative for these patients.  Propofol, a lipid-based drug that enhances γ-aminobutyric acid (GABA) receptor activity, is widely used in intensive care for varying levels of sedation. Dexmedetomidine is another sedative ...