EDITORIAL A Less Invasive Approach to Intensive Care Hayley B. Gershengorn N Engl J Med Published October 29, 2025 DOI: 10.1056/NEJMe2512006 The intensive care unit (ICU) conjures images of unconscious patients surrounded by machines and penetrated by devices — endotracheal tubes, surgical drains, and urinary, venous, and arterial catheters. Although this scenario may be necessary for some patients, for many, high-quality studies have shown benefits of a di...

EDITORIAL Glucocorticoids for Pneumonia in Africa — Old Therapy, New Context Arthur Kwizera, Martin W. Dünser Published October 29, 2025 DOI: 10.1056/NEJMe2514533 The African continent is home to 1.55 billion people, one fifth of the world’s population, spread over an area larger than the United States, China, and India combined. The disease burden is enormous,1 and health care resources are severely constrained. In one multinational survey, one i...

Machine Learning vs Humans: Identifying Trauma Patients in Need of Haemorrhage Control Resuscitation In ICU Mon, 16 Jun 2025 Timely identification of haemorrhage control resuscitation (HCR) needs in trauma patients is challenging due to inconsistent recognition and decision-making, which delay treatment and harm outcomes. Traditional clinical tools like scores and flowcharts are easy to use but often lack predictive accuracy and are poorly integrated i...

Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation In ICU Mon, 16 Jun 2025 Prolonged mechanical ventilation (MV) increases the risk of death, disability, and healthcare costs. Over one-third of patients entering the weaning phase experience difficulty, often due to diaphragm dysfunction. Traditional inspiratory muscle training has shown limited success.  Transvenous diaphragm neurostimulation, a novel method involvin...

Conservative Oxygen Therapy in Mechanically Ventilated Patients In ICU Mon, 16 Jun 2025 Oxygen therapy is a common treatment in ICUs, traditionally given liberally to avoid hypoxaemia and its complications. However, excessive oxygen can also be harmful, making it important to balance oxygen levels. While many clinical trials have shown no significant difference in outcomes between conservative and liberal oxygen strategies in critically ill patients...

Nursing Care Considerations of Sepsis-Induced ARDS  In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 This article highlights sepsis early recognition and prevention to reduce the risk of developing sepsis-induced ARDS while emphasising pathophysiology, early recognition, and early intervention for both conditions. Introduction Sepsis, a life-threatening condition caused by a dysregulated immune response to...

Anti-Inflammatory Strategies for Sepsis-Induced Lung Injury In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Sepsis-induced ARDS is a critical condition that may require anti-inflammatory strategies. There are some promising treatments that may alter the evolution, including corticosteroids, vitamin C, NET inhibitors, and statins, which help mitigate excessive immune response and improve clinical outcomes. Introdu...

JOURNAL ARTICLE A Clear and Present Danger: Encephalitis Due to Infection With Normocellular Cerebrospinal Fluid Karen Bloch,  Carol Glaser Clinical Infectious Diseases, Volume 81, Issue 1, 15 July 2025, Pages 188–189, https://doi.org/10.1093/cid/ciae387 Can encephalitis due to an infectious cause be present despite normocellular cerebral spinal fluid (CSF)? In the article “Absence of cerebrospinal fluid pleocytosis in encephalitis” by Habis et al, more than a...

Statins Improve Clinical Outcomes in Patients With Sepsis In Sepsis Wed, 11 Jun 2025 Sepsis is a life-threatening condition that affects approximately 750,000 people annually in the U.S., with a mortality rate of around 27%. In about 15% of these cases, sepsis progresses to septic shock, a more severe state marked by dangerously low blood pressure and reduced tissue perfusion, where the risk of death increases to 30-40%. Prompt treatment significant...

Trauma Triage Model for Critical Care Transport In ICU Wed, 11 Jun 2025 Advancements in civilian casualty care can reduce mortality from trauma, particularly those due to airway compromise or prehospital haemorrhage. Timely delivery of lifesaving interventions (LSIs) is crucial but challenging for prehospital medics, who must make rapid decisions under constrained conditions with limited experience and unreliable triage guidelines. Machine learning ...