Original Investigation  Caring for the Critically Ill Patient December 9, 2024 Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial Paul Dark, Anower Hossain, Daniel F. McAuley, et al JAMA. Published online December 9, 2024. doi:10.1001/jama.2024.26458 Key Points Question  Do critically ill adult patients hospitalized for suspected sepsis and treated w...

Long-COVID, Post-Sepsis-Syndrome, Post-Intensive-Care-Syndrome - How Are They Related? In Sepsis Mon, 2 Sep 2024 A recent review addresses the challenge of categorising new persistent symptoms that patients experience after recovering from ICU-treated sepsis caused by COVID-19. It explores whether these symptoms fit into one of the following categories: Long-COVID, Post-Sepsis Syndrome, or Post-Intensive-Care Syndrome. It also considers if patients mig...

Aztreonam–avibactam versus meropenem for the treatment of serious infections caused by Gram-negative bacteria (REVISIT): a descriptive, multinational, open-label, phase 3, randomised trial Yehuda Carmeli, José Miguel Cisneros, Mical Paul, et al. Lancet Infect Dis 2024 Available online 7 October 2024 https://doi.org/10.1016/S1473-3099(24)00499-7 Summary Background There is a need for additional therapeutic options for serious infections caused by Gram-neg...

Global Burden of Bacterial Antimicrobial Resistance In ICU Thu, 3 Oct 2024 In 2014, the Review on Antimicrobial Resistance (AMR) predicted that AMR could lead to 10 million deaths by 2050, prompting global attention and commitments from the World Health Organization (WHO) and the United Nations (UN). Despite these efforts, national action plans to combat AMR have seen uneven implementation and funding, leading to uncertain progress.  A global e...

Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target trial emulation Ahmed Babiker, Sarah Warner, Xiaobai Li, et al. Lancet Infect Dis 2024 Available online 10 October 2024 https://doi.org/10.1016/S1473-3099(24)00507-3 Summary Background Adjunctive clindamycin use...

Conservative vs Liberal Oxygen Targets in VA-ECMO In ICU Mon, 2 Sep 2024 Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used for treating cardiogenic shock and refractory cardiac arrest but involves significant risks and resource demands. It improves blood flow and oxygen content but often results in arterial hyperoxaemia. Although hyperoxaemia can be managed by adjusting the ECMO circuit and ventilator, the optimal oxygenat...

Mechanisms and causes of death after abdominal surgery in low-income and middle-income countries: a secondary analysis of the FALCON trial NIHR Global Health Research Unit on Global Surgery Lancet Global Health 2024 online first September 05, 2024 https://doi.org/10.1016/S2214-109X(24)00318-8 Summary Background Death after surgery is devasting for patients, families, and communities, but remains common in low-income and middle-income countries (LMICs). W...

Awake prone positioning for COVID-19 patients with acute respiratory failure: unknown appropriate duration Zeng, G., Wang, L  Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07637-8 In a recent issue of Intensive Care Medicine, we read with great interest the article by Liu et al. [1] who conducted a trial to explore whether prolonged awake prone positioning (APP) would reduce the rate of intubation at 28 days when compared with a shorter perio...

Microbiology testing capacity and antimicrobial drug resistance in surgical-site infections: a post-hoc, prospective, secondary analysis of the FALCON randomised trial in seven low-income and middle-income countries NIHR Global Health Research Unit on Global Surgery Lancet Global Health 2024 epub ahead of print https://doi.org/10.1016/S2214-109X(24)00330-9 Summary Background Surgical-site infection (SSI) is one of the most common health-care-associated i...

Global estimation of dietary micronutrient inadequacies: a modelling analysis Simone Passarelli, Christopher M Free, Alon Shepon, et al Lancet Global Health 2024; 12: e1590-e1599 Summary Background Inadequate micronutrient intakes and related deficiencies are a major challenge to global public health. Analyses over the past 10 years have assessed global micronutrient deficiencies and inadequate nutrient supplies, but there have been no global estimates of i...