Original Investigation  May 19, 2024 Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial Graham Devereux, Seonaidh Cotton, Mintu Nath, et al JAMA. 2024;332(6):462-470. doi:10.1001/jama.2024.8771 Key Points Question  For people with chronic obstructive pulmonary disease (COPD) at high risk of exacerbations, does bisoprolol reduc...

Barriers to Female Leadership in Intensive Care Medicine In ICU Mon, 26 Aug 2024 The field of intensive care medicine faces a significant gender imbalance in leadership positions, with women underrepresented due to various factors, including gender bias, societal messages, and a confidence gap that leads to self-censorship. Many qualified women face obstacles like outdated leadership models and systemic biases, which hinder their advancement. To add...

Original Investigation  Public Health June 13, 2024 Hand Hygiene Education Components Among First-Year Nursing Students: A Cluster Randomized Clinical Trial Jing Chen, Lin Yang, Yim-Wah Mak, et al JAMA Netw Open. 2024;7(6):e2413835. doi:10.1001/jamanetworkopen.2024.13835 Key Points Question  Which components of an educational program featuring a handwashing instructional video and hand sca...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original The use of echocardiography in the management of shock in critical care: a prospective, multi-centre, observational study Flower L. et al “It’s all about setting the stage.” The nurse facilitator trial: perceived outcomes and implementation issues. A qualitative study among ICU clinicians and nurse facilitators Renet A .et al Long-term effects of flexible visitation in the intensive care unit on fami...

Fluid responsiveness in acute respiratory distress syndrome patients: a post hoc analysis of the HEMOPRED study Joseph, A., Evrard, B., Petit, M. et al. Intensive Care Med(2024). https://doi.org/10.1007/s00134-024-07639-6 Abstract Purpose Optimal fluid management in patients with acute respiratory distress syndrome (ARDS) is challenging due to risks associated with both circulatory failure and fluid overload. The performance of dynamic indices to predict fl...

High vs Standard Protein Provision and Functional Recovery - PRECISe In ICU Mon, 26 Aug 2024 Rapid skeletal muscle wasting during critical illness negatively affects both short- and long-term outcomes after ICU admission. Increasing dietary protein intake may help reduce muscle wasting and improve post-ICU function. ICU-acquired weakness (ICU-AW) is common among ICU survivors and negatively impacts both short- and long-term outcomes. It results from...

Epidemiology of acute hypoxaemic respiratory failure in Australian and New Zealand intensive care units during 2005–2022. A binational, registry-based study Ling, R.R., Ponnapa Reddy, M., Subramaniam, A. et al. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07609-y Abstract Purpose Acute hypoxaemic respiratory failure (AHRF) is a common reason for intensive care unit (ICU) admission. However, patient characteristics, outcomes, and trends over...

Landiolol for heart rate control in patients with septic shock and persistent tachycardia. A multicenter randomized clinical trial (Landi-SEP) Rehberg, S., Frank, S., Černý, V. et al. Intensive Care Med 50, 1622–1634 (2024) https://doi.org/10.1007/s00134-024-07587-1 Abstract Purpose Excessive tachycardia in resuscitated septic shock patients can impair hemodynamics and worsen patient outcome. We investigated whether heart rate (HR) control can be achieve...

Impact of Flexible Visitation in the ICU on Family Members In ICU Mon, 26 Aug 2024 Despite ongoing restrictive family visitation policies in ICUs worldwide, contemporary guidelines advocate for more flexible visitation. Flexible policies aim to enhance the ICU experience for both patients and their families and are linked to reduced acute anxiety in both groups and decreased depression in family members. These flexible policies do not increase the risk...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES "ICU TOOLBOX" TOPICAL COLLECTION EditorialClinical governance in intensive care medicineCarenzo L., Constantini E. and Cecconi M. When should I start broad-spectrum antibiotics?Timsit J-F., Depuydt P. and Kanj S. S. Diagnostic tests for infections in critically ill immunocompromised patientsDumas G., Joseph A. and Zafrani L. Understanding the DiseaseUnderstanding buffering of metabolic acidosis in critical illne...