Editorial  December 10, 2024 Is High-Flow Oxygen the Standard for All Patients With Acute Respiratory Failure? Jean-Pierre Frat, Sylvain Le Pape, Arnaud W. Thille JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25906 Hypoxemic acute respiratory failure denotes oxygenation failure attributable to various mechanisms, including ventilation-perfusion mismatch, increased shunt, diffusion impairment, and alveolar hypoventilation. Th...

eHealth Interventions to Treat Post-Intensive Care Syndrome In ICU Thu, 3 Oct 2024 Post Intensive Care Syndrome (PICS) is a critical issue affecting survivors of intensive care. PICS involves new or worsened physical, psychological, and cognitive impairments after critical illness, significantly impacting health-related quality of life (HRQoL), functional outcomes, and employment.  Critical care rehabilitation occurs in four phases: acute recov...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial RENOVATE Investigators and the BRICNet Authors JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.26244 Key Points Question  Is high-flow nasal oxygen noninferior to noninvasive ventilation for rate of en...

Physiologic Effects of ECMO in Patients With Severe ARDS In ICU Mon, 9 Sep 2024 In patients with severe acute respiratory distress syndrome (ARDS), managing gas exchange and avoiding ventilation-induced lung injury (VILI) are key challenges. Venovenous extracorporeal membrane oxygenation (ECMO) is used for severe ARDS with persistent hypoxaemia, effectively improving gas exchange and reducing ventilation pressures, though it doesn't support the cardiov...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial Tobias Arleth, Josefine Baekgaard, Volkert Siersma, et al JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25786 Key Points Question  Does an early, 8-hour restrictive oxygen strategy compared with a liberal oxygen strategy in severely inj...

ESICM Webinar – Cardiovascular Management After Surgery In ICU Tue, 1 Oct 2024 In a webinar at the ESICM Congress, Dr Aretha and Dr Garcia-Alvarez spoke about cardiovascular management after surgery. More specifically, Dr Aretha spoke about the management of post-operative atrial fibrillation, and Dr Garcia-Alvarez spoke about the importance of early application of vasopressin in septic shock patients. Management of Postoperative Atrial Fibrillation Aft...

ARTICLESVolume 12, Issue 10P787-798October 2024 Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months Charles S Haworth, Michal Shteinberg, Kevin Winthrop, et al Lancet Respir Med 2024; 12: 787-798 Summary Background Chronic lung infection with Pseudomo...

Human-Centred AI Tool for Sepsis Management In Sepsis Thu, 29 Aug 2024 A new artificial intelligence tool, SepsisLab, has been developed to assist clinicians in making decisions about hospital patients at risk for sepsis, with a distinctive feature: it acknowledges its uncertainty. It indicates which demographic data, vital signs, and lab test results are needed to enhance its predictive accuracy. The research was published in KDD '24: Proceedings of t...

ORIGINAL ARTICLE Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage Shane W. English, Anthony Delaney, Dean A. Fergusson, et al N Engl J Med Published December 9, 2024 DOI: 10.1056/NEJMoa2410962 Abstract BACKGROUND The effect of a liberal red-cell transfusion strategy as compared with a restrictive strategy in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear. METHODS W...

Fever Prevention in Patients With Acute Vascular Brain Injury In ICU Thu, 3 Oct 2024 Stroke is a leading cause of death and disability. Fever occurs in up to 90% of stroke patients within the first seven days and is linked to secondary brain injury and worse outcomes. For every 1°C increase in temperature, the odds of poor outcomes and short-term mortality increase by 2.2, particularly within the first 24 hours. Fever has a similarly negative impact on...