Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic Hallie C. Prescott, ToddW. Rice JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.16747 Corticosteroids, such as hydrocortisone and dexamethasone, have anti-inflammatory, antifibrotic, and vasoconstrictive effects, which intensivists have been trying to leverage for decades to improve outcomes in patients with acute respiratory distress syndrome (ARDS) and septic shock. In the f...

COMMENT|ONLINE FIRST ECMO for severe ARDS associated with COVID-19: now we know we can, but should we? Kiran Shekar, Arthur S Slutsky, Daniel Brodie JAMA Published:August 13, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30357-X The initial months of the COVID-19 pandemic were dominated by studies reporting poor and varied outcomes in patients who developed severe acute respiratory distress syndrome (ARDS) associated with the disease. Variable mortality could...

ICU Management & Practice, Volume 20 - Issue 2, 2020 Making Decisions During ICU Night Shifts: Challenges and Considerations We review the decision-making processes during night shifts focusing on the perspective of residents and fellows. We explore nighttime decisions about extubations, ICU discharge, withholding/withdrawing and night shift cross-coverage. Taking a night shift in the ICU can be challenging, particularly from a resident/fellow perspectiv...

COVID-19: Molecular Mechanisms of Gender Differences The COVID-19 pandemic has resulted in hundreds of thousands of deaths around the globe. An important thing to note is that more men have died from COVID-19 than women. A European study shows that men had a slightly higher incidence of COVID-19 with no respiratory distress compared to women. Still, more males with COVID-19 developed severe respiratory failure compared to females. Other studies also show that men are m...

翻译：陈燕 Comment & Response August 3, 2020 The Uncertain Role of Corticosteroids in the Treatment of COVID-19—Reply Yuanlin Song, Chaomin Wu, Xiaoyan Chen JAMA Intern Med. Published online August 3, 2020. doi:10.1001/jamainternmed.2020.2435 In Reply In response to the concerns about survival bias and the findings regarding methylprednisolone in our Original Investigation,1 we treated methylprednis...

翻译：陈燕 Comment & Response August 3, 2020 The Uncertain Role of Corticosteroids in the Treatment of COVID-19 Theodore G. Liou, Frederick R. Adler, Nathan D. Hatton JAMA Intern Med. Published online August 3, 2020. doi:10.1001/jamainternmed.2020.2438 To the Editor Infection with coronavirus disease 2019 (COVID-19) causes exuberant lung inflammation leading to respiratory failure, acute respiratory dist...

The Landscape of COVID-19 Clinical Trials Introduction In an effort to gather evidence through scientifically rigorous trials to guide optimal management of COVID-19, researchers in the US have started multiple parallel clinical trials. In this systematic review, the researchers evaluate the characteristics and issues surrounding simultaneous trials being conducted.   Methods This systematic review, conducted in June 2020, used publicly ava...

COVID-19: Neurological Associations The most common manifestation of COVID-19 has been respiratory illness with a growing recognition of neurological sequelae. In this recent review, researchers take into consideration the neurological features of COVID-19 and summarise the evidence available to suggest an investigation framework to guide future studies.  Before COVID-19, there were six other coronaviruses known to infect humans and cause respiratory pathology....

What is the Relevance of Cytokine Storm to COVID-19? COVID-19, in its most severe form, leads to life-threatening pneumonia and acute respiratory distress syndrome (ARDS). In patients with this severity of the coronavirus, mortality rate can approach 40 to 50%.  The mechanism of COVID-19 induced lung injury is still vague, but the term cytokine storm is being used quite frequently in scientific publications as well as the media. What is this cytokine storm and ...

COVID-19 and Acute Kidney Injury Incidence and risk factors for acute kidney injury (AKI) in COVID-19 patients Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5449 hospitalized COVID-19 patients, AKI was observed primarily in patients with respiratory failure, with AKI developing in 89.7% of patients on mechanical ventilation compared ...